A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Safety of Methyl 1-benzyl-4-oxopiperidine-3-carboxylate, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 57611-47-9, Name is Methyl 1-benzyl-4-oxopiperidine-3-carboxylate, molecular formula is C14H17NO3. In a Article, authors is Ali, Fadia E.£¬once mentioned of 57611-47-9
Orally Active and Potent Inhibitors of gamma-Aminobutyric Acid Uptake
3-Pyrrolidineacetic acid (1a), certain piperidinecarboxylic acids – i.e., piperidinecarboxylic acid (2a), 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid (3a), and cis-4-hydroxy-3-piperidinecarboxylic acid (4a) – cis-3-aminocyclohexanecarboxylic acid (5a, cis-3-ACHC), and gamma-aminobutyric acid (6a, GABA) itself are among the most potent inhibitors of <3H>GABA uptake by neurons and glia in vitro.These hydrophilic amino acids, however, do not readily enter the central nervous system in pharmacologically significant amounts following peripheral administration.We now report that N-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylic acid (2b) is a specific GABA-uptake inhibitor that is more potent, more lipophilic and, in limited testing, as selective as 2a.Similar results were obtained with the N-(4,4-diphenyl-3-butenyl) derivatives of 1a, 3a, and 4a.By contrast, N-(4,4-diphenyl-3-butenyl) derivatives of 5a and 6a were not more potent than the parent amino acids and appear to inhibit GABA uptake, at least in part, by a nonselective mechanism of action.The N-(4,4-diphenyl-3-butenyl)amino acids 1b-4b exhibit anticonvulsant activity in rodents following oral or intraperitoneal administration
Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Safety of Methyl 1-benzyl-4-oxopiperidine-3-carboxylate
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H20496N – PubChem