Synthetic Route of 3040-44-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3040-44-6, Name is 1-(2-Hydroxyethyl)piperidine, molecular formula is C7H15NO. In a Article£¬once mentioned of 3040-44-6
Pyrazolo[3,4-: D] pyrimidines as sigma-1 receptor ligands for the treatment of pain. Part 2: Introduction of cyclic substituents in position 4
The replacement of acylamino by cyclic substituents in the position 4 of the pyrazolo[3,4-d]pyrimidine scaffold, led to highly active sigma-1 receptor (sigma1R) ligands. Phenyl or pyrazolyl groups were the best in terms of affinity for the sigma1R and the 4-(1-methylpyrazol-5-yl) derivative, 12f, was the most selective. Compound 12f is also one of the best sigma1R ligands ever described in terms of lipophilic ligand efficiency, which translates into a good physicochemical and ADMET profile. In addition, 12f was identified as an antagonist of the sigma1R in view of its potent antinociceptive profile in several pain models in mice.
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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H5168N – PubChem