Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Computed Properties of C5H9NO, Which mentioned a new discovery about 50717-82-3
The introduction of a trifluoromethyl (CF3) group can dramatically improve a compound?s biological properties. Despite the well-established importance of trifluoromethylated compounds, general methods for the trifluoromethylation of alkyl C?H bonds remain elusive. Here we report the development of a dual-catalytic C(sp3)?H trifluoromethylation through the merger of light-driven, decatungstate-catalysed hydrogen atom transfer and copper catalysis. This metallaphotoredox methodology enables the direct conversion of both strong aliphatic and benzylic C?H bonds into the corresponding C(sp3)?CF3 products in a single step using a bench-stable, commercially available trifluoromethylation reagent. The reaction requires only a single equivalent of substrate and proceeds with excellent selectivity for positions distal to unprotected amines. To demonstrate the utility of this new methodology for late-stage functionalization, we have directly derivatized a broad range of approved drugs and natural products to generate valuable trifluoromethylated analogues. Preliminary mechanistic experiments reveal that a ?Cu?CF3? species is formed during this process and the critical C(sp3)?CF3 bond-forming step involves the copper catalyst. [Figure not available: see fulltext.].
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Computed Properties of C5H9NO, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 50717-82-3
Reference：
Piperidine – Wikipedia,
Piperidine | C5H18N – PubChem