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One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-coupled receptors, and ion channels. An additional aspect of the present invention relates to the use of the novel heterocyclic compounds as analgesics.

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The invention provides a novel substituted alkynyl compound and its pharmaceutically acceptable salt and medicinal preparation, and a use of the novel substituted alkynyl compound and its pharmaceutically acceptable salt and medicinal preparation in adjustment of protein kinase activity and intercellular or intracellular signal response. The invention also relates to a pharmaceutical composition containing the novel substituted alkynyl compound and a method for treating high-proliferative diseases of mammals especially such as human by the pharmaceutical composition.

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Archives for Chemistry Experiments of 2-(2,6-Dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, category: piperidines, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 19171-18-7, Name is 2-(2,6-Dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione, molecular formula is C13H9N3O6. In a Patent, authors is ,once mentioned of 19171-18-7

The present invention provides pyridazine derivatives of formula (I), which are therapeutically useful as SMARCA2/4 degraders. These compounds are useful in the treatment and/or prevention of diseases or disorders dependent upon SMARCA2/4 in a mammal. The present invention also provides preparation of the compounds and pharmaceutical compositions comprising at least one of the pyridazine derivatives of formula (I) or a pharmaceutically acceptable salt, or a stereoisomer thereof.

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Some scientific research about 167484-18-6

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, HPLC of Formula: C20H22N2O2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 167484-18-6, Name is Benzyl spiro[indoline-3,4′-piperidine]-1′-carboxylate, molecular formula is C20H22N2O2. In a Patent, authors is ,once mentioned of 167484-18-6

Disclosed are spiro-substituted azacycles of formula I are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma. In particular compounds of formula I are shown to be neurokinin antagonists.

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Compounds of general formula (I): or a stereoisomer, tautomer, polymorph, hydrate, solvate, or a pharmaceutically acceptable salt thereof, wherein R is as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as proliferative diseases, e.g. cancers, viral and fungal infections, neurodegenerative or inflammatory diseases or conditions. The invention also relates to the preparation of these compounds as well as to pharmaceutical compositions comprising them.

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Awesome and Easy Science Experiments about 1-Boc-4-(Tosyloxy)piperidine

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The present review focuses on strategies for the construction of piperidines which have appeared in the literature since 2003 through mid-2017. In a preceding chapter (2017AHC191), we summarized synthetic methods involving the construction of the piperidine ring from essentially acyclic starting materials in an intra- or intermolecular manner. The present chapter aims at giving a general overview of decoration or modification of previously generated pyridines or piperidines. The hydrogenation of preformed pyridine or pyridinium rings and introduction of substituents into fully saturated piperidines as well as ring expansion of pyrrolidines to piperidines are the most prevalent methods.

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Properties and Exciting Facts About tert-Butyl 4-iodopiperidine-1-carboxylate

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New compounds are disclosed which have utility in the treatment of a variety of metabolic related conditions in a patient. The compounds of this invention have the structure (I): wherein R1, R2, R3, n, p, q, and Ar are as defined herein, including stereoisomers, solvates and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising a compound of this invention, as well as methods relating to the use thereof in a patient in need thereof.

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Extracurricular laboratory:new discovery of tert-Butyl 4-iodopiperidine-1-carboxylate

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The present invention provides a process for preparing benzimidazole thiophene compounds of formula I. Intermediates used in the process are also claimed.

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A new application about 145508-94-7

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Application of 145508-94-7, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 145508-94-7, Name is tert-Butyl 4-(iodomethyl)piperidine-1-carboxylate, molecular formula is C11H20INO2. In a Article,once mentioned of 145508-94-7

The development of a novel, efficient and robust method for the general conversion of aliphatic and aromatic carboxylic acids to organic iodides without the use of heavy metals or strong oxidizing agents is reported. Commercially available N-iodoamides were used for both initiation and halogen donation under irradiative conditions. Isolation of the product is extremely simple and the major co-product is removed as a water-soluble biodegradable material. Copyright

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Top Picks: new discover of 1-Boc-4-(4-Iodo-1H-pyrazol-1-yl)piperidine

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The present invention provides compounds of Formula (II) for the treatment of cancer, rheumatoid arthritis and other diseases.

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