Because a catalyst decreases the height of the energy barrier, 41838-46-4, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.41838-46-4, Name is 4-Amino-1-methylpiperidine, molecular formula is C6H14N2. In a article£¬once mentioned of 41838-46-4
Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47
Inhibitors of the cancer-related cysteine isopeptidase human ubiquitin-specific proteases 7 (USP7) and 47 (USP47) are considered to have potential as cancer therapeutics, owing to their ability to stabilize the tumor suppressor p53 and to decrease DNA polymerase beta(Polbeta), both of which are potential anticancer effects. A new class of dual small molecule inhibitors of these enzymes has been discovered. Compound 1, a selective inhibitor of USP7 and USP47 with moderate potency, demonstrates inhibition of USP7 in cells and induces elevated p53 and apoptosis in cancer cell lines. Compound 1 has been shown to demonstrate modest activity in human xenograft multiple myeloma and B-cell leukemia in vivo models. This activity may be the result of dual inhibition of USP7 and USP47. To address issues regarding potency and developability, analogues of compound 1 have been synthesized and tested, leading to improvements in potency, solubility, and metabolic reactivity profile. Further optimization is expected to yield preclinical candidates and, ultimately, clinical candidates for the treatment of multiple myeloma, prostate cancer, and other cancers.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. 41838-46-4, In my other articles, you can also check out more blogs about 41838-46-4
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H1976N – PubChem