Tag: M.W:400-500

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Product Details of 147770-06-7, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 147770-06-7, Name is (S)-Ethyl 2-ethoxy-4-(2-((3-methyl-1-(2-(piperidin-1-yl)phenyl)butyl)amino)-2-oxoethyl)benzoate, molecular formula is C29H40N2O4. In a Article, authors is Grell, Wolfgang，once mentioned of 147770-06-7

The structure-activity relationships in two series of hypoglycemic benzoic acid derivatives (5, 6) were investigated. Series 5 resulted from meglitinide (3) when the 2-methoxy was replaced by an alkyleneimino residue. Maximum activity was observed with the cis-3,5-dimethylpiperidino (5h) and the octamethyleneimino (5l) residues. Series 6 resulted from the meglitinide analogon 4 bearing an inversed amido function when the 2-methoxy, the 5- fluoro, and the alpha-methyl residue were replaced by a 2-piperidino, a 5- hydrogen, and a larger alpha-alkyl residue, respectively. An alkoxy residue ortho to the carboxy group further increased activity and duration of action in the rat. The most active racemic compound, 6al (R4 = isobutyl; R = ethoxy), turned out to be 12 times more active than the sulfonylurea (SU) glibenclamide (1). Activity was found to reside predominantly in the (S)- enantiomers. Compared with the SUs 1 and 2 (glimepiride), the most active enantiomer, (S)-6al (AG-EE 623 ZW; repaglinide; ED50 = 10 mug/kg po), is 25 and 18 times more active. Repaglinide turned out to be a useful therapeutic for type 2 diabetic patients; approval was granted recently by the FDA and the EMEA. From investigations on the pharmacophoric groups in compounds of type 5 and 6, it was concluded that in addition to the two already known – the acidic group (COOH; S02NH) and the amidic spacer (CONH; NHCO) – the ortho residue R1 (alkyleneimino; alkoxy; oxo) must be regarded as a third one. A general pharmacophore model suitable for hypoglycemic benzoic acid derivatives, SUs, and sulfonamides is proposed (Figure 6). Furthermore, from superpositions of low-energy conformations (LECs) of 1, 2, and (S)-6al, it was concluded that a common binding conformation (LEC II; Figure 10B) may exist and that differences in binding to the SU receptor and in the mechanism of insulin release between repaglinide and the two SUs may be due to specific hydrophobic differences.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Product Details of 147770-06-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H24027N – PubChem

 

Synthetic Route of 147770-06-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 147770-06-7, Name is (S)-Ethyl 2-ethoxy-4-(2-((3-methyl-1-(2-(piperidin-1-yl)phenyl)butyl)amino)-2-oxoethyl)benzoate, molecular formula is C29H40N2O4. In a Patent，once mentioned of 147770-06-7

The present invention provides highly pure repaglinide substantially free of dimer impurity, and process for the preparation thereof. The present invention also relates to 2-ethoxy-N-[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzamide, an impurity of repaglinide, and a process for preparing and isolating thereof. The present invention further relates to pharmaceutical compositions comprising solid particles of pure repaglinide substantially free of dimer impurity or pharmaceutically acceptable salts thereof, wherein 90 volume-percent of the particles (D90) have a size of less than about 400 microns. The present invention also provides an optical resolution method of racemic 3-methyl-1-(2-piperidino-phenyl)-1-butylamine and use thereof for the preparation of repaglinide.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Synthetic Route of 147770-06-7, you can also check out more blogs about147770-06-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H24030N – PubChem

 

Application of 503614-92-4, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 503614-92-4, name is 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid. In an article，Which mentioned a new discovery about 503614-92-4

A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. 1These compounds are useful as factor Xa inhibitors.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.503614-92-4. In my other articles, you can also check out more blogs about 503614-92-4

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Piperidine – Wikipedia,
Piperidine | C5H24026N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Recommanded Product: N1,N3-Bis(2,2,6,6-tetramethylpiperidin-4-yl)isophthalamide, Which mentioned a new discovery about 42774-15-2

The invention discloses an optical stabilizer N, N, -bis-(2, 2, 6, 6-tetramethyl-4-piperidinyl) isophthalamide synthetic method, is in order to m-phthaloyl chloride, 2, 2, 6, 6-tetramethyl-4-PIPERIDYLAMINES as raw materials, the presence of a solvent of the catalyst and reaction under the condition of N, N, -bis-(2, 2, 6, 6-tetramethyl-4-piperidinyl) isophthalamide. N the invention synthetic, N, -bis-(2, 2, 6, 6-tetramethyl-4-piperidinyl) isophthalamide, separating and purifying process is simple, short reaction time, can reach a product yield of 96% or more, high product purity, low energy consumption, environmental pollution is small, low cost, is to realize more ideal process of industrial production. (by machine translation)

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 42774-15-2, help many people in the next few years.Recommanded Product: N1,N3-Bis(2,2,6,6-tetramethylpiperidin-4-yl)isophthalamide

Reference：
Piperidine – Wikipedia,
Piperidine | C5H24006N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C27H31N5O2S, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 923036-30-0, Name is N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine, molecular formula is C27H31N5O2S. In a Review, authors is Faiz, Sadia£¬once mentioned of 923036-30-0

Ring opening of epoxides has been an area of interest for organic chemists, owing to their reactivity toward nucleophiles. Such reactions yield important products depending on the type of nucleophiles used. This review article covers the synthetic approaches (1991?2015) used for the ring opening of epoxides via carbon nucleophiles.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 923036-30-0, help many people in the next few years.COA of Formula: C27H31N5O2S

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H24145N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C27H31N5O2S, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 923036-30-0, Name is N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine, molecular formula is C27H31N5O2S. In a Review, authors is Faiz, Sadia£¬once mentioned of 923036-30-0

Ring opening of epoxides has been an area of interest for organic chemists, owing to their reactivity toward nucleophiles. Such reactions yield important products depending on the type of nucleophiles used. This review article covers the synthetic approaches (1991?2015) used for the ring opening of epoxides via carbon nucleophiles.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 923036-30-0, help many people in the next few years.COA of Formula: C27H31N5O2S

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H24145N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 124172-53-8, Name is N,N’-(Hexane-1,6-diyl)bis(N-(2,2,6,6-tetramethylpiperidin-4-yl)formamide), molecular formula is , belongs to piperidines compound. In a document, author is Kalinowska-Tluscik, Justyna, Name: N,N’-(Hexane-1,6-diyl)bis(N-(2,2,6,6-tetramethylpiperidin-4-yl)formamide).

Multifunctional arylsulfonamide derivatives with 5-HT6/5-HT7 receptor antagonistic activity: a structural study

Nowadays, a search for antagonists co-acting on serotonin receptor subtypes 6 and 7 (5-HT6R and 5-HT7R, respectively) is of great interest due to the increasing number of patients suffering from dementia and related behavioural and psychological symptoms. The X-ray crystal structures of four promising multifunctional ligands in the hydrochloride forms were determined, namely 4-(6-fluoro-1,2-benzoxazol-3-yl)-1-[3-(3-methylbenzenesulfonamido) propyl]piperidin-1-ium chloride, C22H27FN3O3S+center dot Cl-, (I), 4-(6-fluoro-1,2-benzoxazol-3-yl)-1-[4-(5-fluoro-3-methylbenzo[b]thiophene-2-sulfonamido) butyl] piperidin-1-ium chloride, C25H28F2N3O3S2+Cl-, (II), 4-(6-fluoro-1,2-benzoxazol-3-yl)-1-[4(6-fluorobenzo[b]thiophene-2-sulfonamido)butyl] piperidin-1-ium chloride, C24H26ClFN3O3S2+center dot Cl-, (III), and 4-(6-fluoro-1,2-benzoxazol-3-yl)-1-[3-(3-chloro4-fluorobenzenesulfonamido)propyl] piperidin-1-ium chloride, C21H22ClF2N3O3S2+center dot Cl-, (IV). Two pharmacologically important functional groups, i.e. arylsulfonamide and piperidinyl-fluorobenzisoxazole, are linked by three- and four-membered aliphatic chains. These compounds crystallize as hydrochloride salts in monoclinic space groups, i.e. C2/c for (I), P2(1)/c for (II) and (III), and P2(1/n) for (IV). In the asymmetric unit, a charge-assisted hydrogen bond is observed between the cation located at the piperidine N atom and the chloride anion. The protonated piperidine N atom is critical to the pharmacological activity for the compounds, allowing for a strong interaction with monoaminergic receptors in the central nervous system. The sulfonyl group plays the role of a hydrogen-bond acceptor in the pharmacophore model and is involved in several C-H center dot center dot center dot O interactions. Two aromatic fragments of the presented structures are involved in C-H center dot center dot center dot pi contacts, which were studied by Hirshfeld structure analysis. The distances between the mentioned functional groups are in agreement with pharmacophore models given in the literature. The studied interactions observed in the crystal structure indicate the main forces responsible for ligand-receptor recognition and binding.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 124172-53-8, in my other articles. Name: N,N’-(Hexane-1,6-diyl)bis(N-(2,2,6,6-tetramethylpiperidin-4-yl)formamide).

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 124172-53-8, 124172-53-8, Name is N,N’-(Hexane-1,6-diyl)bis(N-(2,2,6,6-tetramethylpiperidin-4-yl)formamide), SMILES is O=CN(CCCCCCN(C1CC(C)(C)NC(C)(C)C1)C=O)C2CC(C)(C)NC(C)(C)C2, in an article , author is Pratesi, Debora, once mentioned of 124172-53-8.

Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors

The synthesis of selective inhibitors of human carbonic anhydrases (hCAs) is of paramount importance to avoid side effects derived from undesired interactions with isoforms not involved in the targeted pathology, and this was partially addressed with the introduction of a sugar moiety (the so-called sugar approach). Since glycomimetics are considered more selective than the parent sugars in inhibiting carbohydrate-processing enzyme, we explored the possibility of further tuning the selectivity of hCAs inhibitors by combining the sulfonamide moiety with a sugar analogue residue. In particular, we report the synthesis of two novel hCAs inhibitors 2 and 3 which feature the presence of a piperidine iminosugar and an additional carbohydrate moiety derived from levoglucosenone (1), a key intermediate derived from cellulose pyrolysis. Biological assays revealed that iminosugar 2 is a very strong inhibitor of the central nervous system (CNS) abundantly expressed hCA VII (K-I of 7.4 nM) and showed a remarkable selectivity profile toward this isoform. Interestingly, the presence of levoglucosenone in glycomimetic 3 imparted a strong inhibitory activity toward the tumor associated hCA IX (K-I of 35.9 nM).

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 124172-53-8, you can contact me at any time and look forward to more communication. Recommanded Product: 124172-53-8.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 124172-53-8, Name is N,N’-(Hexane-1,6-diyl)bis(N-(2,2,6,6-tetramethylpiperidin-4-yl)formamide), formurla is C11H14N2O2. In a document, author is Dega-Szafran, Zofa, introducing its new discovery. Safety of N,N’-(Hexane-1,6-diyl)bis(N-(2,2,6,6-tetramethylpiperidin-4-yl)formamide).

Effects of donor-acceptor groups on structural and spectroscopic properties of hydrogen-bonded complex of 2-(hydroxymethyl)-1-methyl-piperidine with p-hydroxybenzoic acid and water

The complex of 2-(hydroxymethyl)-1-methyl-piperidine [2-(1-methyl-piperidine)-methanol] (MPMe) and p-hydroxybenzoic acid (HBA) crystallizes as a hydrate. HBA interacts through the OH center dot center dot center dot 0 and NH center dot center dot center dot O hydrogen bonds with MPMe. The water mediated hydrogen-bonded bridge molecules MPMe and HBA. The structure of 2-(hydroxymethyl)-1-methyl-piperidinium p-hydroxybenzoate hydrate has been characterized by X-ray diffraction, FTIR and NMR spectroscopy and optimized at the B3LYP/6-311++G(d, p) level of theory. The potential energy distributions, PED, have been used to assign the vibrational spectra. The GIAO/B3LYP/6-311++G(d,p) calculated magnetic isotropic shielding constants have been used to interpret the chemical shifts in the H-1 and C-13 NMR spectra. (C) 2018 Elsevier B.V. All rights reserved.

If you are hungry for even more, make sure to check my other article about 124172-53-8, Safety of N,N’-(Hexane-1,6-diyl)bis(N-(2,2,6,6-tetramethylpiperidin-4-yl)formamide).

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 124172-53-8, Name is N,N’-(Hexane-1,6-diyl)bis(N-(2,2,6,6-tetramethylpiperidin-4-yl)formamide), formurla is C11H14N2O2. In a document, author is Barton, Benita, introducing its new discovery. SDS of cas: 124172-53-8.

Four xanthenyl-derived compounds: a comparative investigation of their host behaviour in the presence potential saturated and unsaturated heterocyclic six-membered ring guest solvents

Four xanthenyl-derived host compounds, namely trans-N,N ‘-bis(9-phenyl-9-xanthenyl)cyclohexane-1,4-diamine (1,4-DAX), trans-N,N ‘-bis(9-phenyl-9-thioxanthenyl)cyclohexane-1,4-diamine (1,4-DAT), N,N ‘-bis(9-cyclohexyl-9-xanthenyl)ethylenediamine (OED) and N,N ‘-bis(9-cyclohexyl-9-thioxanthenyl)ethylenediamine (SED) were assessed for their selectivity behaviour in the presence of both the saturated and unsaturated heterocyclic six-membered ring guest solvents morpholine (MOR), piperidine (PIP), dioxane (DIO) and pyridine (PYR). Related compounds OED and SED behaved similarly when each was recrystallized from mixtures of these guests, both selecting for MOR and discriminating against PYR, while, surprisingly, the performance of structurally-similar 1,4-DAX and 1,4-DAT in equivalent conditions, on the other hand, was entirely contrasting: only 1,4-DAX formed complexes from such guest mixtures and 1,4-DAT failed to do so in each instance. Furthermore, 1,4-DAX preferred PYR, an observation distinct from that of OED and SED. Single crystal diffraction (SCXRD) experiments were carried out on suitable crystals formed by 1,4-DAX with these guests, and it was revealed that the preference for PYR may be attributed to both host-guest pi-pi interactions and a shorter H-bond between molecules of the host and PYR compared with other complexes. SCXRD experiments were not possible for OED, SED and 1,4-DAT owing to either the inability of the host compound to complex with these guests or poor crystal quality of the resultant complexes.

If you are hungry for even more, make sure to check my other article about 124172-53-8, SDS of cas: 124172-53-8.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem