In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 73874-95-0, name is tert-Butyl piperidin-4-ylcarbamate, introducing its new discovery. Recommanded Product: tert-Butyl piperidin-4-ylcarbamate
A new series of 12-benzyl matrinic amide/ethanamide derivatives were synthesized from matrinine (1) and evaluated for their anti-HCV activity, taking compound 2 as the lead. SAR revealed that the introduction of a suitable substituent at the N?-end of matrinic amide might greatly enhance the potency. Among them, matrinic acid 17 and N?-substituted matrinic amides 18a?d exhibited promising potency with low micromolar EC50values ranging from 1.03 mumol/L to 7.54 mumol/L, and better therapeutic window with SI from 66 to 132. Moreover, compound 17 displayed an excellent PK and safety profile in vivo, demonstrating good drug-like characteristics. Thus, it has been selected for further investigation, with an advantage of decreased chances of inducing drug-resistance mutations.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 73874-95-0 is helpful to your research. Recommanded Product: tert-Butyl piperidin-4-ylcarbamate
Reference：
Piperidine – Wikipedia,
Piperidine | C5H14425N – PubChem