On September 3, 1998, Thorsett, Eugene D.; Porter, Warren J.; Nissen, Jeffrey S.; Latimer, Lee H.; Audia, James E.; Droste, James J. published a patent.COA of Formula: C10H18N2O3 The title of the patent was Preparation of heterocyclic compounds and their use for inhibiting β-amyloid peptide release. And the patent contained the following:
Disclosed are modified heterocyclic di- and tripeptide analogs which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer’s disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer’s disease both prophylactically and therapeutically with such pharmaceutical compositions Title compounds, e.g. I, were prepared in a multistep synthesis and inhibited β-amyloid peptide production by at least 30% as compared to control. The experimental process involved the reaction of (S)-tert-Butyl (2-oxopiperidin-4-yl)carbamate(cas: 1055049-80-3).COA of Formula: C10H18N2O3
The Article related to heterocyclic peptide preparation inhibitor amyloid release, alzheimer treatment heterocyclic compound preparation, amyloid peptide release inhibitor heterocyclic compound and other aspects.COA of Formula: C10H18N2O3
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem