I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy very interesting. Saw the article Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia published in 2019. SDS of cas: 177-11-7, Reprint Addresses Fossey, JS (corresponding author), Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England.; Agathanggelou, A (corresponding author), Univ Birmingham, Inst Canc & Genom Sci, Birmingham B15 2TT, W Midlands, England.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane
Parthenolide is a natural product that exhibits anti-leukaemic activity, however, its clinical use is limited by its poor bioavailability. It may be extracted from feverfew and protocols for growing, extracting and derivatising it are reported. A novel parthenolide derivative with good bioavailability and pharmacological properties was identified through a screening cascade based on in vitro anti-leukaemic activity and calculated drug-likeness properties, in vitro and in vivo pharmacokinetics studies and hERG liability testing. In vitro studies showed the most promising derivative to have comparable anti-leukaemic activity to DMAPT, a previously described parthenolide derivative. The newly identified compound was shown to have pro-oxidant activity and in silico molecular docking studies indicate a prodrug mode of action. A synthesis scheme is presented for the production of amine 7 used in the generation of 5f.
SDS of cas: 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Li, XJ; Payne, DT; Ampolu, B; Bland, N; Brown, JT; Dutton, MJ; Fitton, CA; Gulliver, A; Hale, L; Hamza, D; Jones, G; Lane, R; Leach, AG; Male, L; Merisor, EG; Morton, MJ; Quy, AS; Roberts, R; Scarll, R; Schulz-Utermoehl, T; Stankovic, T; Stevenson, B; Fossey, JS; Agathanggelou, A or send Email.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem