Alkenylation and arylation of peptides via Ni-catalyzed reductive coupling of α-C-tosyl peptides with Csp2 triflates/halides was written by Tao, Xianghua;Ma, Guobin;Song, Yanhong;Chen, Yunrong;Qian, Qun;Sun, Deli;Gong, Hegui. And the article was included in Organic Letters in 2021.Safety of 1-Tosylpiperidin-4-one This article mentions the following:
A Ni-catalyzed reductive cross-coupling between α-C-tosyl peptides and Csp2 triflates/halides has been developed. This protocol enables the formation of various unnatural di- and tripeptides containing vinyl and aryl side chains, and it expands the applications of Ni-catalyzed reductive cross-coupling in late-stage diversification of peptides. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9Safety of 1-Tosylpiperidin-4-one).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Safety of 1-Tosylpiperidin-4-one
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem