Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122860-33-7,Benzyl 4-(hydroxymethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Reaction Step 2 Synthesis of benzyl 4-formylpiperidine-1-carboxylate To a stirred solution of benzyl 4-(hydroxymethyl)piperidine-1-carboxylate (10.0 g, 40.2 mmol, 1.0 eq) in dichloromethane (150 ml), Dess-Martin periodinane (20.4 g, 48.2 mmol, 1.2 eq) was added at 0 C. and stirring was continued at room temperature for 12 h. After completion of the reaction (monitored by TLC, 30% ethyl acetate-hexane, Rf=0.45), the mixture was diluted with dichloromethane and washed with saturated sodium bicarbonate solution, followed by brine. The organic extract was dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel (100-200 mesh), eluting with a 30-40% gradient of ethyl acetate in hexanes to obtain benzyl 4-formylpiperidine-1-carboxylate (6.2 g, 62.5%). LCMS Purity: 78.54% (ES+): m/z 248.27 (M+H+); tr=3.01 min., 122860-33-7

122860-33-7 Benzyl 4-(hydroxymethyl)piperidine-1-carboxylate 736490, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; INNOV17 LLC; Gaweco, Anderson; Tilley, Jefferson; Blinn, James; (68 pag.)US2016/24056; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

189321-63-9, 1-Boc-4-Methylpiperidine-4-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. Preparation of 4-methylpiperidine 4-carboxylic acid. 1-(tert-Butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid (0.500 g, 2.06 mmol) was treated with 4 M HCl in dioxane (10 mL) for 2 hours at room temperature to afford the title compound (0.294 g, 100%) as the hydrochloride salt. MS (ES+) [M+H]+=144.0., 189321-63-9

As the paragraph descriping shows that 189321-63-9 is playing an increasingly important role.

Reference：
Patent; Burgoon, Hugh Alfred; Goodwin, Nicole Cathleen; Harrison, Bryce Alden; Healy, Jason Patrick; Liu, Ying; Mabon, Ross; Marinelli, Brett; Rawlins, David Brent; Rice, Dennis Stewart; Whitlock, Norris Andrew; US2009/264450; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

236406-22-7, 1-Boc-4-(Aminomethyl)-4-methylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 6. Synthesis of 4-benzyloxycarbonylaminomethyl-1-{(2R)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-phenylacetyl}-4-methylpiperidine The title compound was prepared by a method similar to Step 3 for Example 1, using 4-benzyloxycarbonylaminomethyl-4-methylpiperidine.

236406-22-7, As the paragraph descriping shows that 236406-22-7 is playing an increasingly important role.

Reference：
Patent; Banyu Pharmaceutical Co Ltd; US6140333; (2000); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118133-15-6,1-(Ethoxycarbonyl)piperidine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

In dichloromethane (2 mL) solution of 1-(ethoxycarbonyl)piperidine-4-carboxylic acid (17 mg, 0.0766×1.1 mmol) under ice-cooling, and argon gas atmosphere. 1-ethyl-(3-dimethylaminopropyl)-carbodiimide hydrochloride (16 mg, 0.0766×1.1 mmol) and 1-hydroxybenzotriazol monohydrate (13 mg, 0.0766×1.1 mmol) were added and stirred for 30 minutes. Subsequently, 4-chloro deacetyl colchicine (30 mg, 0.0766 mmol) was added, and stirred overnight, temperature is increased to room temperature gradually. Reaction mixture was purified by flash chromatography (equipment: Biotage Isolera One, and chloroform/methanol), to obtain title compound (an opalescence solid, 41 mg, 0.0714 mmol, 93%) .

118133-15-6, The synthetic route of 118133-15-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; CHIBA UNIVERSITY; YAKULTHONSHA COMPANY LIMITED; TAKAYAMA, HIROMITSU; YASOBU, NAOKO; KITAJIMA, MARIKO; YAEGASHI, TAKASHI; MATSUZAKI, TAKESHI; NAGAOKA, MASATO; HASHIMOTO, SHUSUKE; NISHIYAMA, HIROYUKI; SUGIMOTO, TAKUYA; ONO, MASAHIRO; (176 pag.)JP5829520; (2015); B2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

141774-61-0, tert-Butyl (piperidin-2-ylmethyl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A reaction flask charged with capsaicin (1 eq) and ethyl acetate, cooled to 0 – 10 C, and then DIPEA (3 eq) was added followed by the addition of nitrophenylchloroformate (1.0 eq) as a solution in ethyl acetate at 0 – 10 C. The resulting mixture was stirred at 0 – 10 C for 15 min. Next, HOBt (0.1 eq) was added, followed by A-1 free base (1.2 eq) at 0 – 10 C. The resulting mixture was stirred overnight after warming to room temperature. The reaction mixture was worked up by successive extractions with IM aq. NaOH (3x), IM aq. HCl, water and finally brine solution. The resulting organic layer was removed, dried over sodium sulfate and filtered to afford A-2 in an ethyl acetate solution. The crude product was used in the following reaction without further manipulation., 141774-61-0

The synthetic route of 141774-61-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; CONCENTRIC ANALGESICS, INC.; DONOVAN, John F.; HUSFELD, Craig; (120 pag.)WO2018/217937; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.140645-24-5,(S)-3-(Aminomethyl)-1-N-Boc-piperidine,as a common compound, the synthetic route is as follows.

Example 6: Preparation of (S)-fert-butyl 3-((2-((Z)-(2,6-dimethylphenylimino)-((?)-2-(4- (l-(4-(trifluoromethoxy)phenyl)-lH-l,2,4-triazol-3-yl)benzylidene)hydrazinyl)- methylthio)acetamido)methyl)piperidine-l-carboxylate (Compound 56C) (Synthesis Method E)To a solution of bromoacetyl bromide (26 microliters (mu), 0.299 mmol) in dichloroethane (3 mL) was added dropwise a solution of (5)-i140645-24-5

The synthetic route of 140645-24-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; DOW AGROSCIENCES LLC; CROUSE, Gary D.; SPARKS, Thomas C.; DENT, William Hunter; MCLEOD, CaSandra Lee; CREEMER, Lawrence C.; WO2012/109125; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

24686-78-0, 1-Benzoylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

24686-78-0, Example 95 Synthesis of 4-[(1-benzoylpiperidin-4-yl)amino]-2-methoxybenzamide To a solution of the 4-amino-2-methoxybenzamide obtained in Example 74 (b) or Example 86 (a) (150 mg, 0.902 mmol) in methanol (7.5 ml) were added 1-benzoyl-4-piperidone (183 mg, 0.902 mmol) and acetic acid (0.052 ml, 0.90 mmol), and the resulting mixture was stirred at room temperature for 30 minutes. Then, acetic acid (0.103 ml, 1.80 mmol) and sodium cyanoborohydride (130 mg, 2.06 mmol) were added thereto, followed by stirring at room temperature for 31 hours. During this stirring, 1-benzoyl-4-piperidone (183 mg, 0.902 mmol), sodium cyanoborohydride (208 mg, 3.30 mmol) and acetic acid (0.154 ml, 2.70 mmol) were further added thereto. The reaction mixture was poured into a 1N-aqueous sodium hydroxide solution and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and the resulting residue was purified by a silica gel column chromatography (eluent: ethyl acetate/methanol = 100/1 to 50/1) to obtain 4-[(1-benzoylpiperidin-4-yl)amino]-2-methoxybenzamide (97 mg, 30percent). IR (neat): 3455, 3309, 2939, 1604, 1573, 14 23, 1338, 1211cm-1.

As the paragraph descriping shows that 24686-78-0 is playing an increasingly important role.

Reference：
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1500643; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

180307-56-6, tert-Butyl 4-vinylpiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(x) 4-{2-[3-(1-tert-Butoxycarbonylmethyl-piperidin-4-yl)-1-(4-fluoro-benzyl)-1H-indazol-6-yl]-(E)-vinyl}-piperidine-1-carboxylic acid tert-butyl ester A stirred mixture of {4-[6-bromo-1-(4-fluoro-benzyl)-1H-indazol-3-yl]-piperidin-1-yl}-acetic acid tert-butyl ester (286 mg, 0.57 mmol), 4-vinyl-piperidine-1-carboxylic acid tert-butyl ester (120 mg, 0.57 mmol), lithium chloride (24 mg, 0.57 mmol), triethylamine (0.24 ml, 1.71 mmol), palladium (II) acetate (8 mg 0.03 mmol), tri-o-tolylphosphine (35 mg, 0.11 mmol), and DMF (5 ml) was heated at 105 (oil-bath temperature) under nitrogen for 18 h. When cool, the mixture was evaporated in vacuo, treated with aqueous saturated sodium bicarbonate (20 ml), and extracted with ethyl acetate (2*20 ml). The combined, dried (Na2 SO4) organic extracts were evaporated, and the residue purified by flash chromatography over silica gel (Merck 9385). Elution with ethyl acetate –cyclohexane (1:2) afforded impure fractions and pure fractions (I). The impure fractions were purified by flash chromatography over silica gel (Merck-9385) eluding with ethyl acetate–cyclohexane (gradient 1:4 to 1:2) to give pure fractions (II). The pure fractions (I) and (II) were combined to give the title compound as a pale yellow oil (195 mg).

180307-56-6, The synthetic route of 180307-56-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Glaxo Group Limited; US5861414; (1999); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

61995-20-8, Benzyl 3-oxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

61995-20-8, General procedure: The reaction mixture containing 200 mM substrate, 1mM NAD+, 5% (v/v) 2-propanol and 10mg crude enzyme READH in 1mL potassium phosphate buffer (100mM, pH 7.0) was incubated at 50 C. For ChKRED20, 40% (v/v) 2-propanol and a reaction temperature of 40 C were applied instead. The reaction was monitored by TLC, and terminated by extracting with methyl tert-butyl ether (1 mL). The organic extract was dried over anhydrous sodium sulfate and concentrated. The samples were subjected to chiral HPLC to determine the conversion and enantiomeric excess. The products were purified by silica gel column chromatography, and identified by NMR analysis, optical rotation measurements and mass spectrometry.

61995-20-8 Benzyl 3-oxopiperidine-1-carboxylate 1514169, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Li, Chao; Liu, Yan; Pei, Xiao-Qiong; Wu, Zhong-Liu; Process Biochemistry; vol. 56; (2017); p. 90 – 97;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7006-50-0,4-(Methylamino)-1-benzylpiperidine,as a common compound, the synthetic route is as follows.,7006-50-0

Preparation 21; N-(1-Benzy(piperidin-4-yl)-N-methyipyridin-2-amine A mixture of 4-methylamino-1-benzylpiperidine; [(1.5g, 6.2mmol), J. Med. Chem. 39, 3769-89; 1996] 1-bromopyridine (0.98g, 6.2mmol), sodium tert-butoxide (0.68g, 7.3mmol), 1,3-bis(diphenylphosphino)propane (102mg, 0.24mmol) and tris (dibenzylideneacetone)dipalladium(O) (113mg, 0.12mmol) in toluene (20mL) was heated under reflux for 4 hours. Tlc analysis showed that there was still starting material present and so further bromopyridine (0.49g, 3.1 mmol), tris (dibenzylideneacetone)dipalladium(0) (113mg, 0.12mmol), bis(diphenylphosphino)propane (102mg, 0.24mmol) and sodium tert-butoxide (0.68g, 7.3mmol) were added and heating continued for a further 3 hours. The mixture was then diluted with dichloromethane and washed with brine. The organic solution was dried over magnesium sulfate and concentrated in vacuo and the residue was purified by column chromatography on silica gel, eluting with dichloromethane: methanol: 0. 88 ammonia, 90: 10:1 to afford the title compound in 40% yield, 0.69g.

7006-50-0 4-(Methylamino)-1-benzylpiperidine 4136128, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/105779; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem