Tag: M.W=600-700

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Angewandte Chemie, International Edition called Alkylation-Terminated Catellani Reactions Using Alkyl Carbagermatranes, Author is Jiang, Wei-Tao; Xu, Meng-Yu; Yang, Shuo; Xie, Xiu-Ying; Xiao, Bin, which mentions a compound: 175136-62-6, SMILESS is FC(C1=CC(C(F)(F)F)=CC(P(C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=C1)(F)F, Molecular C24H9F18P, Quality Control of Tris(3,5-bis(trifluoromethyl)phenyl)phosphine.

The Catellani reaction has received substantial attention because it enables rapid multiple derivatization on aromatics While using alkyl electrophiles to achieve ortho-alkylation was one of the earliest applications of the Catellani reaction, ipso-alkylation-terminated reactions with β-H-containing reactants has not been realized to date. Herein, we report alkylation-terminated Catellani reaction using alkyl carbagermatranes (abbreviated as alkyl-Ge) as nucleophiles. The reactivity of alkyl-Ge and alkyl-B(OH)2 in this reaction is discussed. This approach enables efficient dialkylation with β-H-containing reactants, which was previously inaccessible by Catellani reactions.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lee, Yong Ho; Denton, Elliott H.; Morandi, Bill researched the compound: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine( cas:175136-62-6 ).Category: piperidines.They published the article 《Modular Cyclopentenone Synthesis through the Catalytic Molecular Shuffling of Unsaturated Acid Chlorides and Alkynes》 about this compound( cas:175136-62-6 ) in Journal of the American Chemical Society. Keywords: acid chloride unsaturated alkyne internal hydrosilane palladium cyclization catalyst; cyclopentenone preparation. We’ll tell you more about this compound (cas:175136-62-6).

We describe a general strategy for the intermol. synthesis of polysubstituted cyclopentenones using palladium catalysis. Overall, this reaction is achieved via a mol. shuffling process involving an alkyne, an α,β-unsaturated acid chloride, which serves as both the alkene and carbon monoxide source, and a hydrosilane to create three new C-C bonds. This new carbon monoxide-free pathway delivers the products with excellent yields. Furthermore, the regioselectivity is complementary to conventional methods for cyclopentenone synthesis. In addition, a set of regio- and chemodivergent reactions are presented to emphasize the synthetic potential of this novel strategy.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Related Products of 175136-62-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine, is researched, Molecular C24H9F18P, CAS is 175136-62-6, about A phosphine gold(I) π-alkyne complex: tuning the metal-alkyne bond character and counterion position by the choice of the ancillary ligand. Author is Zuccaccia, Daniele; Belpassi, Leonardo; Rocchigiani, Luca; Tarantelli, Francesco; Macchioni, Alceo.

Gold-alkyne bonding was investigated in dependence on an ancillary ligands, electron-deficient phosphine and 2-imidazolylidene NHC carbene, by NMR spectroscopy and DFT calculations The intra- and interionic structures of a mononuclear phosphine gold(I) alkyne complex [(PArF3)Au(2-hexyne)]BF4 [1·BF4; ArF = 3,5-(CF3)2C6H3] and its analogous complex [(NHC)Au(2-hexyne)]BF4 [2·BF4; NHC = 1,3-bis(diisopropylphenyl)imidazol-2-ylidene] have been investigated by combining 1D and 2D multinuclear NMR spectroscopy and d. functional theory calculations It has been found that alkyne in 1·BF4 is depleted of its electron d. to a greater extent than that in 2·BF4. This correlates with the Δδ(13C) NMR of the carbon-carbon triple bond. Instead, 2·BF4 is much more kinetically stable than 1·BF4. NMR 19F-1H HOESY spectra indicate that the counterion locates close to the gold atom in 1·BF4 (differently from that previously observed in the few other gold(I) ion pairs studied), exactly where the computed Coulomb potential indicates that partial pos. charge accumulates.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Organic Letters called Palladium Catalyzed Cyclizations of Oxime Esters with 1,2-Disubstituted Alkenes: Synthesis of Dihydropyrroles, Author is Race, Nicholas J.; Bower, John F., which mentions a compound: 175136-62-6, SMILESS is FC(C1=CC(C(F)(F)F)=CC(P(C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=C1)(F)F, Molecular C24H9F18P, Recommanded Product: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine.

Pd-catalyzed cyclizations of oxime esters with 1,2-dialkylated alkenes provide an entry to chiral dihydropyrroles. Substrate and catalyst controlled strategies for selective product formation (vs. alternative pyrroles) are outlined.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Statistical Modeling of a Ligand Knowledge Base, published in 2006-12-31, which mentions a compound: 175136-62-6, mainly applied to statistical analysis linear regression ligand phosphorus, Safety of Tris(3,5-bis(trifluoromethyl)phenyl)phosphine.

A range of different statistical models has been fitted to exptl. data for the Tolman electronic parameter (TEP) based on a large set of calculated descriptors in a prototype ligand knowledge base (LKB) of phosphorus(III) donor ligands. The models have been fitted by ordinary least squares using subsets of descriptors, principal component regression, and partial least squares which use variables derived from the complete set of descriptors, least angle regression, and the least absolute shrinkage and selection operator. None of these methods is robust against outliers, so we also applied a robust estimation procedure to the linear regression model. Criteria for model evaluation and comparison have been discussed, highlighting the importance of resampling methods for assessing the robustness of models and the scope for making predictions in chem. intuitive models. For the ligands covered by this LKB, ordinary least squares models of descriptor subsets provide a good representation of the data, while partial least squares, principal component regression, and least angle regression models are less suitable for our dual aims of prediction and interpretation. A linear regression model with robustly fitted parameters achieves the best model performance over all classes of models fitted to TEP data, and the weightings assigned to ligands during the robust estimation procedure are chem. intuitive. The increased model complexity when compared to the ordinary least squares linear model is justified by the reduced influence of individual ligands on the model parameters and predictions of new ligands. Robust linear regression models therefore represent the best compromise for achieving statistical robustness in simple, chem. meaningful models.

After consulting a lot of data, we found that this compound(175136-62-6)Safety of Tris(3,5-bis(trifluoromethyl)phenyl)phosphine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 175136-62-6, is researched, SMILESS is FC(C1=CC(C(F)(F)F)=CC(P(C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=C1)(F)F, Molecular C24H9F18PJournal, Article, Research Support, Non-U.S. Gov’t, Inorganic Chemistry called Anticancer C,N-Cycloplatinated(II) Complexes Containing Fluorinated Phosphine Ligands: Synthesis, Structural Characterization, and Biological Activity, Author is Cutillas, Natalia; Martinez, Alexandra; Yellol, Gorakh S.; Rodriguez, Venancio; Zamora, Ana; Pedreno, Monica; Donaire, Antonio; Janiak, Christoph; Ruiz, Jose, the main research direction is platinum cyclometalated dimethylbenzylamine fluorophosphine complex preparation anticancer biol activity; fluorophosphine platinum antitumor human breast ovary cathepsin B inhibitor; crystal structure mol platinum cyclometalated dimethylbenzylamine fluorinated phosphine complex.Synthetic Route of C24H9F18P.

A series of potent C,N-cycloplatinated-(II) phosphine antitumor complexes containing fluorous substituents in the cyclometalated or the ancillary phosphine ligands [Pt-(C-N)-(PR3)-Cl] or both have been synthesized and characterized. The crystal structure of [Pt-(dmba)-{P-(C6H4CF3-p)3}-Cl]·2CH2Cl2 (dmba = dimethylaminomethyl-phenyl) has been established by X-ray diffraction. Values of IC50 of the new platinum complexes were calculated toward a panel of human tumor cell lines representative of ovarian (A2780 and A2780cisR) and breast cancers (T47D). Complexes containing P-(C6H4CF3-p)3 as ancillary ligand (with a bulky and electroneg. CF3 substituent in para position) were the most cytotoxic compounds in all the tested cancer cell lines. In some cases, the IC50 values were 16-fold smaller than that of cisplatin and 11-fold smaller than the non-fluorous analog [Pt-(dmba)-(PPh3)-Cl]. On the other hand, very low resistance factors (RF) in A2780cisR (cisplatin-resistant ovarian carcinoma) at 48 h were observed (RF ≈ 1) for most of the new compounds Anal. of cell cycle was done for the three more active compounds in A2780. They arrest cell growth in G0/G1 phase in contrast to cisplatin (S phase) with a high incidence of late-stage apoptosis. They are also good cathepsin B inhibitors (an enzyme implicated in a number of cancer related events).

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Application In Synthesis of Tris(3,5-bis(trifluoromethyl)phenyl)phosphine. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine, is researched, Molecular C24H9F18P, CAS is 175136-62-6, about Synthesis and characterization of trisarylphosphine selenides: further insight into the effect of fluoroalkylation on the electronic properties of trisarylphosphines. Author is Adams, Dave J.; Bennett, James A.; Duncan, Daniel; Hope, Eric G.; Hopewell, Jonathan; Stuart, Alison M.; West, Andrew J..

Variations in the magnitude of the 1JSeP coupling constants for a range of P(V) selenides, e.g., Ph3-nP(Se)(C6H4R)n (I, n = 1,2,3, R = CF3, C6F13, C8F17, C2H4C6F13) and Pt complexes, e.g., PtCl2L2 [II, L = Ph3-nP(C6H4R)n], allow the efficiency of different spacer groups at insulating the P center in triarylphosphines from highly electron-withdrawing perfluoroalkyl groups to be established. I were prepared from reactions of the arylphosphines, e.g., Ph3-nP(C6H4R)n, with selenium powder in chloroform at 70°; II were prepared from the reactions of arylphosphines with PtCl2(CH3CN)2 in CH2Cl2 under reflux.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Recommanded Product: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine, is researched, Molecular C24H9F18P, CAS is 175136-62-6, about Highly Efficient Narasaka-Heck Cyclizations Mediated by P(3,5-(CF3)2C6H3)3: Facile Access to N-Heterobicyclic Scaffolds. Author is Faulkner, Adele; Bower, John F..

Highly efficient palladium-catalyzed cyclizations of oxime esters with cyclic alkenes were used as a general entry to perhydroindole and related scaffolds. The chem. is reliant upon the use of P(3,5-(CF3)2C6H3)3 for the key C(sp3)-N bond-forming process and this facilitates cyclizations with enhanced levels of efficiency across a range of sterically and electronically distinct substrates.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Selectively Measuring π Back-Donation in Gold(I) Complexes by NMR Spectroscopy, published in 2015, which mentions a compound: 175136-62-6, mainly applied to gold complex NMR Eyring plot Tolman electronic parameter DFT; NMR spectroscopy; bond theory; density functional calculations; gold; ligands, Application of 175136-62-6.

Even though the Dewar-Chatt-Duncanson model has been successfully used by chemists since the 1950s, no exptl. methodol. is yet known to unambiguously estimate the constituents (donation and back-donation) of a metal-ligand interaction. It is demonstrated here that one of these components, the metal-to-ligand π back-donation, can be effectively probed by NMR measurements aimed at determining the rotational barrier of a C-N bond (ΔHr≠) of a nitrogen acyclic carbene ligand. A large series of gold(I) complexes have been synthesized and analyzed, and it was found that the above exptl. observables show an accurate correlation with back-donation, as defined theor. by the appropriate charge displacement originated upon bond formation. The proposed method is potentially of wide applicability for analyzing the ligand effect in metal catalysts and guiding their design.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Preparation of Organozinc Reagents via Catalyst Controlled Three-Component Coupling between Alkyne, Iodoarene, and Bis(iodozincio)methane, published in 2017-07-07, which mentions a compound: 175136-62-6, mainly applied to organozinc alkenylzinc reagent preparation protonation boration; alkyne three component coupling iodoarene iodozinciomethane, Application of 175136-62-6.

Three-component coupling between an alkyne, iodoarene, and bis(iodozincio)methane yields allylic Zn with a tetrasubstituted alkene moiety in the presence of a Ni catalyst. The reaction proceeds via aryl nickelation of the alkyne and subsequent cross-coupling with bis(iodozincio)methane. Meanwhile, the same combination in the presence of a Pd and Co catalyst gives tetrasubstituted alkenylzinc. The reaction proceeds via a Pd-catalyzed cross-coupling of iodoarene with bis(iodozincio)methane followed by a Co-catalyzed benzylzincation of alkyne.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem