Tag: M.W:300-400

160296-40-2, tert-Butyl 4-(4-fluorobenzoyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

60% Sodium hydride (717mg, [18MMOL)] was suspended in anhydrous dimethylformamide [(50ML)] under nitrogen at [5C.] To this was added portion-wise 6-bromo naphthalene-2-thiol (3.89g, 16mmol). The mixture was stirred at [5C] for 30 minutes. 1- (t- [BUTOXYCARBONYL)-4- (4-FLUOROBENZOYL) PIPERIDINE] (Reference Example 12; [5.] 00g 16mmol) was then added to the solution and the reaction heated at [60C] for 16 hours. The solution was poured into water [(75ML)] and washed with EtOAc [(2X75ML).] The organic phases were combined then washed with water then brine. The solution was dried over MgS04, after filtration and evaporation a solid was isolated. This was recrystallised from EtOAc/isohexane resulting in a cream solid (2.96g, 35%). NMR (DMSO-d6) 1.37 (s, [11H),] 1.72 (m, 2H), 2.86 (m, 2H), 3.52 (m, 1H), 3.92 (m, 2H), 7.31 (d, 2H), 7.55 (d, 1H), 7.69 (d, 1H), 7.93 (m, 4H), 8.17 (s, 1H), 8.26 (s, 1H) ; m/z 470., 160296-40-2

The synthetic route of 160296-40-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/33427; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1254058-34-8,3-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline,as a common compound, the synthetic route is as follows.

(5) Under an argon atmosphere, to a mixture of 2-chloro-5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidine (1.03 g), 3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline (1.29 g), 1,1′-binaphthalene-2,2′-diylbis(diphenylphosphine) (609 mg), cesium carbonate (3.19 g), and dioxane (20.6 mL) was added palladium acetate (146 mg) at room temperature, followed by stirring at 100 C. for 4 hours. To the reaction mixture was added water, followed by extraction with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and then filtered. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform/methanol/concentrated aqueous ammonia), purified by basic silica gel columnchromatography (ethyl acetate), and then solidified with ethyl acetate and then with ethanol to obtain 5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine (Compound A: 830 mg). MS (ESI+): 585 [(M+H)+]. NMR (DMSO-d6): 1.45-1.60 (2H, m), 1.73-1.84 (2H, m), 2.14 (3H, s), 2.17-2.58 (11H, m), 3.24-3.36 (2H, m), 3.75 (3H, s), 3.87 (6H, s), 5.16 (2H, s), 6.79 (1H, d, J=8.8 Hz), 7.07 (1H, t, J=8.4 Hz), 7.24 (1H, dd, J=8.8, 2.4 Hz), 7.32 (1H, d, J=2.4 Hz), 8.29 (2H, s), 9.21 (1H, s)., 1254058-34-8

1254058-34-8 3-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline 68014035, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTELLAS PHARMA INC.; FUTAMI, Takashi; TAKESHITA, Rumi; (12 pag.)US2016/199371; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

769944-78-7,769944-78-7, 1-N-Boc-4-(4-Bromophenyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of tert-butyl 4- (4-bromophenyl) piperidine-1-carboxylate (510 mg, 1.499 mmol) , 4, 4, 4′, 4′, 5, 5, 5′, 5′-octamethyl-2, 2′-bi (1, 3, 2-dioxaborolane) (761 mg, 3 mmol) and KOAc (441 mg, 4.5 mmol) in DME (20 ml) was degassed with N2 and PdCl2 (dppf) -CH2Cl2 (122 mg, 0.15 mmol) was added. The resulting mixture was degassed with N2 again and was heated to 80 overnight. After cooling to rt, the mixture was added with 10mL of NH4Cl (aq) , and extracted with EtOAc (20mL ¡Á 2) . The combined organic phase was washed with brine (20mL) , dried over Na2SO4 (anhydrous) , filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (EA/Hexane 0: 100-1: 5) to give the title compound (500 mg , 86) . 1H NMR (400 MHz, CDCl3) delta ppm 1.27 (s, 9H) , 1.34 (s, 12H) , 1.57 -1.72 (m, 2H) , 1.82 (br d, J13.05 Hz, 2H) , 2.66 (br s, 1 H) , 2.80 (br t, J12.05 Hz, 2H) , 4.25 (br d, J12.80 Hz, 2H) , 7.11 -7.42 (m, 2H) , 7.77 (d, J8.03 Hz, 2H) . LC-MS: [M+H-100] + 288.2.

As the paragraph descriping shows that 769944-78-7 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; MOTZ, Gregory; MAVRAKIAS, Konstantinos John; LIU, Jinbiao; LIU, Lei; ZHENG, Qiangang; XUN, Guoliang; XIAO, Qitao; (417 pag.)WO2017/114497; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.287953-54-2,Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

(1) To a solution of Compound 1 (1574 mg) in dichloromethane (10 mL) was added an aqueous solution of dimethylamine (50% aqueous solution, 2 mL) under ice-cooling, and then the mixture was stirred at room temperature for 2 hours. To the reaction mixture were added an aqueous solution of hydrochloric acid (0.5 mol/L) and chloroform, stirred, then the organic layer was separated, washed with saturated saline, dried, and then concentrated under reduced pressure to give Compound 2 (1.609 g) as a colorless viscous material. MS (APCI): m/z 327 [M+H] +

287953-54-2, The synthetic route of 287953-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Mitsubishi Tanabe Pharma Corporation; YAMAMOTO, Yasuo; SATO, Atsushi; MOROKUMA, Kenji; SHITAMA, Hiroaki; ADACHI, Takashi; MIYASHIRO, Masahiko; (260 pag.)EP3150578; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.287953-54-2,Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

(1) To a solution of Compound 1 (1574 mg) in dichloromethane (10 mL) was added an aqueous solution of dimethylamine (50% aqueous solution, 2 mL) under ice-cooling, and then the mixture was stirred at room temperature for 2 hours. To the reaction mixture were added an aqueous solution of hydrochloric acid (0.5 mol/L) and chloroform, stirred, then the organic layer was separated, washed with saturated saline, dried, and then concentrated under reduced pressure to give Compound 2 (1.609 g) as a colorless viscous material. MS (APCI): m/z 327 [M+H] +

287953-54-2, The synthetic route of 287953-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Mitsubishi Tanabe Pharma Corporation; YAMAMOTO, Yasuo; SATO, Atsushi; MOROKUMA, Kenji; SHITAMA, Hiroaki; ADACHI, Takashi; MIYASHIRO, Masahiko; (260 pag.)EP3150578; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.883984-95-0,Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate,as a common compound, the synthetic route is as follows.

INTERMEDIATE 16 r-(Methoxymethvnspirorpiperidine-4.4′-pyrido[2.3-(iiri.31oxazinl-2riy)-one Step A. Benzyl 7′-chloro-l’-(‘methoxymethyl)-2′-oxo-r,2′-dihvdro-lH-spiro[piperidme-4,4’- pyridor2.3-lithium bis(trimethylsilyl)amide (2.86 niL of IM solution, 2.86 mmol) followed by chloromethyl methyl ether (0.094 mL, 1.01 mmol). After 0.5 h, the reaction was diluted with EtOAc, extracted with water (3x) and brine, dried over MgSO4, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel chromatography, eluting with a gradient of 0 to 20% ethyl acetate : dichloromethane to give the title compound (0.21 g). MS 432.1 (M + 1)., 883984-95-0

883984-95-0 Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate 59165781, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK & CO., INC.; WO2006/44504; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1181267-36-6, tert-Butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1181267-36-6, 1) In a three-necked bottle, 100 g of intermediate II was added in sequence, 250 ml of tetrahydrofuran was added, and the reaction was cooled to 0 to 5 C, and 105 ml of concentrated hydrochloric acid was slowly added dropwise, and the mixture was stirred overnight; 2) The liquid phase is controlled to the raw material II <0.5%, and the post-treatment is started; 2) The solvent tetrahydrofuran was evaporated under reduced pressure, and then the mixture was evaporated to dryness. Combine the organic layers. Concentrated under reduced pressure to give the intermediate interrupter III, having a weight of 70.2g, a yield of 96%. The obtained intermediate III was subjected to high performance liquid chromatography analysis, and the spectrum is shown in Fig. 3. There are 5 peaks in the map, and the data is shown in Table 3. The synthetic route of 1181267-36-6 has been constantly updated, and we look forward to future research findings. Reference£º
Patent; Chongqing Huabang Shengkai Pharmaceutical Co., Ltd.; Gao Hongsheng; Wang Haibo; Zhang Yueqin; Fu Yi; Sun Xiaolu; Huang Shanhua; Tang Chaojun; (12 pag.)CN109810093; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1032903-63-1, tert-Butyl 4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 6 (1.0 equiv.) was added to a solution of trisubstituted aniline 49 (5.0 g) in 100 mL CH3CN at room temperature. The resulting reaction mixture was heated to 80C and stirred for 8 h. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The mixture was stirred at 0C for 2 h and filtered. The crude product 7 was used in the next step without further purification. A small sample of 7 was recrystallised to give a brown solid, m.p. 220-221C (CH3CN/MTBE); 1H NMR delta 11.3 (s, 1H), 9.21 (s, 1H), 8.01 (m, 3H), 7.87 (m, 1H), 7.65 (m, 1H), 7.45 (m,1H), 6.73 (s, 1H), 4,59 (m, 1H), 4.28 (m, 2H), 3.27 (m, 1H), 2,79 (m,3H), 2.07 (s, 1H), 1.93 (m, 2H). 1.41-1.75 (m, 25H); 13C NMR delta 154.9,136.5, 134.2, 131.4, 125.8, 79.6, 71.7, 55.0, 38.4, 32.5, 28.5, 22.2, 18.8,15.4; HRMS (m/z) [M+Na]+ calcd for C33H44N6O7SNa 691.2890, found 691.2885., 1032903-63-1

1032903-63-1 tert-Butyl 4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate 59764580, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Haidong; Li, Yuan; Wang, Dongdong; Qin, Yu; Ji, Min; Journal of Chemical Research; vol. 39; 8; (2015); p. 475 – 477;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.301221-79-4,tert-Butyl 4-(2-bromoacetyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

The bromomethylketone prepared as described in Step C (1.48 g, 4.83 mmol) was combined with thioformamide (295 mg, 4.83 mmol) in 10 mL of THF. The reaction mixture was warmed to 60 ¡ãC and stirred for 4 days. The reaction mixture was then diluted with ethyl acetate and washed with water, then brine, dried over anhydrous MgS04, filtered, and concentrated. Purification by MPLC (silica, 60percent ethyl acetate/hexane) afforded 627 mg of thiazole PRODUCT. 1H NMR (400 MHz, CDC13) : 8 8.75 (d, J = 2.0 Hz, 1H), 6.93 (d, J = 2.4 Hz, 1H), 4.19 (br s, 2H), 2.96 (m, 1H), 2.84 (BR M, 2H), 2.03 (m, 2H), 1.62 (m, 2H), 1.44 (s, 9H)., 301221-79-4

As the paragraph descriping shows that 301221-79-4 is playing an increasingly important role.

Reference£º
Patent; MERCK & CO., INC.; WO2004/41279; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

883984-95-0, Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INTERMEDIATE 13 r-Methylspiro[piperidine-4,4′-pyridor2.3-6?[l,31oxazinl-2Yrff)-oneStep A. Benzyl 7′-chloro-r-methyl-2′-oxo-r.2′-dihydro-lH-spiro[piperidine-4,4′-pyrido[2,3- d [1 ,3″|oxazine]-l -carboxylate; To a 0 C solution of benzyl 7′-chloro-2′-oxo-ll,2′-dihydro-lH-spiro[piperidine- 4,4′-pyrido[2,3-<^[l,3]oxazine]-l-carboxylate (0.56 g, 1.43 mmol) in DMF (14 niL) was added lithium bis(trimethylsilyl)amide (2.86 mL of IM solution, 2.86 mmol) followed by methyl iodide (0.11 mL, 2.28 mmol). After Ih, more methyl iodide was added (0.55 mL, 1.14 mmol). After a further Ih, the reaction was diluted with EtOAc, extracted with water (3x) and brine, dried over MgSO4, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel chromatography, eluting with a gradient of 0 to 4% methanol : dichloromethane to give the title compound (0.47 g). MS 402.0 (M + 1). 883984-95-0, The synthetic route of 883984-95-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK & CO., INC.; WO2006/44504; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem