Related Products of 77542-18-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.77542-18-8, Name is 1-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide, molecular formula is C8H16INO. In a Article，once mentioned of 77542-18-8
Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy. We previously described a new approach for the design of CCR2 antagonists by the use of structure’kinetics relationships (SKRs). Herein we report new findings on the structure’affinity relationships (SARs) and SKRs of the reference compound MK- 0483, its diastereomers, and its structural analogues as CCR2 antagonists. The SARs of the 4-arylpiperidine group suggest that lipophilic hydrogen-bond-accepting substituents at the 3- position are favorable. However, the SKRs suggest that a lipophilic group with a certain size is desired [e.g., 3-Br: Ki= 2.8 nm, residence time (tres)=243 min; 3-iPr: Ki=3.6 nm, tres= 266 min]. Alternatively, additional substituents and further optimization of the molecule, while keeping a carboxylic acid at the 3-position, can also prolong tres; this was most prominently observed in MK-0483 (Ki=1.2 nm, tres=724 min) and a close analogue (Ki=7.8 nm) with a short residence time.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 77542-18-8
Reference：
Piperidine – Wikipedia,
Piperidine | C5H21740N – PubChem