Structure-Cytotoxicity Relationships of Analogues of N14-Desacetoxytubulysin H was written by Toader, Dorin;Wang, Fengjiang;Gingipalli, Lakshmaiah;Vasbinder, Melissa;Roth, Mark;Mao, Shenlan;Block, Michael;Harper, Jay;Thota, Sambaiah;Su, Mei;Ma, Jianquo;Bedian, Vahe;Kamal, Adeela. And the article was included in Journal of Medicinal Chemistry in 2016.HPLC of Formula: 41447-17-0 This article mentions the following:
Herein the authors report structure-cytotoxicity relationships for analogs of N14-Desacetoxytubulyisn H (1). A novel synthetic approach towards 1 enabled the discovery of compounds with a range of activity. Calculated basicity of the N-terminus of tubulysins was shown to be a good predictor of cytotoxicity. The impact of structural modifications at the C-terminus of 1 upon cytotoxicity is also described. These findings will facilitate the development of new tubulysin analogs for the treatment of cancer. In the experiment, the researchers used many compounds, for example, (R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0HPLC of Formula: 41447-17-0).
(R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.HPLC of Formula: 41447-17-0
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem