Tag: M.W:200-300

109384-19-2, tert-Butyl 4-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of tert-butyl 4-hydroxypiperidine- 1 -carboxylate (5 g, 24.84 mmol, 1.00 equiv) and HC1 (saturated solution in 30 mL of 1 ,4-dioxane) was stirred for 2 h at room temperature. The resulting mixture was concentrated under vacuum to afford the title compound (3.4 g, 99percent) as an off- white solid.

109384-19-2, The synthetic route of 109384-19-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; CHEN, Huifen; CHU, Yanyan; DO, Steven; ESTRADA, Anthony; HU, Baihua; KOLESNIKOV, Aleksandr; LIN, Xingyu; LYSSIKATOS, Joseph P.; SHORE, Daniel; VERMA, Vishal; WANG, Lan; WU, Guosheng; YUEN, Po-wai; WO2015/52264; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62718-31-4,1-Benzylpiperidine-4-carbonitrile,as a common compound, the synthetic route is as follows.

62718-31-4, Step a: To a solution of N,N-diisopropylamine(14.0 mE, 97.5 mmol) in THF (100 mE) was added (at -78 C. and under N2) n-butyllithium (1.6 M in hexane; 59.0 mE, 94.25 mmol) dropwise. The resulting mixture was stirred for30 mm at RT. 1-benzyl piperidine-4-carbonitrile (6.5 g, 32.5 mmol) in THF (50 mE) was added at -78 C. After stirring for 30 mm at this temperature, n-propyl iodide (20.5 mE, 211.3 mmol) was added. The resulting mixture was stirred at-78 C. for 1 h. The mixture was quenched by addition of saturated aqueous ammonium chloride solution and it was extracted with EtOAc. The combined organic phases were washed with brine, dried over Na2504, filtered and concentrated to obtain 1 -benzyl-4-propylpiperidine-4-carbonitrile (6.0 g, 24.8 mmol). This compound was used without further purification. MS mlz 243 (M+H).

62718-31-4 1-Benzylpiperidine-4-carbonitrile 793383, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; NOVARTIS AG; Chen, Zhuoliang; Dore, Michael; Fortanet, Jorge Garcia; Karki, Rajesh; Kato, Mitsunori; LaMarche, Matthew J.; Perez, Lawrence Blas; Williams, Sarah; Sendzik, Martin; (63 pag.)US2017/1975; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

885279-92-5, 1-Boc-1,8-diaza-spiro[4.5]decane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,885279-92-5

A flask was charged with 1, 1, 1,3,3,3 -hexafluoropropan-2-ol (2.00 g, 1 1.9 mmol, 1.50 equiv), DCM (20 mL) and triphosgene (1.18 g, 3.97 mmol, 0.50 equiv). N,N- diisopropylethylamine (2.55 g, 19.7 mmol, 2.50 equiv) was added dropwise at 0 C. The solution was stirred for 3 h at room temperature. Then t-butyl l,8-diazaspiro[4.5]decane-l- carboxylate (1.90 g, 7.91 mmol, 1.00 equiv) was added. The resulting solution was stirred overnight at room temperature and quenched by water (20 mL), as described in Example 6, Step 4. The residue was chromatographed on a silica gel column to provide 1.58 g (46% yield) of -t- butyl 8-(l, l, l,3,3,3-hexafluoropropan-2-yl) l,8-diazaspiro[4.5]decane-l,8-dicarboxylate as a yellow oil. LCMS (ESI, m/z): 435 [M+H]+.

The synthetic route of 885279-92-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ABIDE THERAPEUTICS, INC.; GRICE, Cheryl A.; WEBER, Olivia D.; BUZARD, Daniel J.; SHAGHAFI, Michael B.; JONES, Todd K.; (275 pag.)WO2019/46318; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

135716-08-4, tert-Butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The above resulting product (639mg,2.4mmol) dissolved in 6ml of methanol, Underargon added the argon was replaced with hydrogen three times and reaction was carried out overnightin a hydrogenation apparatus (4 atm H2). The reaction solution was filteredthrough celite and washed with ethyl acetate. The filtrate was concentrated andseparated by column chromatography to give a white solid, 722 mg, 100percent yield. theabove resulting product(506mg,1.9mmol) dissolved in 10ml of ether, reaction was colled down to -20 ° C, added diisobutylaluminum hydride(1.0M,5mL,5mmol), reaction was carried out for 10 minutes until the starting material disappeared. Then Poured into saturated sodium potassium tartrate solution, stirred at room temperature for 3 hours to clarify the reaction mixture,the aqueous phase was extracted three times with ether and the organic phases were combined and washed with saturated NaClsolution and dried over Na2SO4, After Concentration, carriedout column chromatography separation to obtain a White solid, 368mg, yield 86percent.

135716-08-4, As the paragraph descriping shows that 135716-08-4 is playing an increasingly important role.

Reference：
Patent; Peking University; ZHANG, FENG YING; WANG, BIN; HUANG, BIN; JIA, YAN XING; (19 pag.)CN102952072; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118133-15-6,1-(Ethoxycarbonyl)piperidine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Under anhydrous conditions, take Intermediate 14.02 (20mmol) in 25mL round bottom flask was added N,N’-carbonyldiimidazole (CDI) 4.21g (26mmol), was added freshly distilled THF 8ml, was stirred at room temperature for 4h, rotary evaporation remove THF, directly in the next reaction without purification., 118133-15-6

As the paragraph descriping shows that 118133-15-6 is playing an increasingly important role.

Reference：
Patent; Kunming Xianghao Technology Co., Ltd.; Luo Huairong; Hong Xuechuan; Zhu Xi; Zhu Jinmei; Wu Guisheng; Deng Zixin; Zhu Yingmin; Lu Yungang; Deng Ke; Qu Chunrong; (25 pag.)CN103694242; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

24686-78-0, 1-Benzoylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) 4-Amino-1-benzoyl-piperidine-4-carbonitrile was prepared from N-benzoyl-4-piperidone according to the procedure from Example 9, step a. MS, m/z 168=M+1, 24686-78-0

The synthetic route of 24686-78-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Emmanuel, Michel Jose; Hickey, Eugene R.; Liu, Weimin; Spero, Denice Mary; Sun, Sanxing; Thomson, David S.; Ward, Yancey David; Young, Erick Richard Roush; US2002/58809; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

936130-82-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.936130-82-4,Methyl 4-(piperidin-4-yl)benzoate hydrochloride,as a common compound, the synthetic route is as follows.

Water (0.4 mL), paraformaldehyde (0.742 g, 24.71 mmol) and acetic acid (1.415 mL, 24.71 mmol) were added to a stirred suspension of methyl 4-piperidin-1-ium-4-ylbenzoate chloride (1.58 g, 6.18 mmol) in THF (40 mL) under nitrogen. Sodium cyanoborohydride (0.582 g, 9.27 mmol) was added portion wise over a period of 10 mins. The resulting mixture was stirred at 60 C. for 18 h. The reaction mixture was evaporated to dryness and mixed with water (30 mL) and 1M HCl (10 mL). The solution was washed with ethyl acetate (2×25 mL), basified with solid potassium carbonate and extracted ethyl acetate (2×25 mL). The organic layer was washed with saturated brine and dried over MgSO4, filtered and evaporated to afford pure methyl 4-(1-methylpiperidin-4-yl)benzoate (0.784 g, 54.4%) as a colourless oil which solidified on standing. 1H NMR (399.9 MHz, DMSO-d6) delta 1.62-1.71 (2H, m), 1.72-1.74 (2H, m), 1.95-2.02 (2H, m), 2.21 (3H, s), 2.54-2.59 (1H, m), 2.88 (2H, d), 3.85 (3H, s), 7.39-7.42 (2H, m), 7.88-7.91 (2H, m). MS: m/z 234 (MH+).

936130-82-4 Methyl 4-(piperidin-4-yl)benzoate hydrochloride 42614593, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ASTRAZENECA AB; US2008/153812; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1245648-32-1,tert-Butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of 2-(benzo[djthiazol-2-yl)acetonitrile (300 mg, 1.72 mmol) in ethanol (10 mL) was added tert-butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate (460 mg, 1.72 mmol), elemental sulfur (55 mg, 1.72 mmol) and morpholine (150 mg, 1.72 mmol) at room temperature and the resulting reaction mixture was heated to reflux at 85 °C for 4 h and monitored by TLC. The reaction mixture was dried under vacuum pressure and the crude compound was purified by trituration with methanol to afford the mixture of the title compounds as an off white solid (700 mg, yield 89percent). LCMS: [M+Hj = 456.0; R = 3.50 mm, [M+Hj = 455.9; R = 3.59 mm., 1245648-32-1

The synthetic route of 1245648-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SYROS PHARMACEUTICALS, INC.; ROBERTS, Christopher; ZHANG, Yi; BEAUMIER, Francis; LEPISSIER, Luce; MARINEAU, Jason, J.; RAHL, Peter, B.; SPROTT, Kevin; CIBLAT, Stephane; SOW, Boubacar; LAROUCHE-GAUTHIER, Robin; BERSTLER, Lauren; (469 pag.)WO2016/197078; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

122860-33-7, Benzyl 4-(hydroxymethyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

26c. Phenylmethyl 4-formylpiperidinecarboxylate To a stirred solution of oxalyl chloride (2M solution in dichloromethane, 10.9 mL, 21.9 mmol) was added DMSO (3.1 mL, 3.4 g, 43.8 mmol) in dichloromethane (6 mL) over a period of 15 minutes. The product of Example 26b (4.4 g, 17.5 mmol) in dichloromethane (7 mL) was then added at -78 C. over a period of 15 minutes. The resultant solution was stirred at -78 C. for 1 hour and then triethylamine (12.2 mL, 8.86 g, 87.5 mmol) was added, dropwise, over a period of 15minutes. The mixture was further stirred at -78 C. for 30 min and then at 0 C. for 15 min. The reaction mixture was quenched with water and extracted with dichloromethane. The combined organic phase was washed with 1% HCl, water, dried over sodium sulfate, filtered and evaporated to give the title compound (4.4 g, 100%) which was used in the next step without purification. 1H NMR (300 MHz, CDCl3) delta9.65 (s, 1H), 7.28-7.38 (m, 5H), 5.12 (s, 2H), 4.04 (br d, J=13.1 Hz, 2H), 2.97-3.06 (m, 2H), 2.38-2.45 (m, 1H), 1.88-1.92 (m,2H), 1.52-1.64 (m, 2H). 13C NMR (75 MHz, CDCl3) delta202.7, 155.2, 136.7, 128.5, 128.6, 127.9, 67.2, 47.8, 43.0, 25.1. LRMS (APIMS) m/z 248 (MH+)., 122860-33-7

122860-33-7 Benzyl 4-(hydroxymethyl)piperidine-1-carboxylate 736490, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Fang, Xinqin; Garvey, David S.; Gaston, Ricky D.; Lin, Chia-En; Ranatunga, Ramani R.; Richardson, Stewart K.; Wang, Tiansheng; Wang, Weiheng; Wey, Shiow-Jyi; US2003/203915; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24666-55-5,Benzyl (2,6-dioxopiperidin-3-yl)carbamate,as a common compound, the synthetic route is as follows.

7.86 g of benzyl 2,6-dioxopiperidin-3-yl carbamate were dissolved in 30 mL of THF and 30 mL of methanol. 0.786 g of 10% Pd/C catalyst was added to the above solution. The mixture was allowed to react under a flow of hydrogen at room temperature for 2h, filtered to remove the catalyst, and evaporated to remove the solvent. A light blue solid (3.818 g) was obtained.

24666-55-5, 24666-55-5 Benzyl (2,6-dioxopiperidin-3-yl)carbamate 2735493, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Tianjin Hemey Bio-Tech Co., Ltd.; EP2093228; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem