Tag: M.W:300-400

876379-22-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.876379-22-5,(S)-1-Cbz-3-Boc-Aminopiperidine,as a common compound, the synthetic route is as follows.

TFA (4 ml) was added to a solution of benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate (487 mg, 1.46 mmol) in DCM (6 ml), and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure, and the resultant residue was dissolved in ethyl acetate and a saturated aqueous sodium bicarbonate solution. The separated organic layer was washed with a saturated aqueous sodium chloride solution, and dried over anhydrous sodium sulfate. After the drying agent was removed by filtration, a crude product of benzyl (3S)-3-aminopiperidine-1-carboxylate (501 mg) was obtained as a colorless oily substance by concentration under reduced pressure. LCMS: m/z 235 [M+H]+

The synthetic route of 876379-22-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chugai Seiyaku Kabushiki Kaisha; MURATA, Takeshi; KAWADA, Hatsuo; NIIZUMA, Satoshi; HARA, Sousuke; HADA, Kihito; SHIMADA, Hideaki; TANAKA, Hiroshi; MIO, Toshiyuki; EP2842946; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

769944-78-7, 1-N-Boc-4-(4-Bromophenyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

769944-78-7, A mixture containing 4-(4-bromo-phenyl)-piperidine-1 -carboxylic acid tert-butyl ester (100 mg, 0.29 mmol), 2-tribupsilontylstannanyl-pyrimidi?e (130 mg, 0.36 mmol), cesium fluoride (85 mg, 0.56 mmol) and palladium di-tert-butylphosphine was degassed three times with Ar. Dioxane was added and the formed reaction mixture was stirred at HO 0C overnight under Ar. Then the reaction mixture was filter through celite and the .solvent was removed under vacuum and crude product was used directly in the next step.

The synthetic route of 769944-78-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; WO2007/70398; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

752234-64-3, tert-Butyl 5-methoxy-2-oxospiro[indoline-3,4′-piperidine]-1′-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

752234-64-3, To a solution of the crude product in ethyl acetate (20 ML), a 1 M ethyl acetate solution of HCI (20 ML). After stirring for 2h at room temperature, solvent is evaporated down to. Ethyl ether is added to the residue to give the powder, which is filtrated ; Rf=0.05 (ethyl acetate . ONIY) ; H-NMR (400MHZ, DMSO-DE) J : 1.87-1. 90 (m, 2H), 2.04-2. 11 (m, 2H), 3.24-3. 27 (m, 2H), 3.45-3. 49 (m, 2H), 6.88-6. 89 (m, 1H), 7.00-7. 04 (m, 1H), 7.21-7. 29 (m, 2H), 9.04 (brs, 1H), 10.57 (brs, 1 H).

The synthetic route of 752234-64-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/69256; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1283095-48-6,tert-Butyl 4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate,as a common compound, the synthetic route is as follows.

2,2,6,6-Tetramethylpiperidine (18.7 mL, 1 10.5 mmol) is added overtetrahydrofuran (200 mL), and solution is cooled under nitrogen at -78C. 2.5 M solution of butyl lithium in hexane (37.2 mL, 93 mmol) is added and mixture is stirred for 30 min at -78C. Over the fresh lithium 2,2,6,6-tetramethylpiperidine solution is added a solution of tert-butyl spiro[4,5-dihydrothieno[2,3-c]pyran-7,4′-piperidine]-l’- carboxylate (20 g, 58.2 mmol) in tetrahydrofuran (90 mL) keeping temperature below -70C. After 20 min a solution of N-fluorobenzenesulfonimide (30.26 g, 93.07 mmol) in tetrahydrofuran (200 mL) previously cooled under nitrogen at -20C is added via cannula. After 1 hr. stirring, water (20 mL) and aqueous solution of ammonium chloride (50 mL) are added. Then, organic layer is separated and the aqueous is washed twice with methyl t-butyl ether (2 x 25 mL). Organics are combined and solvent is evaporated under reduced pressure. Crude material is purified by normal phase HPLC using hexane/ methyl t-butyl ether as solvents to give tert-butyl 2- fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4′-piperidine]-r-carboxylate in 50% yield. MS (m/z): 328 (M+l)., 1283095-48-6

1283095-48-6 tert-Butyl 4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate 52951550, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ELI LILLY AND COMPANY; BENITO COLLADO, Ana Belen; DIAZ BUEZO, Nuria; JIMENEZ-AGUADO, Alma Maria; LAFUENTE BLANCO, Celia; MARTINEZ-GRAU, Maria Angeles; PEDREGAL-TERCERO, Concepcion; TOLEDO ESCRIBANO, Miguel Angel; WO2011/60217; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1174020-64-4,tert-Butyl 4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of the product of step 2 (1.455 g, 3.95 mmol; theoretical yield of step 2) in dry pyridine (30 mL) was added sulfur trioxide pyridine complex (3.2 g, 20.11 mmol) at room temperature under nitrogen. The resulting thick mixture was stirred over the weekend.The reaction was filtered and the white insoluble solids were washed well with dichloromethane. The filtrate was concentrated in vacuo. The residue was further azeotroped with toluene to remove excess pyridine to afford the title compound which was used without purification in the next step., 1174020-64-4

As the paragraph descriping shows that 1174020-64-4 is playing an increasingly important role.

Reference£º
Patent; MERCK & CO., INC.; WO2009/91856; (2009); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120014-07-5,2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one,as a common compound, the synthetic route is as follows.

To 200 mL of toluene were added 20 g of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidene]methyl-piperidine and 2 g of 10% palladium-carbon. Hydrogenation was carried out with stirring for 5 hours at 0 to 1 C. and 0.8 to 1.0 MPa. HPLC Purity of the Reaction Solution: the desired compound/72.9%, the starting material/25.3%, the debenzylated product/1.8%.

120014-07-5, As the paragraph descriping shows that 120014-07-5 is playing an increasingly important role.

Reference£º
Patent; Eisai R&D Management Co., Ltd.; US2007/88055; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

883984-95-0, Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

883984-95-0, Step 3: spiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one hydrochloride 16.40 g (0.04 mol) benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3d]-[1,3]oxazine]-1-carboxylate and 2.00 g palladium(Pd/C 10%) in 500 mL EtOH were hydrogenated for 6 h at RT in a hydrogen atmosphere. Then 1 g of palladium (Pd/C 10%) were additionally added and the mixture was hydrogenated for a further 3 h at RT in a hydrogen atmosphere. After filtration of the reaction mixture the solvent was eliminated in vacuo. The residue was triturated with EtOH, the precipitate formed was suction filtered, washed with EtOH and dried in the drying cupboard for 3 h at 50 C.Yield: 5.40 g (50% of theoretical)ESI-MS: m/z=220 (M+H)+ Rt(HPLC): 0.90 min (method C)

The synthetic route of 883984-95-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/149698; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem