In an article, author is Salgado, Mateo M., once mentioned the application of 143900-44-1, Name is (S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate, molecular formula is C10H19NO3, molecular weight is 201.26, MDL number is MFCD04115307, category is piperidines. Now introduce a scientific discovery about this category, Recommanded Product: (S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate.
Asymmetric Synthesis of 2,3,6-Trisubstituted Piperidines via Baylis-Hillman Adducts and Lithium Amide through Domino Reaction
A convenient asymmetric synthesis of methyl (2S,3S,6R)-6-(4-fluorophenyl)-2-(4-hydroxyphenyl)-piperidine-3-carboxylate is described, starting from Baylis-Hillman adducts. The route involves a domino process: allylic acetate rearrangement, stereoselective IrelandClaisen rearrangement and asymmetric Michael addition, which provides a.-amino acid derivative with full stereochemical control. A subsequent chemoselective transformation of one of the side-chain groups allows an effective cyclization leading to biologically interesting polysubstituted piperidines in which the 2,6-aryl groups could be attached sequentially.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem