Tag: M.W:200-300

189333-49-1,189333-49-1, 3-Benzyl-3,9-diazaspiro[5.5]undecane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-benzyl-3,9-diazaspiro[5.5]undecane (3.3 mmol) in anhydrous DMSO (5 mL) is added 4-fluoro-N-methylbezamide (3.9 mmol) and potassium carbonate (3.9 mmol). The resulting mixture is heated at 140 C. for 2 days. The reaction mixture is allowed to cool to rt, poured into cold water (10 mL), and extracted with EA (10 mL×3). The combined organic layers are washed with water and brine, dried over sodium sulfate, and concentrated. The crude product is purified through PTLC (4% TEA in EA) to give the title compound as a white solid.

The synthetic route of 189333-49-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Xu, Yuelian; Caldwell, Timothy M.; Xie, Linghong; Chenard, Bertrand L.; US2008/247964; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

914988-10-6,914988-10-6, tert-Butyl 3-cyano-4-oxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tert-butyl 3-cyano-4-oxopiperidine-1-carboxylate (13.6 g, 61 mmol) in 50 mL of dry toluene was added 2-(4-phenoxyphenylamino)acetonitrile (11.38 g, 51 mmol), followed by 4-methylbenzenesulfonic acid (1.36 g, 6.1 mmol). The resulting mixture was heated to reflux with a Dean-Stark for 5 h. After cooling down to RT, the mixture was washed with 50 mL of sat. NaHCO3 solution. The organic phase was collected, the aqueous phase was further extracted with EA (30 mL×3). The combined organic phases were dried over Na2SO4, filtered and concentrated under reduced pressure. The crude residue was purified by chromatograph on 300 g of silica gel (eluting with EA/PE=from to ) to give 7.3 g (27.8%) of the desired compound as a gray solid. 1H NMR (400 MHz, DMSO-d6) delta 7.41-7.34 (m, 2H), 7.28-7.23 (m, 2H), 7.16-7.10 (m, 1H), 7.10-7.05 (m, 2H), 7.04-6.99 (m, 2H), 4.86 (s, 2H), 3.97 (s, 2H), 3.50 (t, J=5.6 Hz, 2H), 2.44 (t, J=5.6 Hz, 2H), 1.42 (s, 9H). MS (ESI) m/e [M+23]+ 430.9

914988-10-6 tert-Butyl 3-cyano-4-oxopiperidine-1-carboxylate 42609283, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Wang, Zhiwei; Guo, Yunhang; US2015/5277; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

936130-82-4, Methyl 4-(piperidin-4-yl)benzoate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of X (100 mg, 0.332 mmol), 124-0 (115 mg, 0.450 mmol), and Et3N (75 mu,, 0.54 mmol) in MeOH (5.0 mL) is stirred at ambient temperature for 15 min. The mixture is treated with NaCNBH3 (35.0 mg, 0.550 mmol) and acetic acid (2 drops), and stirred for 16 h. The reaction mixture was concentrated and the resultant residue is purified by flash chromatography (0-10% NH3 in MeOH in DCM) to give 124-1., 936130-82-4

As the paragraph descriping shows that 936130-82-4 is playing an increasingly important role.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ABEYWARDANE, Asitha; BRUNETTE, Steven Richard; BURKE, Michael Jason; KIRRANE, Thomas Martin, Jr.; MAN, Chuk Chui; MARSHALL, Daniel Richard; PADYANA, Anil Kumar; RAZAVI, Hossein; SIBLEY, Robert; SMITH KEENAN, Lana Louise; SNOW, Roger John; SORCEK, Ronald John; TAKAHASHI, Hidenori; TAYLOR, Steven John; TURNER, Michael Robert; YOUNG, Erick Richard Roush; ZHANG, Qiang; ZHANG, Yunlong; ZINDELL, Renee M.; WO2014/14874; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10315-06-7,Methyl 1-benzylpiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

Synthesis of the intermediate compound 6 was carried out according to the previously reported procedure [37] . n-Butyllitium solution (19 mL, 1.6 M in hexane) was added to 6.8 g of 4-bromobenzotrifluride 2 (30 mmol) in diethyl ether. To this mixture 2.4 g (10 mmol) of methyl-1-benzylpiperidine-4-carboxylate 1 were added dropwise at 5 C. The reaction mixture was stirred at room temperature for 1 h and at 45 C for 2 h. The crude product was obtained according to the reported procedures, and purified by silica gel flash column chromatography using 0-50% ethyl acetate/hexane as eluent to yield a brown solid. (4.4 g, 77% yield). 1H NMR (CDCl3): delta 7.64 (m, 8H, 2 * trifluromethylphenyl ArH), 7.33-7.30 (m, 5H, Benzyl ArH) 3.56 (s, 2H, Benzylic CH2), 3.00-2.97 (m, 2H, N-CH2-CH2), 2.54 (t, J = 11.6 Hz, 1H, N-CH2-CH2-CH), 2.10-2.07 (m, 2H, N-CH2-CH2), 1.60-1.45 (m, 4H, 2 * N-CH2). 13C NMR (CDCl3) delta 150.9, 149.6, 139.4, 128.4 (2C), 128.1 (4C), 127.3 (2C), 126.1 (2C), 125.8 (2C), 125.3 (3C), 125.2 (2C), 81.4, 62.7, 53.8 (2C), 43.8, 26.2 (2C). HRMS (ESI) m/z: calcd for C27H25F6NO [M + H]+ 494.1919; found 494.1883.

10315-06-7, The synthetic route of 10315-06-7 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Kondengaden, Shukkoor M.; Luo, Liu-fei; Huang, Kenneth; Zhu, Mengyuan; Zang, Lanlan; Bataba, Eudoxie; Wang, Runling; Luo, Cheng; Wang, Binghe; Li, Keqin Kathy; Wang, Peng George; European Journal of Medicinal Chemistry; vol. 122; (2016); p. 382 – 393;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39514-19-7,Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

STEP A: l -Benzyl-3-oxo-piperidine-4-carboxylic acid ethyl ester (5.0 g, 16.8 mmol) was stirred in dry ethanol (55 mL). The flask was evacuated and filled with nitrogen prior to the addition of 10percent Pd/C ( 1 .0 g). The resulting suspension was stirred for 16 hours under an atmosphere of hydrogen. The reaction mixture was filtered through Celite and concentrated to afford a yellow solid (2.9 g). This was immediately dissolved in CH2C12 (100 mL), treated with Boc-anhydride (4.4 g, 20.2 mmol) and DIPEA (4.3 g, 33.6 mmol), and stirred for 16 hours at room temperature. The organics were washed sequentially with HCI (IN), water and brine, dried over magnesium sulfate, filtered, and concentrated to afford 3-oxo-piperidine-l ,4-dicarboxylic acid 1 -te -butyl ester 4-ethyl ester as a clear oil (4.8 g, 100percent yield). MS (ESI) m/e (M+H+): 271.36, 39514-19-7

As the paragraph descriping shows that 39514-19-7 is playing an increasingly important role.

Reference：
Patent; NOVARTIS AG; MILLER-MOSLIN, Karen; TOURE, Bakary-Barry; VISSER, Michael Scott; YUSUFF, Naeem; WO2011/29842; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

5274-99-7, 1-Benzoylpiperidine-4-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixed solution of methyl (2RS, 3SR)-2-amino-3-(1H-indol- 3-yl) butanoate (4.65 g), 1-benzoylpiperidine-4-carboxylic acid (5.13 g), WSC (5.75 g) and HOBt (4.60 g) in tetrahydrofuran (70 ML) WAS stirred at room temperature for 12 hrs. The reaction solution was diluted with ethyl acetate, a saturated aqueous sodium carbonate solution was added and the mixture was subjected to extraction. The organic layer was dried (MGS04) and the solvent was evaporated. The residue was purified by silica gel column chromatography (developing solvent: hexane/ethyl acetate = 1/1-ethyl acetate) to give the title compound as a pale yellow oil (7.86 g, yield 88%). 1H NMR (300 MHz, CDCl3) 8 ppm: 1.47 (d, J = 6.9 Hz, 3 H), 1.63 – 1. 83 (m, 4 H), 2.27-2. 35 (m, 1 H), 2.80-3. 00 (m, 2 H), 3.62-3. 78 (m, 4 H), 4.60 (brs, 1 H), 4.86-4. 96 (m, 1 H), 5.86-6. 02 (m, 1 H), 6.99 (d, J = 3.6 Hz, 1 H), 7.08-7. 20 (m, 2 H), 7.33-7. 40 (m, 6 H), 7.55-7. 60 (m, 1 H), 8.22- 8.28 (m, 1 H)., 5274-99-7

5274-99-7 1-Benzoylpiperidine-4-carboxylic acid 78935, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2004/46107; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.220223-46-1,Methyl N-Boc-3-Oxopiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: A solution of Intermediate 55b (0.79 g, 2.9 mmol) and benzyl bromide (0.40 mL,3.4 mmol) in N,N-dimethylacetamide (5 mL) is treated with powdered potassium carbonate (0.5 g, 3.6 mmol) and the mixture is stirred at 65 C overnight. The mixture is cooled, filtered, and concentrated in vacuo. Purification of the crude material by flash chromatography (hexanes/ethyl acetate gradient) affords 1-tert-butyl 3-ethyl 3-benzyl-4-oxopiperidine-1,3-dicarboxylate 55c as a clear oil.

220223-46-1, The synthetic route of 220223-46-1 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Azimioara, Mihai; Alper, Phil; Cow, Christopher; Mutnick, Daniel; Nikulin, Victor; Lelais, Gerald; Mecom, John; McNeill, Matthew; Michellys, Pierre-Yves; Wang, Zhiliang; Reding, Esther; Paliotti, Michael; Li, Jing; Bao, Dingjiu; Zoll, Jocelyn; Kim, Young; Zimmerman, Matthew; Groessl, Todd; Tuntland, Tove; Joseph, Sean B.; McNamara, Peter; Seidel, H. Martin; Epple, Robert; Bioorganic and Medicinal Chemistry Letters; vol. 24; 23; (2014); p. 5478 – 5483;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23499-01-6,1-(4-Nitrophenyl)piperidin-4-one,as a common compound, the synthetic route is as follows.

EXAMPLE 224 1-(4-Amino-phenyl)-piperidin-4-one hydrochloride A mixture of 1-(4-nitro-phenyl)-piperidin-4-one (Synthesis 1981, 606) (4.0 g, 18 mmol) and 500 mg of 10% Pd/C in 75 mL of methylene chloride was hydrogenated under H2 (5~10 psi) for 1 hour. The catalyst was then removed by filtering through a short pad of silica gel. The filtrate was treated with hydrogen chloride gas and the precipitate was collected to give 2 g of the title compound as a tan solid; 1H NMR (300 MHz, DMSO-d6) delta 2.44 (t, J=6.0 Hz, 4H), 3.65 (t, J=6.0 Hz, 4H), 7.14 (d, J=9.0 Hz, 2H), 7.25 (d, J=9.0 Hz, 2H); MS (ES) m/z: 190.9 (MH+); HRMS Calcd. for C11H15N2O (MH+): 190.1106. Found: 190.1096., 23499-01-6

23499-01-6 1-(4-Nitrophenyl)piperidin-4-one 3842562, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Hu, Baihua; Sum, Fuk-Wah; Malamas, Michael S; US2002/28835; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

301225-58-1, tert-Butyl 4-(propylamino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A 4-(N-((4-Nitrobenzyl)oxycarbonyl)-N-(prop-1-yl)amino)-piperidine trifluoroacetate The title compound was prepared by the reaction of 4-(N-(prop-1-yl)amino)-1-tert-butoxycarbonylpiperidine (from Example 17, Step A) with (4-nitrobenzyl)chloroformate, followed by treatment of the product with 50% TFA in CH2Cl2 to remove the tert-butoxycarbonyl group, affording the title compound. ESI-MS: 322.2 (M+H).

301225-58-1, As the paragraph descriping shows that 301225-58-1 is playing an increasingly important role.

Reference：
Patent; Merck & Co., Inc.; US6399619; (2002); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

180307-56-6, tert-Butyl 4-vinylpiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,180307-56-6

Step B: tert-Butyl 4-[(E)-2-(4-Fluoro-l-oxo-13-dihydro-2-benzofuran-5-yl)ethenyllpiperidine- 1-carboxylate To a flask added 5-bromo-4-fluoro-2-benzofuran-l (3H)-one (0.10 g, 0.43 mmol) palladium(II)acetate (0.097 g, 0.043 mmol), triethylamine (0.12 mL, 0.88 mmol) and tert-butyl 4-ethyenylpiperidine-l-carboxylate (0.27 g, 1.2 mmol); the resulting mixture was then dissolved in DMF (15 mL) and heated in an oil bath at 130 C for 2 h. The flask was cooled to room temperature, diluted with EtOAc and washed with saturated sodium bicarbonate and water, then dried (Na2SC>4), filtered and adsorbed into silica gel. MPLC (hexanes/EtOAc = 1/1) purification provided tert-butyl 4-[(E)-2-(4-fluoro- 1 -oxo- 1 ,3-dihydro-2-benzofuran-5-yl)ethenyl]piperidine- 1-carboxylate. LC/MS: [(M+2)]+ =233.

180307-56-6 tert-Butyl 4-vinylpiperidine-1-carboxylate 10910832, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng; WO2013/39802; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem