Ushiyama, Fumihito et al. published their research in Bioorganic & Medicinal Chemistry in 2020 | CAS: 144222-22-0

1-Boc-4-(Aminomethyl)piperidine (cas: 144222-22-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Quality Control of 1-Boc-4-(Aminomethyl)piperidine

Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors was written by Ushiyama, Fumihito;Amada, Hideaki;Mihara, Yasuhiro;Takeuchi, Tomoki;Tanaka-Yamamoto, Nozomi;Mima, Masashi;Kamitani, Masafumi;Wada, Reiko;Tamura, Yunoshin;Endo, Mayumi;Masuko, Aiko;Takata, Iichiro;Hitaka, Kosuke;Sugiyama, Hiroyuki;Ohtake, Norikazu. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Quality Control of 1-Boc-4-(Aminomethyl)piperidine This article mentions the following:

The global increase in multidrug-resistant pathogens has caused severe problems in the treatment of infections. To overcome these difficulties, the advent of a new chem. class of antibacterial drug is eagerly desired. We aimed at creating novel antibacterial agents against bacterial type II topoisomerases, which are well-validated targets. TP0480066 (compound 32) has been identified by using structure-based optimization originated from lead compound 1, which was obtained as a result of our previous lead identification studies. The MIC90 values of TP0480066 against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE), and genotype penicillin-resistant Streptococcus pneumoniae (gPRSP) were 0.25, 0.015, and 0.06 渭g/mL, resp. Hence, TP0480066 can be regarded as a promising antibacterial drug candidate of this chem. class. In the experiment, the researchers used many compounds, for example, 1-Boc-4-(Aminomethyl)piperidine (cas: 144222-22-0Quality Control of 1-Boc-4-(Aminomethyl)piperidine).

1-Boc-4-(Aminomethyl)piperidine (cas: 144222-22-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Quality Control of 1-Boc-4-(Aminomethyl)piperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem