Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 106-52-5, Name is 1-Methylpiperidin-4-ol, SMILES is OC1CCN(C)CC1, belongs to piperidines compound. In a document, author is Lazewska, Dorota, introduce the new discover, Recommanded Product: 1-Methylpiperidin-4-ol.
Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H-3 Receptor Antagonists and Monoamine Oxidase B Inhibitors
Dual target ligands are a promising concept for the treatment of Parkinson’s disease (PD). A combination of monoamine oxidase B (MAO B) inhibition with histamine H-3 receptor (H3R) antagonism could have positive effects on dopamine regulation. Thus, a series of twenty-seven 4-tert-butylphenoxyalkoxyamines were designed as potential dual-target ligands for PD based on the structure of 1-(3-(4-tert-butylphenoxy)propyl)piperidine (DL76). Probed modifications included the introduction of different cyclic amines and elongation of the alkyl chain. Synthesized compounds were investigated for human H3R (hH(3)R) affinity and human MAO B (hMAO B) inhibitory activity. Most compounds showed good hH(3)R affinities with K-i values below 400 nM, and some of them showed potent inhibitory activity for hMAO B with IC50 values below 50 nM. However, the most balanced activity against both biological targets showed DL76 (hH(3)R: K-i = 38 nM and hMAO B: IC50 = 48 nM). Thus, DL76 was chosen for further studies, revealing the nontoxic nature of DL76 in HEK293 and neuroblastoma SH-SY5Ycells. However, no neuroprotective effect was observed for DL76 in hydrogen peroxide-treated neuroblastoma SH-SY5Y cells. Furthermore, in vivo studies showed antiparkinsonian activity of DL76 in haloperidol-induced catalepsy (Cross Leg Position Test) at a dose of 50 mg/kg body weight.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 106-52-5 is helpful to your research. Recommanded Product: 1-Methylpiperidin-4-ol.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem