Effects of different pediatric drugs on the color stability of various restorative materials applicable in pediatric dentistry was written by Tuzuner, Tamer;Turgut, Sedanur;Baygin, Ozgul;Yilmaz, Nagehan;Tuna, Elif Bahar;Ozen, Bugra. And the article was included in BioMed Research International in 2017.Formula: C21H29Cl3N2O2 This article mentions the following:
The chronic recommendation of pediatric drugs could exhibit erosive and cariogenic problems. To evaluate the effects of different pediatric drugs on the color stability of various restorative materials. Five specimens (1 mm × 3 mm) were prepared and immersed in ten different pediatric drugs and agitated every 8 h daily for 2 min up to 1 wk. Between immersion periods, the samples were stored in artificial saliva. After 1-wk period, ΔE* values were calculated Two-way ANOVA and Fisher’s LSD test were used for statistical anal. at a level of p < 0.05. Results. ΔE* values were only significantly influenced by restorative material factor (p < 0.001) and varied in the range of 2.08 and 6.55 units for all drugs/restorative materials. The highest ΔE* was found in Ferrosanol B-composite (6.55 ± 1.38) and the lowest one was found in Dolven-glass ionomer (2.08 ± 0.40) pairwise. The most prominent ΔE* value elevations were obtained in composite material compared to the compomer and/or glass ionomers in Macrol, Ferrosanol B, and Ventolin (p < 0.001; for all) and also for other drugs (p < 0.05). Dolven exhibited significantly higher values compared to Augmentin (p = 0.021), Macrol (p = 0.018), and Ventolin (p = 0.013) in compomer group. The clin. perceptible color changes for tested composite/pediatric drug pairwise can be more problematic than compomer and glass ionomers in pediatric dentistry. In the experiment, the researchers used many compounds, for example, 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3Formula: C21H29Cl3N2O2).
2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Formula: C21H29Cl3N2O2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics