Tag: M.W:200-300

Application of 600-05-5. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,3-Dibromopropionic acid, is researched, Molecular C3H4Br2O2, CAS is 600-05-5, about Synthesis of (α-T)polyacrylic acid. Author is Postolache, Cristian; Matei, Lidia.

A polyacrylic acid (PAA) hydrogel with biotechnol., medical and pharmaceutical applications was synthesized by radiopolymn. of acrylic acid (AA) aqueous solutions Due to its high capacity for water absorption, the PAA hydrogel may be a good alternative for storage of low or medium-activity tritium liquid wastes. The stability towards radiolysis of PAA:H2O and self-radiolysis of PAA:HTO hydrogel was analyzed. The labeled PAA was obtained in two main steps. In the first step, the sodium [2-T]acrylate monomer was obtained by catalytic hydrogenation of 2-bromoacrylic acid. In the second step, the hydrogel was produced by radiopolymn. of the labeled monomer.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Application In Synthesis of 1-Boc-4-(Aminomethyl)piperidine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Boc-4-(Aminomethyl)piperidine, is researched, Molecular C11H22N2O2, CAS is 144222-22-0, about Discovery of novel tetrahydrobenzo[b]thiophene-3-carbonitriles as histone deacetylase inhibitors. Author is Gediya, Piyush; Vyas, Vivek K.; Carafa, Vincenzo; Sitwala, Nikum; Della Torre, Laura; Poziello, Angelita; Kurohara, Takashi; Suzuki, Takayoshi; Sanna, Vinod; Raguraman, Varalakshmi; Suthindhiran, K.; Ghosh, Debarpan; Bhatia, Dhiraj; Altucci, Lucia; Ghate, Manjunath D..

The discovery and development of isoform-selective histone deacetylase (HDAC) inhibitor is a challenging task because of the sequence homol. among HDAC enzymes. In the present work, novel tetrahydro benzo[b]thiophene-3-carbonitrile based benzamides were designed, synthesized, and evaluated as HDAC inhibitors. Pharmacophore modeling was the main design strategy, and two novel series of tetrahydro benzo[b]thiophene-3-carbonitrile derivatives with piperidine linker (series 1) and piperazine linker (series 2) were identified as HDAC inhibitors. Among all the synthesized compounds, I with 4-(aminomethyl) piperidine linker and II with piperazine linker demonstrated good activity against human HDAC1 and HDAC6, resp. Both the compounds also exhibited good antiproliferative activity against several human cancer cell lines. Both these compounds (I and II) also induced cell cycle arrest and apoptosis in U937 and MDA-MB-231 cancer cells. Overall, for the first time, this research discovered potent isoform-selective HDAC inhibitors using cyclic linker instead of the aliphatic chain and aromatic ring system, which were reported in known HDAC inhibitors.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, ACS Chemical Neuroscience called Discovery and SAR Studies of Orally Active Somatostatin Receptor Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly, Author is Ishida, Akiharu; Tajima, Yohei; Okabe, Yasuyuki; Matsushita, Takeshi; Sekiguchi, Tetsuya; Imaide, Satomi; Nomura, Yoshinori; Tanaka, Motoyuki; Nojima, Shoji; Yoshida, Atsushi; Iyoda, Yoko; Aoki, Shohei; Nishio, Takuya; Komagata, Tatsuya; Iwaki, Masanori; Shono, Tomoyuki; Naganawa, Atsushi; Imagawa, Akira, which mentions a compound: 144222-22-0, SMILESS is NCC1CCN(C(OC(C)(C)C)=O)CC1, Molecular C11H22N2O2, COA of Formula: C11H22N2O2.

Acromegaly is a disease caused by the oversecretion of growth hormone. It is currently treated by i.v. injection with cyclic peptide drugs that activate somatostatin receptor subtype 2 (SSTR2). Here, novel nonpeptidic, small-mol., and orally active SSTR2 agonists were identified from a hit compound (13). Pharmacophore studies enabled scaffold hopping to obtain a unique 3,4,5-trisubstituted pyridine motif. Further optimization conferred potent SSTR2 agonistic activity and metabolic stability. Several compounds were evaluated and these showed good oral pharmacokinetic profiles in rats, and one representative compound (25)(I) showed highly potent inhibition of growth hormone secretion induced by growth hormone-releasing hormone in rats. Based on these results, 25 was identified as a promising lead for further optimization. A structure-activity relationship (SAR) study and the metabolic stability data for this compound are also described.

In addition to the literature in the link below, there is a lot of literature about this compound(1-Boc-4-(Aminomethyl)piperidine)COA of Formula: C11H22N2O2, illustrating the importance and wide applicability of this compound(144222-22-0).

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Maeder, Patrick; Bartholomaeus, Ruben; Nicolussi, Simon; Baumann, Alice; Weis, Melanie; Chicca, Andrea; Rau, Mark; Simao, Ana Catarina; Gertsch, Juerg; Altmann, Karl-Heinz researched the compound: 1-Boc-4-(Aminomethyl)piperidine( cas:144222-22-0 ).Reference of 1-Boc-4-(Aminomethyl)piperidine.They published the article 《Synthesis and Biological Evaluation of Endocannabinoid Uptake Inhibitors Derived from WOBE437》 about this compound( cas:144222-22-0 ) in ChemMedChem. Keywords: synthesis biol evaluation endocannabinoid uptake inhibitor WOBE437 derivative; WOBE437; anandamide transport inhibitor; endocannabinoid membrane transport; endocannabinoid system; structure-activity relationship. We’ll tell you more about this compound (cas:144222-22-0).

WOBE437 ((2E,4E)-N-(3,4-dimethoxyphenethyl)dodeca-2,4-dienamide, I) is a natural product-derived, highly potent inhibitor of endocannabinoid reuptake. In this study, we synthesized almost 80 analogs of I with different types of modifications in the dodecadienoyl domain as well as the dimethoxyphenylethyl head group, and we investigated their effects on anandamide uptake into U937 cells. Intriguingly, none of these analogs was a more potent inhibitor of anandamide uptake than WOBE437. At the same time, a number of WOBE437 variants exhibited potencies in the sub-100 nM range, with high selectivity over inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase; two compounds were virtually equipotent with I. Interestingly, profound activity differences were observed between analogs in which either of the two methoxy substituents in the head group had been replaced by the same bulkier alkoxy group. Some of the compounds described here could be interesting departure points for the development of potent endocannabinoid uptake inhibitors with more drug-like properties.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Recommanded Product: 2,3-Dibromopropionic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2,3-Dibromopropionic acid, is researched, Molecular C3H4Br2O2, CAS is 600-05-5, about Combining high resolution mass spectrometry with a halogen extraction code to characterize and identify brominated disinfection byproducts formed during ozonation. Author is Lu, Yao; Song, Zhi-Min; Wang, Chao; Liang, Jun-Kun; Hu, Qing; Wu, Qian-Yuan.

Ozonation is widely used during water treatment but can generate a variety of toxic disinfection byproducts, especially in the presence of bromide. In the present study, our halogen extraction code was extended and modified to identify bromine isotopic patterns and combined with the R package MFAssignR in selectively identifying brominated disinfection byproducts (Br-DBPs) from high resolution mass spectra. In total, 127 Br-DBPs formed from a Suwannee River natural organic matter (SRNOM) solution were successfully detected from tens of thousands of mass spectrometry peaks. Kendrick mass defect anal. and structural characterization identified 17 structures, 15 of which were identified as brominated carboxylic acids and firstly reported here. Computational model predictions indicated that these brominated carboxylic acids may possess high toxic potencies and raise valid concerns. The adapted halogen extraction code described in this study is a powerful tool for a wider application of analyzing Br-DBPs in complex water matrixes and provides an effective technique to characterize and identify these compounds in future studies.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Boc-4-(Aminomethyl)piperidine(SMILESS: NCC1CCN(C(OC(C)(C)C)=O)CC1,cas:144222-22-0) is researched.Recommanded Product: 2,3-Dibromopropionic acid. The article 《NIR-Light-Activated Combination Therapy with a Precise Ratio of Photosensitizer and Prodrug Using a Host-Guest Strategy》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:144222-22-0).

The co-delivery of photosensitizers with prodrugs sensitive to reactive oxygen species (ROS) for light-triggered ROS generation and cascaded prodrug activation has drawn tremendous attention. However, the absence of a feasible method to deliver the two components at a precise ratio has impaired the application potential. Herein, we report an efficient method to produce a nanosized platform for the delivery of an optimized ratio of the two components by the means of host-guest strategy for maximizing the combination therapy efficacy of cancer treatment. The key features of this host-guest strategy for the combination therapy are that the ratio between photosensitizer and ROS-sensitive prodrug can be easily tuned, near-IR (NIR) irradiation can sensitize the photosensitizer and activate the paclitaxel prodrug for its release, and the accumulation process can be tracked by NIR imaging to maximize the efficacy of photodynamic and chemotherapy.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Separation of halogenated acetic and propionic acids by paper chromatography》. Authors are Chittum, John W.; Gustin, Thomas A.; McGuire, Robert L.; Sweeney, John T..The article about the compound:2,3-Dibromopropionic acidcas:600-05-5,SMILESS:O=C(O)C(Br)CBr).Computed Properties of C3H4Br2O2. Through the article, more information about this compound (cas:600-05-5) is conveyed.

cf. C.A. 46, 889i. Mixtures containing (1) AcOH, ClCH2CO2H, Cl2CHCO2H, and Cl3CCO2H and (2) AcOH, BrCH2CO2H, Br2CHCO2H, and Br3CCO2H were separated by the method of Reid and Lederer (C.A. 46, 1923a). Rf values are given for the above acids and certain halogenated propionic acids.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Boc-4-(Aminomethyl)piperidine, is researched, Molecular C11H22N2O2, CAS is 144222-22-0, about Ni-catalyzed hydroalkylation of olefins with N-sulfonyl amines.Product Details of 144222-22-0.

Herein, a reliable method for accessing α-branched amines RNHCH(R1)(CH2)2R2 (R = (4-methylphenyl)sulfonyl, (2,4,6-trimethylphenyl)sulfonyl; R1 = Ph, 4-morpholinophenyl, furan-2-yl, etc.; R2 = Ph, 3-fluorophenyl, 9H-fluoren-2-yl, etc.) via nickel-catalyzed hydroalkylation reactions was reported. Specifically, by using bis(cyclooctadiene)nickel (Ni(cod)2) together with a phosphine ligand, a formal C(sp3)-H bond insertion reaction between olefins CH2=CHR2 and N-sulfonyl amines RNHCH2R1 without the need for an external hydride source was achieved. The amine not only provides the alkyl motif but also delivers hydride to the olefin by means of a nickel-engaged β-hydride elimination/reductive elimination process. This method provides a platform for constructing chiral α-branched amines (R/S)-RNHCH(R1)CH2CH2R2 by using a P-chiral ligand, demonstrating its potential utility in organic synthesis. Notably, a sulfonamidyl boronate complex formed in situ under basic conditions promotes ring-opening of the azanickellacycle reaction intermediate, leading to a significant improvement of the catalytic efficiency.

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Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Safety of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate, is researched, Molecular C11H21NO3, CAS is 145166-06-9, about Study of stereomeric peptoid chiral stationary phases containing different chiral side chains. Author is Wu, Haibo; Song, Guangjun; Wang, Dongqiang; Yu, Hui; Ke, Yanxiong; Liang, Xinmiao.

The authors studied six stereomeric peptoid chiral stationary phases (CSPs) successively combining N’-phenyl-proline amide, α-phenylethyl amine, 2-aminocyclohexyl phenylcarbamate and another α-phenylethyl amine under normal phase mode. CSPs 1-4, I, with R-S-(1R,2R)-S, R-S-(1S,2S)-S, R-R-(1R,2R)-R and R-R-(1S,2S)-R configuration exhibited much different enantiorecognition abilities. Overall, CSPs 1 and 2 performed better for the 55 analytes tested. CSP 5 (I, R-S-rac-S) with mixed selectors combined partial selectivities of CSPs 1 and 2. CSP 6 (I, S-R-(1R,2R)-R) as enantiomeric counterpart of CSP 2 exhibited similar enantioseparation ability and reversal elution orders for analytes resolved. For several biaryl type analytes, CSP 6 even outperformed com. Chiralpak AD-H and Chiralcel OD-H. Excellent resolution of 3,3′-diphenyl-2,2′-bi-1-naphthalol (VANOL) on CSP 6 illustrated its potential application in preparative enantioseparation Eluting orders of enantiomers on stereomeric CSPs also provided the authors further insight into enantiorecognition of some analytes.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Journal of Magnetic Resonance called Conditional rotations of heteronuclear coupled spins, Author is O’Donnell, Lauren F.; Ridge, Clark D.; Walls, Jamie D., which mentions a compound: 600-05-5, SMILESS is O=C(O)C(Br)CBr, Molecular C3H4Br2O2, Related Products of 600-05-5.

The authors present a new pulse sequence that conditionally excites I spin magnetization only in the presence of a nonzero heteronuclear coupling to an S spin. The pulse sequence, referred to as the reverse INEPT pathway selective pulse or RIPSP, generates a pure I spin rotation by an angle that depends upon the heteronuclear coupling constant in InS spin systems. Exptl. demonstrations are shown in 13C labeled chloroform, dichloromethane, and toluene samples and in unlabeled 2,3-dibromopropionic acid and brucine samples.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem