Application of 41979-39-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 41979-39-9, Name is Piperidin-4-one hydrochloride, SMILES is O=C1CCNCC1.[H]Cl, belongs to piperidines compound. In a article, author is Qu, Bo, introduce new discover of the category.
Enantioselective Synthesis of alpha-(Hetero)aryl Piperidines through Asymmetric Hydrogenation of Pyridinium Salts and Its Mechanistic Insights
Enantioselective synthesis of alpha-aryl and alpha-heteroaryl piperidines is reported. The key step is an iridium-catalyzed asymmetric hydrogenation of substituted N-benzylpyridinium salts. High levels of enantioselectivity up to 99.3:0.7 er were obtained for a range of alpha-heteroaryl piperidines. DFT calculations support an outersphere dissociative mechanism for the pyridinium reduction. Notably, initial protonation of the final enamine intermediate determines the stereochemical outcome of the transformation rather than hydride reduction of the resultant iminium intermediate.
Application of 41979-39-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 41979-39-9.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem