Synthetic studies on homophymine B: solid phase synthesis of a cyclic fragment was written by Tokairin, Yoshinori;Takeda, Sho;Kikuchi, Mari;Konno, Hiroyuki. And the article was included in Tetrahedron Letters in 2015.Synthetic Route of C21H21NO4 The following contents are mentioned in the article:
The synthesis of a cyclic fragment of homophymine B is described. Fmoc-derivatives (Fmoc = 9-fluorenylmethoxycarbonyl) of βMOT and AHDH, which were necessary unusual amino acids for a designed cyclic depsipeptide, were prepared The linear peptides were synthesized using Fmoc-based solid phase peptide synthesis. The designed cyclic depsipeptide was constructed via the macrolactamization between the Pip and
(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Synthetic Route of C21H21NO4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem