Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products, Recommanded Product: (R)-1-Boc-3-Aminopiperidine, 188111-79-7, Name is (R)-1-Boc-3-Aminopiperidine, molecular formula is C10H20N2O2, belongs to piperidines compound. In a document, author is Neelamkavil, Santhosh F., introduce the new discover.
Discovery of MK-8282 as a Potent G-Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes
The ever-growing prevalence of type 2 diabetes in the world has necessitated an urgent need for multiple orally effective agents that can regulate glucose homeostasis with a concurrent reduction in body weight. G-Protein coupled receptor 119 (GPR119) is a GPCR target at which agonists have demonstrated glucose-dependent insulin secretion and shows beneficial effects on glycemic control. Herein, we describe our efforts leading to the identification of a potent, oral GPR-119 agonist, MK-8282, which shows improved glucose tolerance in multiple animal models and has excellent off-target profile. The key design elements in the compounds involved a combination of a fluoro-pyrimidine and a conformationally constrained bridged piperidine to impart good potency and efficacy.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 188111-79-7. Recommanded Product: (R)-1-Boc-3-Aminopiperidine.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem