Exploring the utility of co-amorphous materials to concurrently improve the solubility and permeability of Fexofenadine was written by Uppala, Sravya;Vullendula, Sai Krishna Anand;Yarlagadda, Dani Lakshman;Dengale, Swapnil Jayant. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Formula: C32H39NO4 The following contents are mentioned in the article:
In this study, the co-amorphous materials of BCS class-IV drug Fexofenadine were prepared by employing Naringin as a co-former. Naringin was employed as a coformer anticipating the concurrent improvement in the solubility and permeability by virtue of its good glass-forming ability and p-gp inhibition potential, resp. The solid-state characterization of prepared co-amorphous materials by powder-XRD, DSC, and FTIR revealed amorphous state and 蟺-蟺 interactions between Fexofenadine and Naringin. The interactions were confirmed by Mol. Dynamic studies employing Schrodinger material science Suite. The co-amorphous materials demonstrated improved solubility and dissolution for both Fexofenadine and Naringin. The deliquescent nature of Naringin led to the significant moisture uptake by coamorphous materials. However, the dissolution advantage of Fexofenadine and Naringin sustained in the stability samples due to accelerated 蟺-蟺 interactions in the presence of water. The permeability of co-amorphous samples was estimated using everted gut sac method which was found improved by 5-fold and 3.5-fold for Fexofenadine and Naringin, resp. The improvement in the permeability was attributed to the interplay between solubility improvement and dose-dependent P-gp inhibition by Naringin. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Formula: C32H39NO4).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Formula: C32H39NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem