Application of 39546-32-2, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 39546-32-2, Name is Piperidine-4-carboxamide, molecular formula is C6H12N2O. In a Article，once mentioned of 39546-32-2
A novel series of hybrid molecules were designed and synthesized by fusing the pharmacophoric features of cholinesterase inhibitor donepezil and diarylthiazole as potential multitarget-directed ligands for the treatment of Alzheimer’s disease (AD). The compounds showed significant in vitro anticholinesterase (anti-ChE) activity, the most potent compound (44) among them showing the highest activity (IC50 value of 0.30 ± 0.01 muM) for AChE and (1.84 ± 0.03 muM) for BuChE. Compound 44 showed mixed inhibition of AChE in the enzyme kinetic studies. Some compounds exhibited moderate to high inhibition of AChE-induced Abeta1-42 aggregation and noticeable in vitro antioxidant and antiapoptotic properties. Compound 44 showed significant in vivo anti-ChE and antioxidant activities. Furthermore, compound 44 demonstrated in vivo neuroprotection by decreasing Abeta1-42-induced toxicity by attenuating abnormal levels of Abeta1-42, p-Tau, cleaved caspase-3, and cleaved PARP proteins. Compound 44 exhibited good oral absorption and was well tolerated up to 2000 mg/kg, po, dose without showing toxic effects.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application of 39546-32-2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 39546-32-2, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H3642N – PubChem