Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Hayashi, Yujiro, once mentioned the application of 3040-44-6, Name is 1-(2-Hydroxyethyl)piperidine, molecular formula is C7H15NO, molecular weight is 129.2001, MDL number is MFCD00006512, category is piperidines. Now introduce a scientific discovery about this category, Application In Synthesis of 1-(2-Hydroxyethyl)piperidine.
Asymmetric Michael Reaction of Aldehydes and alpha-Cyano alpha,beta-Unsaturated Esters Catalyzed by Diphenylprolinol Silyl Ether; a Facile Asymmetric Route to 3,4,5-Trisubstituted Piperidines
A highly enantioselective diphenylprolinol silyl ether-mediated asymmetric Michael reaction of a variety of aldehydes and beta-substituted alpha-cyano alpha,beta-unsaturated esters was developed. The organocatalytic conjugate addition provided synthetically useful chiral adducts possessing three consecutive stereocenters and suitably oriented functional handles that were readily transformed via a sequence of reductive-cyclization and subsequent epimerization to furnish single isomers of 3,4,5-trisubstituted piperidines with high levels of yield and excellent enantiopurity.
If you are interested in 3040-44-6, you can contact me at any time and look forward to more communication. Application In Synthesis of 1-(2-Hydroxyethyl)piperidine.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem