Tag: M.W:200-300

10315-06-7, Methyl 1-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Prepared with LiHMDS as Base: A solution of product from Example 32B (2 g, 6 mmol) in tetrahydrofuran (15 ml) was cooled to -20 to -22 C. under a nitrogen atmosphere. A solution of lithium hexamethyldisilazide (LiHMDS) (1.0M in THF, 7.2 ml, 7.2 mmol) was added, dropwise, maintaining the temperature at -20 to -22 C. After the addition, the solution was stirred at -20 to -22 C. for 2 hours. A solution of product from Example 7 (2.26 g, 8 mmol) in tetrahydrofuran (10 ml) was added, dropwise, at -20 to -22 C. The reaction was stirred for an additional 2.5 hours while maintaining the low temperature. The mixture was quenched with saturated ammonium chloride (15 ml) and extracted with ethyl acetate (3*10 ml). The organic extract was dried over anhydrous magnesium sulfate, filtered through silica pad and concentrated to a small residual volume. n-Heptane (10 ml) was add and the solution was left overnight at room temperature to produce 2.4 g (69%) of the product as white crystals. HPLC: 90% pure., 10315-06-7

10315-06-7 Methyl 1-benzylpiperidine-4-carboxylate 11436222, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Sandanayaka, Vincent P.; Zask, Arie; Venkatesan, Aranapakam M.; Baker, Jannie L.; Krishnan, Lalitha; Megati, Sreenivasulu; Zeldis, Joseph; US2002/99035; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

24666-55-5, Benzyl (2,6-dioxopiperidin-3-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-N-benzyloxycarbonylamino-2,6-piperidinone hydrochloride 40 g (0.153 mol) was added to a 1 L reaction flask.40% hydrobromic acid solution 300ml, acetic acid 400ml,Stir well and mix well, heat to 60 C, keep warm for 1 h,Cool to room temperature, distill off the solvent and water under reduced pressure.Add 1 L of ethyl acetate to the residue and stir for 0.5 h.The product was white filtered to give a white solid (30.4 g, yield: 95.2%)., 24666-55-5

As the paragraph descriping shows that 24666-55-5 is playing an increasingly important role.

Reference：
Patent; Shijiazhuang Duen Pharmaceutical Technology Co., Ltd.; Fang Yu; Du Yumin; (8 pag.)CN109776493; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

19099-93-5, 1-Cbz-Piperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step B. Ben2yl 7′-chloro-2′-oxo-r,2′-dihydro-lH-spiro[piperidine-4,4′-pyrido[2,3- 19099-93-5

The synthetic route of 19099-93-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK & CO., INC.; WO2006/44504; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142851-03-4,Ethyl N-Boc-piperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

To 1-tert-butyl 4-ethyl piperidine-1, 4-dicarboxylate (4.96 g, 19.3 ?tmol) in methanol (20 mL) was added hydrazine hydrate (5 mL) and the mixture was heated to reflux for 3 days . The mixture was concentrated to dryness to give tert- butyl 4- (hydrazinocarbonyl)piperidine-l-carboxylate as a white crystalline solid (4.2 g, 90%) : 1H NMR (400 MHz, DMSO-d6) delta1.39 (s, 9H), 1.39-1.42 (m, 2H), 1.55-1.64 (m, 2H), 2.18-2.27 (in, IH), 2.63-2.76 (m, 2H), 3.89-3.97 (m, 2H), 9.03 (br, IH); m/z (APCI pos) 144.1 (100%) [M+H-Boc] .

142851-03-4, The synthetic route of 142851-03-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/11130; (2008); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

885279-92-5, 1-Boc-1,8-diaza-spiro[4.5]decane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 142: 1,1,1,3,3,3-Hexafluoropropan-2-yl 1-((1-acetyl-1,2,3,4-tetrahydroquinolin-8- yl)methyl)-1,8-diazaspiro[4.5]decane-8-carboxylate Step 1: Preparation of 1-tert-butyl 8-(1,1,1,3,3,3-hexafluoropropan-2-yl) 1,8- diazaspiro[4.5]decane-1,8-dicarboxylat A flask was charged with triphosgene (2.46 g, 8.29 mmol, 0.50 equiv), DCM (100 mL) and HFIP (4.21 g, 24.9 mmol, 1.50 equiv). DIEA (6.45 g, 49.7 mmol, 3.00 equiv) was added dropwise at 0 ^C. The reaction mixture was stirred for 2 h at 0 ^C. tert-Butyl 1,8- diazaspiro[4.5]decane-1-carboxylate (4.01 g, 16.6 mmol, 1.00 equiv) was added, and the reaction was stirred for 3 h at 0 ^C before quenching with H2O (50 mL). The mixture was extracted with DCM (3 x 50 mL) and the organic layers were combined, washed with H2O (3 x 100 mL), dried over anhydrous Na2SO4, filtered, and concentrated. The residue was purified on a silica gel column (1:2 EtOAc/petroleum ether) to provide 4.34 g (60% yield) of 1-tert-butyl 8-(1,1,1,3,3,3- hexafluoropropan-2-yl) 1,8-diazaspiro[4.5]decane-1,8-dicarboxylate as a white solid. LCMS (ESI, m/z): 435 [M+H]+.

885279-92-5, As the paragraph descriping shows that 885279-92-5 is playing an increasingly important role.

Reference：
Patent; ABIDE THERAPEUTICS, INC.; BUZARD, Daniel J.; SHAGHAFI, Michael B.; CISAR, Justin S.; GRICE, Cheryl A.; JONES, Todd K.; WEBER, Olivia D.; (277 pag.)WO2017/197192; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

138022-04-5, tert-Butyl methyl(piperidin-4-ylmethyl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-[1-(2,6-dioxo-3-piperidyl)-3-methyl-2-oxo-benzimidazol-4-yl]but-3-ynyl methanesulfonate (400 mg, 986 umol) and tert-butyl N-methyl-N-(4-piperidylmethyl)carbamate (270 mg, 1.18 mmol, CAS138022-04-5) in MeCN (10 mL) and CHCl3 (10 mL) was added K2CO3 (409 mg, 2.96 mmol). The reaction mixture was stirred at 65 C. for 16 hrs. On completion, the reaction mixture was diluted with water (30 mL) and extracted with EA (3×50 mL). The combined organic layers was dried over Na2SO4, filtered and concentrated in vacuo to give a residue. The residue was purified by reverse phase (0.1% FA condition) to give the title compound (140 mg, 26% yield) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 11.11 (s, 1H), 7.11 (d, J=7.2 Hz, 1H), 7.07-7.02 (m, 1H), 7.01-6.96 (m, 1H), 5.38 (dd, J=5.2, 12.8 Hz, 1H), 3.67 (s, 3H), 3.05 (d, J=6.4 Hz, 2H), 2.96-2.87 (m, 3H), 2.69-2.58 (m, 9H), 2.05-1.94 (m, 3H), 1.58-1.51 (m, 3H), 1.38 (s, 9H), 1.18-1.08 (m, 2H); LC-MS (ESI+) m/z 538.4 (M+H)+.

138022-04-5, The synthetic route of 138022-04-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

77211-75-7, Benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

77211-75-7, EXAMPLE XVI 1-benzyloxycarbonyl-4-hydroxy-4-[N-methyl-N-(ethoxycarbonylmethyl)aminomethyl]piperidine A mixture of 2.7 g of sarcosine ethyl ester and 3.09 g of 6-benzyloxycarbonyl-1-oxa-6-azaspiro[2.5]octane in 20 ml of ethanol is heated to 90 C. for 6 hours in a bomb tube. After cooling overnight, the mixture is evaporated down and the residue is purified by chromatography over a silica gel column with cyclohexane/ethyl acetate (1:1). Yield: 1.8 g (25% of theory); mass spectrum (ESI+): m/z=365 [M+H]+; Rf value: 0.35 (silica gel, cyclohexane/ethyl acetate=1:1).

The synthetic route of 77211-75-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Himmelsbach, Frank; Langkopf, Elke; Jung, Birgit; Blech, Stefen; Solca, Flavio; US2001/44435; (2001); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1158759-06-8,tert-Butyl 3-amino-3-methylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

A solution of tert-butyl 3-amino-3-methylpiperidine-l-carboxylate (0.1091 g, 0.5091 mmol) and TEA (0.1419 mL, 1.018 mmol) in DCM (5.1 mL) was treated with acetic anhydride (72.05 mu, 0.7636 mmol). The reaction was monitored for completion by TLC (EtOAc/ silica, using ninhydrin stain). Upon completion, the reaction mixture was diluted with DCM (40 mL) and washed with brine (3 x 20 mL). The organic extracts were dried over anhydrous MgS04(S), filtered, and concentrated in vacuo. The crude residue was purified by silica chromatography using DCM as eluent to afford title compound (0.104 g, 80% yield). MS (apci) m/z = 157.2 (M+H-Boc).

1158759-06-8, The synthetic route of 1158759-06-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ANDREWS, Steven W.; BLAKE, James F.; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MORENO, David A.; REN, Li; WALLS, Shane M.; (421 pag.)WO2018/136661; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161975-39-9,tert-Butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Amixture of 2 (1eq, 11.72 g, 40 mmol) and lithium bromide (5eq,17.20 g, 200 mmol) in acetone (80 mL) was heated to reflux overnight.The mixture was evaporated, then the residue was partitionedbetween EtOAc and water. The organic layer was washedwith s brine, dried over Na2SO4, filtered, and evaporated to offer the title product 3 as pale yellow oil (9.46 g, 85.40% yield)., 161975-39-9

161975-39-9 tert-Butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate 2765838, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; He, Linhong; Pei, Heying; Zhang, Chufeng; Shao, Mingfeng; Li, Dan; Tang, Mingli; Wang, Taijing; Chen, Xiaoxin; Xiang, Mingli; Chen, Lijuan; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 96 – 112;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

888952-55-4, Methyl 1-Boc-3-methylpiperidine-3-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

888952-55-4, HCl in dioxane 4M (11 mL, 43.5 mmol, 20 eq) was added to 1-(tert-butyl) 3-methyl 3-methylpiperidine-1,3-dicarboxylate (560 mg, 2.18 mmol, 1 eq). The mixture was stirred at room temperature for 3 days.3 The solvent was removed to afford methyl 3-methylpiperidine-3-carboxylate as a yellow solid. [MH]+ 158

The synthetic route of 888952-55-4 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Ouvry, Gilles; Berton, Yael; Bhurruth-Alcor, Yushma; Bonnary, Laetitia; Bouix-Peter, Claire; Bouquet, Karine; Bourotte, Marilyne; Chambon, Sandrine; Comino, Catherine; Deprez, Benoit; Duvert, Denis; Duvert, Gwenaelle; Hacini-Rachinel, Feriel; Harris, Craig S.; Luzy, Anne-Pascale; Mathieu, Arnaud; Millois, Corinne; Pascau, Jonathan; Pinto, Artur; Polge, Gaelle; Reitz, Arnaud; Reverse, Kevin; Rosignoli, Carine; Taquet, Nathalie; Hennequin, Laurent F.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 8; (2017); p. 1848 – 1853;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem