Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 600-05-5, is researched, Molecular C3H4Br2O2, about Mutagenic activation of tris(2,3-dibromopropyl)phosphate: the role of microsomal oxidative metabolism, the main research direction is Salmonella mutation tris dibromopropylphosphate; mutagen metabolic activation flame retardant.Related Products of 600-05-5.
The flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) [126-72-7] was converted to products which were mutagenic for Salmonella typhimurium TA 100 in the presence of rat liver microsomes, NADPH, and O. Other bromopropyl compounds were also mutagenic; 2,3-dibromopropene [513-31-5] and 2,3-dibromopropionic acid [600-05-5] were directly mutagenic, whereas 2,3-dibromopropanol [96-13-9] and tris(2-bromopropyl)phosphate [31858-09-0] were weakly mutagenic after addition of liver microsomes and cofactors. Typical in vivo and in vitro inhibitors of cytochrome P-450 inhibited Tris-BP mutagenicity. The effects of inducers of cytochrome P-450 on Tris-BP mutagenicity was dependent on the concentration of mutagen and microsomal protein in the assay, indicating complexity in the kinetics involved when dealing with possible multiple paths that lead to mutagenicity. Addition of glutathione strongly inhibited Tris-BP mutagenicity. Tris-BP may be oxidized to a reactive electrophile, possibly the 2-keto derivative, which could react with nucleophilic groups in DNA and thus lead to mutagenic events.
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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem