Related Products of 4727-72-4, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4727-72-4, Name is 1-Benzylpiperidin-4-ol, molecular formula is C12H17NO. In a Article，once mentioned of 4727-72-4
Aim: The sigma1 receptor is a druggable target involved in many physiological processes and diseases. To clarify its physiology and derive therapeutic benefit, nine analogs based on the sigma1 antagonist PB212 were synthesized replacing the 4-methylpiperidine with basic moieties of varying size and degree of conformational freedom. Results & methodology: 3-Phenylpyrrolidine, 4-phenylpiperidine or granatane derivatives displayed the highest affinity (Ki. = 0.12, 0.31 or 1.03 nM). Calcium flux assays in MCF7sigma1 cells indicated that the highest sigma1 receptor affinity are sigma1 antagonists. Molecular models provided a structural basis for understanding the sigma1 affinity and functional activity of the analogs and incorporated Glennon’s sigma1 pharmacophore model. Conclusion: Herein, we identify new compounds exploitable as therapeutic drug leads or as tools to study sigma1 receptor physiology.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Related Products of 4727-72-4, you can also check out more blogs about4727-72-4
Reference：
Piperidine – Wikipedia,
Piperidine | C5H12733N – PubChem