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Abstract A modified Pd-catalyzed method of forming aryl- and heteroarylboron species and a two-step, one-pot borylation/Suzuki-Miyaura cross coupling using the atom economical tetrahydroxydiboron (bis-boronic acid, BBA) is reported. By using ethylene glycol as an additive, the new method results in increased yields, lower BBA loading, faster reaction times, and a broader reaction scope, including previously problematic substrates such as heterocycles.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H22183N – PubChem

 

17-Sep-2021 News Brief introduction of 135716-09-5

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Compounds, pharmaceuticals, kits, and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: wherein Q is selected from the group of CO, SO, SO 2, or C=NR 9; and R1, R2, R3 and R4 are as defined herein.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H21967N – PubChem

 

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The present invention relates to compounds useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H22372N – PubChem

 

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Rhodium(iii)-catalyzed mild benzylic alpha-fluoroalkenylation of 8-methylquinolines with gem-difluorostyrenes has been developed. This reaction occurred via C-H activation and C-F cleavage and is applicable to a wide range of substrates, leading to the synthesis of Z-alkenyl fluorides under mild and redox-neutral conditions with high regio- and stereoselectivity.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H17563N – PubChem

 

Sep 2021 News Simple exploration of 166953-64-6

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A selective Iron-catalyzed cross-coupling of alkyl halldes with alkenylzinc reagents Is described. Primary and secondary alkyl chlorides, bromides, and iodides take part In the reaction to give the corresponding olefins In good to excellent yields In a stereospecific manner. High functional group compatibility Is also demonstrated by using combinations of substrates possessing rather reactive substituents.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H23004N – PubChem

 

Sep 2021 News Extracurricular laboratory:new discovery of 205059-24-1

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Reference of 205059-24-1, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 205059-24-1, Name is tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylate, molecular formula is C14H27N3O2. In a Patent,once mentioned of 205059-24-1

The present invention relates to novel substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-related disorders.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H21771N – PubChem

 

17/9/2021 News New explortion of 92235-39-7

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Product Details of 92235-39-7, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 92235-39-7, Name is (S)-tert-Butyl (2-oxopiperidin-3-yl)carbamate, molecular formula is C10H18N2O3. In a Article, authors is Hamilton, Deborah J.,once mentioned of 92235-39-7

A simple and efficient synthesis of L-arginine has been achieved in 12 steps and 24% overall yield. Regioselective reduction and functional group manipulation of the beta-side chain of aspartic acid allowed the preparation of an ornithine derivative, which was then guanylated with a bis-protected 1-guanyl-pyrazole and deprotected to give L-arginine. This approach allows the flexible incorporation of stable isotopes and this is demonstrated using potassium 13C-cyanide, which has resulted in the preparation of 5-13C-L-arginine.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H16635N – PubChem

 

17/9/2021 News The Absolute Best Science Experiment for 138163-08-3

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent, HPLC of Formula: C14H17NO3, Which mentioned a new discovery about 138163-08-3

The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H20521N – PubChem

 

17/9/2021 News Extracurricular laboratory:new discovery of 138163-08-3

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 138163-08-3, name is Benzyl 4-formylpiperidine-1-carboxylate, introducing its new discovery. category: piperidines

Alkyne compounds of formula I wherein A, B, W, X, Y, Z, R1, and R2 have the meanings given herein, which have MCH-receptor antagonistic activity and are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H20600N – PubChem

 

17-Sep News Awesome and Easy Science Experiments about 352673-16-6

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A series of caspase inhibitors containing gamma-amino acid moiety have been synthesized. A systemic study on their structure-activity relationship of anti-apoptotic cellular activity is presented. These efforts led to the discovery of compound 20o as a potent caspase inhibitor, which demonstrated preclinical ameliorating total bilirubin efficacy with a significantly improved pharmacokinetic profile.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H21688N – PubChem