Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zhurnal Fizicheskoi Khimii called Difference in the dissociation constants for polymorphic modifications of acids in nonaqueous solutions, Author is Urazovskii, S. S.; Kotlyarenko, I. P.; Kuris’ko, A. I., which mentions a compound: 600-05-5, SMILESS is O=C(O)C(Br)CBr, Molecular C3H4Br2O2, COA of Formula: C3H4Br2O2.
The dissociation constants were determined for the various modifications of monochloroacetic (I), glycolic (II), and α,β-dibromopropionic (III) acids in nonaqueous solutions (EtOH, Me2CO, C2H4Cl2) by the potentiometric and conductometric methods. Differences were observed in the dissociation constants for the stable and unstable modifications and the magnitudes for these differences coincided for the different methods of determination The differences in pK increased with a decrease in the dielec. constant of the solvent and with an increase in the concentration of the solution The constants remained unchanged only for dilute solutions beginning with 0.005N. In this range of concentration there was an equality between the ratios of the conductivity and the activity coefficient The observed phenomena were explained on the basis of the differences in the mol. configuration of the individual modifications of the acids owing to the hindered rotation of the OH groups which leads to different forms of association, i.e., intramol. for the β-modification and intermol. (dimeric) for the α-form.
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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem