Studies on the structure-activity relationship of the basic amine of phenylpiperazines as melanocortin-4 receptor antagonists was written by Tran, Joe A.;Arellano, Melissa;Fleck, Beth A.;Pontillo, Joseph;Marinkovic, Dragan;Tucci, Fabio C.;Wen, Jenny;Saunders, John;Chen, Chen. And the article was included in Medicinal Chemistry in 2008.HPLC of Formula: 25560-00-3 This article mentions the following:
A series of piperazinephenethylamines were synthesized to study the contribution of a basic amine to binding affinity at the melanocortin-4 receptor. Several potent compounds from this series possessed subnanomolar Ki values in a competition binding assay. In the experiment, the researchers used many compounds, for example, 3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3HPLC of Formula: 25560-00-3).
3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.HPLC of Formula: 25560-00-3
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem