Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 34737-89-8, Name is 1-Benzyl-3-methylpiperidin-4-one, SMILES is O=C1C(C)CN(CC2=CC=CC=C2)CC1, belongs to piperidines compound. In a document, author is Nguyen, Khiem Chau, introduce the new discover, Application In Synthesis of 1-Benzyl-3-methylpiperidin-4-one.
Study of conditions for streamlined assembly of a model bacteriochlorophyll from two dihydrodipyrrin halves
A long-term goal is to gain synthetic access to native photosynthetic bacteriochlorophylls. A recently developed route entails Knoevenagel condensation of an AD dihydrodipyrrin (I, bearing a carboxaldehyde attached to pyrroline ring D) and a BC dihydrodipyrrin (II, bearing a beta-ketoester attached to pyrrole ring C) to form the Z/E-enone. Acid-mediated double-ring closure of the E-enone III-E (Nazarov cyclization, electrophilic aromatic substitution, and elimination of methanol) affords the bacteriochlorophyll skeleton BC-1 containing the isocyclic ring (ring E), a trans-dialkyl group in ring D, and a gem-dimethyl group in ring B. Prior work established the synthesis and the integrity of the resulting trans-dialkyl groups and bacteriochlorin chromophore. The counterpart report here concerns an in-depth study of conditions for the double-ring closure: catalyst/solvent surveys; grid search including time courses of [III-E] versus [acid] concentrations emphasizing equimolar, inverse molar, and variable acid lines of inquiry; and chlorin byproduct quantitation. Key findings are that (1) the double-ring closure can be carried out in 4 h (t(1/2) similar to 40 min) instead of 20 h, affording similar to 1/5th the chlorin byproduct (0.16%) while maintaining the yield of BC-1 (up to 77%); (2) the separate Z/E-enones of III have comparable reactivity; (3) sub-stoichiometric quantities of acid are ineffective; (4) the Knoevenagel condensation (40 mM, room temperature, piperidine/acetic acid in acetonitrile) and the acid-mediated double-ring closure (0.20 mM, 80 degrees C, Yb(OTf)(3) in acetonitrile) can be carried out in a two-step process; and (5) zinc insertion to form ZnBC-1 is straightforward. Together, the results enable streamlined conversion of dihydrodipyrrin reactants to the bacteriochlorophyll model compounds.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 34737-89-8 is helpful to your research. Application In Synthesis of 1-Benzyl-3-methylpiperidin-4-one.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem