Tag: M.W=500-600

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Jin, Jian, once mentioned the application of 201341-05-1, Name is Tenofovir disoproxil, molecular formula is C19H30N5O10P, molecular weight is 519.44, MDL number is MFCD00952920, category is piperidines. Now introduce a scientific discovery about this category, Name: Tenofovir disoproxil.

Isoquinolinone derivatives as potent CNS multi-receptor D-2/5-HT1A/5HT(2A)/5-HT6/5-HT7 agents: Synthesis and pharmacological evaluation

In this study, a series of novel Isoquinolinone derivatives were synthesized as potential multi-target antipsychotics. Among these, compound 13 showed high affinity for dopamine D-2 and serotonin 5-HT1A, 5-HT2A, 5-HT6, and 5-HT7 receptors, showed low affinity for off-target receptors (5-HT2C, H-1, and alpha(1)), and negligible effects on ether-a-gogo-related gene (hERG; i.e., reduced QT interval prolongation). An animal behavioral study revealed that compound 13 reversed APO-induced hyperlocomotion, MK-801-induced hyperactivity, and DOI-induced head twitch. Moreover, compound 13 exhibited a high threshold for acute toxicity, a lack of tendency to induce catalepsy, and did not cause prolactin secretion or weight gain when compared to risperidone. Furthermore, in the forced swim test, tail suspension test, and novel object recognition test, treatment with compound 13 resulted in improvements in depression and cognitive impairment. In addition, compound 13 had a favorable pharmacokinetic profile in rats. Thus, the antipsychotic drug-like effects of compound 13 indicate that it may be useful for developing a novel class of drugs for the treatment of schizophrenia. (C) 2020 Elsevier Masson SAS. All rights reserved.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, SMILES is O=C(OC1CC(C)(C)N(C)C(C)(C)C1)CCCCCCCCC(OC2CC(C)(C)N(C)C(C)(C)C2)=O, in an article , author is Wang, Darui, once mentioned of 41556-26-7, Application In Synthesis of Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate.

Hierarchical ZSM-5 zeolite with radial mesopores: Preparation, formation mechanism and application for benzene alkylation

Hierarchical ZSM-5 zeolite with radial mesopores is controllably synthesized using piperidine in a NaOH solution. The piperidine molecules enter the zeolite micropores and protect the zeolite framework from extensive desilication. The areas containing fewer aluminum atoms contain fewer piperidine protectant molecules and so they dissolve first. Small amounts of mesopores are then gradually generated in areas with more aluminum atoms and more piperidine protectant. In this manner, radial mesopores are formed in the ZSM-5 zeolite with a maximal preservation of the micropores and active sites. The optimal hierarchical ZSM-5 zeolite, prepared with a molar ratio of piperidine to zeolite of 0.03, had a mesopore surface area of 136 m(2)center dot g(-1) and a solid yield of 80%. The incorporation of the radial mesopores results in micropores that are interconnected which shortened the average diffusion path length. Compared to the parent zeolite, the hierarchical ZSM-5 zeolite possesses more accessible acid sites and has a higher catalytic activity and a longer lifetime for the alkylation of benzene.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C19H30N5O10P, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 201341-05-1, Name is Tenofovir disoproxil, molecular formula is C19H30N5O10P. In an article, author is Summart, Ratasark,once mentioned of 201341-05-1.

Superiority of an Asymmetric Perylene Diimide in Terms of Hydrosolubility, G-Quadruplex Binding, Cellular Uptake, and Telomerase Inhibition in Prostate Cancer Cells

Perylene diimide (PDI) derivatives have been studied as G-quadruplex ligands that suppress telomerase activity by facilitating G-quadruplex formation of telomeric DNA and the hTERT promoter. PIPER, the prototypical PDI, reduces telomerase activity in lung and prostate cancer cells, leading to telomere shortening and cellular senescence of these cells. However, PIPER suffers from poor hydrosolubility and the propensity to aggregate at neutral pH. In this report, we synthesized a new asymmetric PDI, aPDI-PHis, which maintains one N-ethyl piperidine side chain of PIPER and has histidine as another side chain. The results show that aPDI-PHis is superior to its symmetric counterparts, PIPER and PDI-His, in terms of hydrosolubility, G-quadruplex binding, cellular uptake, and telomerase inhibition in prostate cancer cells. These results suggest that one N-ethyl piperidine side chain of PDI is sufficient for G-quadruplex binding, while another side chain can be tuned to elicit desirable properties. These findings might lead to better PDIs for use as anticancer drugs.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Electric Literature of 41556-26-7, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, SMILES is O=C(OC1CC(C)(C)N(C)C(C)(C)C1)CCCCCCCCC(OC2CC(C)(C)N(C)C(C)(C)C2)=O, belongs to piperidines compound. In a article, author is Petrov, O. A., introduce new discover of the category.

Kinetic Features of the Formation of Zinc Complex with Hexa(m-Trifluoromethylphenyl)benzoporphyrazine in a Nitrogen-Containing Base-Benzene System

The effect n-butylamine, tert-butylamine, piperidine, and morpholine additives have on the kinetics of complex formation between zinc acetate and hexa(m-trifluoromethylphenyl)benzoporphyrazine in benzene is studied. A possible scheme for their complexation is proposed. It is established that the rate and activation parameters of the process are affected by the proton-acceptor capacity of the base and its spatial structure.

Electric Literature of 41556-26-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 41556-26-7.

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Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

In an article, author is Marinic, Bruno, once mentioned the application of 201341-05-1, SDS of cas: 201341-05-1, Name is Tenofovir disoproxil, molecular formula is C19H30N5O10P, molecular weight is 519.44, MDL number is MFCD00952920, category is piperidines. Now introduce a scientific discovery about this category.

Single point activation of pyridines enables reductive hydroxymethylation

The single point activation of pyridines, using an electron-deficient benzyl group, facilitates the ruthenium-catalysed dearomative functionalisation of a range of electronically diverse pyridine derivatives. This transformation delivers hydroxymethylated piperidines in good yields, allowing rapid access to medicinally relevant small heterocycles. A noteworthy feature of this work is that paraformaldehyde acts as both a hydride donor and an electrophile in the reaction, enabling the use of cheap and readily available feedstock chemicals. Removal of the activating group can be achieved readily, furnishing the free NH compound in only 2 steps. The synthetic utility of the method was illustrated with a synthesis of (+/-)-Paroxetine.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 201341-05-1, 201341-05-1, Name is Tenofovir disoproxil, SMILES is O=C(OC(C)C)OCOP(OCOC(OC(C)C)=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)=O, belongs to piperidines compound. In a document, author is Islam, Mohammad Jahirul, introduce the new discover.

Sterically encumbered dianionic dicarboranyl pincer ligand (C5H3N)(C2B10H11)(2) and its CNC Nickel(II) complex

The novel 2,6-bis(carborane) pyridine (C5H3N)(C2B10H11)(2) ligand precursor containing two icosahedral carborane clusters attached to the pyridine ring was synthesized by the SNAr reaction between 2,6-difluoropyridine and lithiated ortho-carborane LiC2B10H11. Lithiation of the proligand at carbon atoms of carborane cages and the subsequent reaction with Ni(PPh3)(2)Cl-2 afforded the square-planar Ni(II) pincer complex {(C5H3N)(C2B10H10)(2)} Ni(CH3CN). X-ray single crystal diffraction revealed extreme steric hindrance around the metal center in the complex imposed by two carboranyl groups in the rigid pincertype framework, which was also manifested by the high value of the ligand buried volume % V-bur = 70.6%. The title pincer complex {(C5H3N)(C2B10H10)(2)} Ni(CH3CN) was found to be a competent catalyst for nucleophilic addition of piperidine to acetonitrile. (C) 2017 Elsevier B.V. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 201341-05-1. Recommanded Product: 201341-05-1.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

In an article, author is Vengatesh, Gopal, once mentioned the application of 41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, molecular formula is C30H56N2O4, molecular weight is 508.78, MDL number is MFCD00134706, category is piperidines. Now introduce a scientific discovery about this category, Product Details of 41556-26-7.

Ring opening of 2,6-diaryl-3,5-diphenyl piperidine-4-one by acetic acid: Structural studies and Hirshfeld surface analysis of (E)-4-aryl-1,3-diphenylbut-3-en-2-ones

Six alpha,beta-unsaturated carbonyl compounds have been obtained from 2,6-diaryl-3,5-diphenylpiperidine-4-one by the treatment with acetic acid. A plausible mechanism for the ring opening of 2,6-diaryl-3,5-diphenyl piperidin-4-ones is proposed. The resultant (E)-4-aryl-1,3-diphenylbut-3-en-2-ones have been characterized by H-1 and C-13 nuclear magnetic resonance (NMR) spectral studies. One of the compounds was completely characterized by 2D NMR techniques, and structure of the compound is further proved by single-crystal X-ray diffraction (XRD) analysis. The crystal structure, three-dimensional framework of crystal, and Hirshfeld surface analysis of two of the compounds have been discussed. In the crystals, molecules are mainly linked by C-H center dot center dot center dot O hydrogen bonding interactions, and this interaction forms an inversion dimer with R-2(1)(6) and R-2(1)(10) ring motifs in one of the compounds. Hirshfeld surface indicates the dominance of H center dot center dot center dot H contacts on the overall surface.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.201341-05-1, Name is Tenofovir disoproxil, SMILES is O=C(OC(C)C)OCOP(OCOC(OC(C)C)=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)=O, belongs to piperidines compound. In a document, author is Liu, Mengchen, introduce the new discover, Name: Tenofovir disoproxil.

Total synthesis of C-19-diterpenoid alkaloid: construction of a functionalized ABCDE-ring system

A synthetic approach for the ABCDE ring system of methyllycaconitine starting from a BCD tricycle precursor 14 was described. The synthesis features a useful strategy for the full functionalization of ring B, a 1,7-enyne reductive radical cyclization for the construction of ring A, and a straightforward double condensation for installation of the piperidine ring E.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 201341-05-1 is helpful to your research. Name: Tenofovir disoproxil.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, SMILES is O=C(OC1CC(C)(C)N(C)C(C)(C)C1)CCCCCCCCC(OC2CC(C)(C)N(C)C(C)(C)C2)=O, belongs to piperidines compound. In a document, author is Zhang, Zhao-Fei, introduce the new discover, SDS of cas: 41556-26-7.

N-Heterocyclic Carbene-Catalyzed Annulation of alpha-Chloroaldehydes with gamma-/delta-Amino-alpha,beta-Unsaturated Ketones: Enantioselective Synthesis of Pyrrolidones and Piperidones

The N-heterocyclic carbene-catalyzed [2+3] and [2+4] annulations of alpha-chloroaldehydes with gamma-/delta-amino-alpha,beta-unsaturated ketones were developed, giving the corresponding pyrrolidones and piperidones in good yields with exclusive trans-selectivities and excellent enantioselectivities.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 41556-26-7 is helpful to your research. SDS of cas: 41556-26-7.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reference of 201341-05-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 201341-05-1, Name is Tenofovir disoproxil, SMILES is O=C(OC(C)C)OCOP(OCOC(OC(C)C)=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)=O, belongs to piperidines compound. In a article, author is Kang, Min-A., introduce new discover of the category.

Highly sensitive and wearable gas sensors consisting of chemically functionalized graphene oxide assembled on cotton yarn

Highly sensitive and wearable chemical sensors for the detection of toxic gas molecules are given significant attention for a variety of applications in human health care and environmental safety. Herein, we demonstrated fiber-type gas sensors based on graphene oxide functionalized with organic molecules such as heptafluorobutylamine (HFBA), 1-(2-methoxyphenyl) piperazine (MPP), and 4-(2-keto-1-benzimidazolinyl) piperidine (KBIP) by assembling functionalized graphene oxide (FGO) on a single yarn fabric. These gas sensors of FGO on yarn exhibited extraordinarily higher sensitivity upon exposure to gas molecules than chemically reduced graphene oxide due to many active functional groups on the GO surface. Furthermore, the mechanical stability and chemical durability of the resulting gas sensors are well-maintained. Based on these results, we expected that our sensors with high sensitive and wearability will provide a good premise for wearable chemical sensors-based multidisciplinary applications.

Reference of 201341-05-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 201341-05-1 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem