Synthetic Route of C7H11NO4On March 15, 2005, Turner, Jennifer J.; Gerrard, Juliet A.; Hutton, Craig A. published an article in Bioorganic & Medicinal Chemistry. The article was 《Heterocyclic inhibitors of dihydrodipicolinate synthase are not competitive》. The article mentions the following:
A series of piperidine- and pyridine-2,6-dicarboxylate derivatives has been evaluated as potential inhibitors of dihydrodipicolinate synthase (DHDPS). The compounds were designed with oxygen functionality at the C-4 position in order to mimic the putative enzyme product HTHDP. Most compounds displayed weak-moderate inhibition of DHDPS. Addnl., the most potent inhibitors were shown not to be competitive, indicating they do not bind at the active site. Discrepancies between the two common assay systems-the imidazole assay and the coupled assay-were observed which are attributed to inherent problems in the imidazole assay, leading to artifactually low Ki measurements. In the experiment, the researchers used Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1Synthetic Route of C7H11NO4)
Cis-piperidine-2,6-dicarboxylic acid(cas: 59234-40-1) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Synthetic Route of C7H11NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem