Tag: M.W:200-300

72551-53-2, Ethyl 1-benzylpiperidine-3-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,72551-53-2

A 4N-aqueous sodium hydroxide solution (15 ml) was added to a solution of ethyl 1-benzyl-3-piperidinecarboxylate (7.00 g, 28.3 mmol) in a mixture of tetrahydrofuran (30 ml) and 1,4-dioxane (30 ml), and the resulting mixture was stirred at room temperature for 4 hours. After a 4N-aqueous sodium hydroxide solution (15 ml) was added again, the resulting mixture was stirred overnight at room temperature. After completion of the reaction, the reaction solution was neutralized by the addition of 2N-hydrochloric acid (15 ml) under ice-cooling and the resulting mixture was subjected to azeotropic concentration with toluene. The residue was suspended in ethanol, followed by filtration, and the filtrate was concentrated to obtain 1-benzyl-3-piperidinecarboxylic acid (6.3 g, 100%).

72551-53-2 Ethyl 1-benzylpiperidine-3-carboxylate 2736370, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1403255; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24686-78-0,1-Benzoylpiperidin-4-one,as a common compound, the synthetic route is as follows.

(a) 1-Benzoyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydro- pyridine. In a 1000-ml round-bottomed flask equipped with a Dean-Stark apparatus, a condenser, a calcium chloride guard tube, a magnetic stirrer and oil-bath heating, 94.7 g (0.466 mole) of 1-benzoyl-4-piperidinone, 200 ml of toluene and 52.5 g (0.74 mole) of pyrrolidine are introduced. The mixture is heated under reflux until the water has been completely removed (approximately 3 hours). The mixture is allowed to cool and is evaporated. An orange oil remains.

24686-78-0, As the paragraph descriping shows that 24686-78-0 is playing an increasingly important role.

Reference：
Patent; Synthelabo; US4661498; (1987); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1067915-34-7,Ethyl 1-benzyl-5,5-difluoro-4-oxopiperidine-3-carboxylate,as a common compound, the synthetic route is as follows.

To a suspension of NaH (about 60% in oil, 0.27 g, about 6.8 mmol) in THF (20 mL) was added compound T” (1.01 g, 3.4 mmol) in THF (15 mL), at 0C. After 30 min the ice bath was removed and Tf2NPh (1.82 g, 5.1 mmol) was added. The mixture was heated at 45 C for 72 h. The mixture was allowed to cool to rt, ice was added, and the THF was evaporated under reduced pressure. EtOAc was added, the phases were separated and the organic phase was washed with aq. 10% Na2C03 (lx). The org. extracts were dried over MgS04, filtered, and the solvents were removed under reduced pressure. Purification of the residue by FC (EtOAc/heptane 5: 95 o 1: 9) yielded the title compound (1.46 g, quantitative yield). LC-MS: Rt = 1. 13 min, ES+: 430.13.

1067915-34-7, The synthetic route of 1067915-34-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ACTELION PHARMACEUTICALS LTD; WO2005/40120; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

236406-22-7, 1-Boc-4-(Aminomethyl)-4-methylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Compound 26 (2.0 g, 8.8 mmol) and triethylamine (5.0 mL, 3.6 g, 36 mmol) in CH2Cl2 at 0 C. was added TFAA (1.5 mL, 2.2 g, 11 mmol). The reaction mixture was allowed to warm to rt, and was stirred for 18 h. The reaction mixture was diluted with CH2Cl2 and washed successively with 1 N HCl, water, 1 M aq NaHCO3, and brine. The organic layer was dried over Na2SO4 and filtered. Removal of the solvent gave 2.8 g (100%) of Compound 27.

236406-22-7, 236406-22-7 1-Boc-4-(Aminomethyl)-4-methylpiperidine 23282898, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Schering Corporation; US2004/10013; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

236406-22-7, 1-Boc-4-(Aminomethyl)-4-methylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a homogeneous mixture of tert-butyl 4-(aminomethyl)-4-methylpiperidine- 1- carboxylate (53.0 mg, 0.23 mmol) in anhydrous DCM (2 mL), under nitrogenatmosphere, was added DIPEA (0.17 mL, 0.97 mmol) followed by 4-chlorobenzoyl chloride (0.05 mL, 0.390 mmol). The resulting mixture was stirred at ambient temperature for 4 hours, before being partitioned between DCM and water. The layers were separated and the aqueous layer was extracted twice more with DCM. These organic extracts were combined with the original organic layer and were concentrated invacuo to afford the title compound as an amber residue, which was used in the next step without purification. MS(ES): m/z = 367 [M+H]. tR = 1.00 mm (Method A)., 236406-22-7

236406-22-7 1-Boc-4-(Aminomethyl)-4-methylpiperidine 23282898, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; FLEXUS BIOSCIENCES, INC.; BECK, Hilary Plake; JAEN, Juan Carlos; OSIPOV, Maksim; POWERS, Jay Patrick; REILLY, Maureen Kay; SHUNATONA, Hunter Paul; WALKER, James Ross; ZIBINSKY, Mikhail; BALOG, James Aaron; WILLIAMS, David K.; MARKWALDER, Jay A.; SEITZ, Steven P.; CHERNEY, Emily Charlotte; ZHANG, Liping; SHAN, Weifang; GUO, Weiwei; HUANG, Audris; (231 pag.)WO2016/73774; (2016); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141774-61-0,tert-Butyl (piperidin-2-ylmethyl)carbamate,as a common compound, the synthetic route is as follows.

A solution of 4-nitrophenyl(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)carbamate (2.08 g), tert-butyl (piperidin-2-ylmethyl)carbamate (1.19 g) and TEA (2.20 mL) in N,N-dimethylacetamide (25.0 mL) was stirred at room temperature for 2 hr. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (2.17 g). 1H NMR (300 MHz, CDCl3) delta 1.36-1.54 (11H, m), 1.63-1.83 (4H, m), 2.70 (1H, t, J = 12.5 Hz), 3.12-3.28 (1H, m), 3.29-3.43 (1H, m), 4.03-4.22 (1H, m), 4.35 (1H, d, J = 12.5 Hz), 5.01 (1H, brs), 7.77 (2H, d, J = 8.7 Hz), 7.95-8.07 (2H, m), 8.56 (1H, brs) .

141774-61-0, The synthetic route of 141774-61-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Takeda Pharmaceutical Company Limited; KAIEDA, Akira; ISHII, Naoki; NARA, Hiroshi; YOSHIKAWA, Masato; DAINI, Masaki; (63 pag.)EP3342772; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

190906-92-4, tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 1-boc-2-methylpiperidin-4-one (0.55 g, 2.6 mmol, 1 eq) in dry DCM(7.5 mL) was cooled at 0C and DAST (0.68 mL, 5.2 mmol, 2 eq) was added dropwise.The reaction was stirred overnight at 10C, then diluted with DCM (10 mL), washed withNaHCO3 sat. solution (lOmL), 5% citric acid solution in water (10 mL) and finally withbrine (10 mL). The organic layer was dried over anh. Na2504, filtered and evaporated.The residue was purified by flash chromatography on silica gel (eluent 10/90 EtOAc/petroleum ether) affording 0.53 g of pure 1-N-boc-4,4-difluoromethylpiperidine as white solid., 190906-92-4

190906-92-4 tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylate 12992764, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; AXXAM S.P.A.; PEVARELLO, Paolo; LOHMER, Stefan; LIBERATI, Chiara; SENECI, Pierfausto; PESENTI, Cristina; PRANDI, Adolfo; WO2015/118019; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

24666-55-5, Benzyl (2,6-dioxopiperidin-3-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-CBZ-L-glutamic acid 2.81 g (0.01 mol),Urea 1.2g (0.2mol) was added to DMSO to dissolve and reflux at 150 C. After 2 h, the temperature was lowered.HCl gas, a white solid 1.518 g, a yield of 92%;, 24666-55-5

The synthetic route of 24666-55-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Wang Yanping; Yang Yi; Zhang Xiaoling; Zhou Qinghe; Xu Congying; (8 pag.)CN108218833; (2018); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

63845-28-3, 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(3-Chloropyrazin-2-yl)(2-phenylquinolin-7-yl)-methanamine (120.00 mg, 0.35 mmol), EDC (100.64 mg, 0.53 mmol) and HOBt (47.29 mg, 0.35 mmol) were suspended in CH2Cl2 use CH2C12(2 mL) and charge with DIEA (122.00 muL, 0.70 mmol) followed by the addition of l-JV-Cbz-4-piperidineacetic acid (127.56 mg, 0.46 mmol). The reaction mixture was stirred at rt for 16 h. The reaction mixture was diluted with CH2Cl2 (10 mL) and washed with saturated NaHCO3 (2 x 20 mL) and brine (2 x 20 mL). The organic layer was dried over Na2SO4 and concentrated in vacuo. The crude product was purified by a 10 g Jones silica gel (wetted with 50% EtOAc / Hexane, dried loaded onto silica, and run with 60% EtOAc / Hexanes – > 70% EtOAc / Hexanes). The product was evaporated in vacuo which afforded the title compound; 1H NMR (400 MHz, CHLOROFORM-d) delta 8.56 (1 H, d, J=IAT), 8.39 (1 H, d, J= 2.50), 8.23 (1 H, d, J= 4.77), 8.11 (2 H, d, J= 7.06), 7.85 (3 H, dd, J= 8.60, J= 8.38), 7.74 (1 H, s), 7.50 (3H, m), 7.32 (6H, m), 6.78 (1 H, d, J= 7.76), 5.10 (2 H, s), 4.11 (2 H, m), 2.75 (2 H, m), 2.21 (2 H, d, J= 7.00), 2.01 (1 H, m), 1.67 (2 H, m), 1.15 (2 H, d, J= 8.921); MS (ES+): m/z 605.96/606.98/608.93 (100/40/15) [MH+]; HPLC: tR = 3.33 min. (OpenLynx, nonpolar_5min.).

63845-28-3, 63845-28-3 2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid 1502086, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; OSI PHARMACEUTICALS, INC.; WO2009/91939; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61995-20-8,Benzyl 3-oxopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

61995-20-8, To a solution of trimethylsulfoxonium iodide (3.1 g) in dimethyl sulfoxide (40 mL) was added sodium hydride (570 mg), and the mixture was stirred at room temperature for 1 hr. A solution of benzyl 3-oxopiperidine-1-carboxylate (3.0 g) in dimethyl sulfoxide (10 mL) was added under ice-cooling, and the mixture was stirred at room temperature for 16 hr. To the reaction solution was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate and concentrated. The residue was purified by silica gel column chromatography (30% ethyl acetate/hexane to 50% ethyl acetate/hexane) to give the object product (1.9 g, 60%). 1H NMR (300 MHz, CDCl3) delta ppm 1.64-1.88 (m, 4H) 2.65-2.71 (m, 2H) 3.42-3.54 (m, 4H) 5.13 (s, 2H) 7.25-7.37 (m, 5H)

The synthetic route of 61995-20-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Taniguchi, Takahiko; Miyata, Kenichi; Kubo, Osamu; US2010/69351; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem