Electric Literature of 871727-05-8, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 871727-05-8, Name is 6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid, molecular formula is C13H21NO4. In a Article£¬once mentioned of 871727-05-8
Structural Optimizations of Thieno[3,2-b]pyrrole Derivatives for the Development of Metabolically Stable Inhibitors of Chikungunya Virus
Chikungunya virus (CHIKV) is a re-emerging vector-borne alphavirus, and there is no approved effective antiviral treatment currently available for CHIKV. We previously reported the discovery of thieno[3,2-b]pyrrole 1b that displayed good antiviral activity against CHIKV infection in vitro. However, it has a short half-life in the presence of human liver microsomes (HLMs) (T1/2 = 2.91 min). Herein, we report further optimization studies in which potential metabolically labile sites on compound 1b were removed or modified, resulting in the identification of thieno[3,2-b]pyrrole 20 and pyrrolo[2,3-d]thiazole 23c possessing up to 17-fold increase in metabolic half-lives in HLMs and good in vivo pharmacokinetic properties. Compound 20 not only attenuated viral RNA production and displayed broad-spectrum antiviral activity against other alphaviruses and CHIKV isolates but also exhibited limited cytotoxic liability (CC50 > 100 muM). These studies have identified two compounds that have the potential for further development as antiviral drugs against CHIKV infection.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Electric Literature of 871727-05-8, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 871727-05-8, in my other articles.
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Piperidine – Wikipedia,
Piperidine | C5H20948N – PubChem