Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1215071-17-2,tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.,1215071-17-2

[00411] Step 1: Synthesis of tert-butyl 4-(benzylamino)-3,3-difluoropiperidine-1- carboxylate. To a solution of tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate (1.0 g, 4.25 mmol) in DCM (15 mL) was treated with BnNH2(689 mg, 6.38 mmol) followed by addition of NaBH(OAc)3(2.71 g, 12.76 mmol) and the suspension was stirred at room temperature for 16 h., quenched with aqueous NaHCO3solution (10 mL) and extracted with DCM (30 mL x 2). The combined organic layers were washed with water (20 mL x 3) and brine (20 mL), dried over Na2SO4, filtered and concentrated. The resulting residue was purified by preparative TLC (petroleum ether/EA = 3/1) to give tert-butyl 4-(benzylamino)- 3,3-difluoropiperidine-1-carboxylate (570 mg, 41% yiled) as a colorless oil. ESI-LCMS (m/z): 327.2 [M+1]+.

1215071-17-2 tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate 56776981, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; EPIZYME, INC.; CHESWORTH, Richard; MORADEI, Oscar, Miguel; SHAPIRO, Gideon; JIN, Lei; BABINE, Robert, E.; (495 pag.)WO2016/44641; (2016); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

28936-94-9, 8-Benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 20 L reactor 2.4 kg sodium hydroxide were dissolved in 10 L water. The solution was mixed with 614 g 1.38 (8-benzyl-1 ,3,8-triaza-spiro[4.5]decane-2,4-dione) and the resulting reaction suspension was heated to 80C. When 80C was reached, the reaction mixture was heated in steps of 10C. When the temperature reached 105C the mixture started to foam strongly. Stirring was continued at 108C overnight. The reaction mixture was cooled to 10C and 5 L concentrated hydrochloric acid were added dropwise to obtain a pH 7-8. During the addition the temperature was kept at 23C. The precipitate was filtered and dried in vacuo at 40C over 3 days, then at 80C overnight.Yield: 469.7 g I.39 (85% of theory), 28936-94-9

The synthetic route of 28936-94-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; FIEGEN, Dennis; FLECK, Martin; HOFFMANN, Matthias; KLICIC, Jasna; EAST, Stephen, Peter; NAPIER, Spencer, Charles, R.; SCOTT, John; WO2012/101013; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.189442-78-2,1-Boc-N-methoxy-N-methylpiperidine-3-carboxamide,as a common compound, the synthetic route is as follows.

A solution of tert-butyl 3 -(methoxy(methyl)carbamoyl)piperidine- I -carboxylate (1.0 g, 3.7mmol) in 5 ml of DCM was charged with 5 ml of TFA and stirred at room temperature for one hour. The mixture was then concentrated in vacuo and azeotroped twice with toluene. Theresidue was then diluted with 5 ml of THF and 5 ml of methanol and charged withpropionaldehyde (450 mg, 7.7 mmol) and Sodium Triacetoxyborohydride (1.6 g, 7.7 mniol).The mixture was then stirred at room temperature for one hour and concentrated in vacuo. Themixture was then diluted with ethyl acetate and water. The aqueous was discarded and the organic layer was washed once with water, dried over Na2SO4, filtered, and concentrated in vacuo. The residue was then purified by silica-gel chromatography (1 -10% MeOH in DCM) to afford the the title compound (600 mg, 73% yield).

189442-78-2, The synthetic route of 189442-78-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; GEHLING, Victor; HSIAO-WEI TSUI, Vickie; KIEFER, James, Richard, Jr.; LIANG, Jun; MAGNUSON, Steven; NASVESCHUK, Christopher, G.; PASTOR, Richard; ROMERO, F. Anthony; TAYLOR, Alexander, M.; ZHANG, Birong; (287 pag.)WO2016/112284; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

91419-49-7, 1-Boc-3-Carbamoylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91419-49-7, tert-Butyl 3-carbamothioyIpiperidine-l-carboxylate (92):Amide 91 (2.0 g, 8.76 mmol) and Lawesson’s reagent (1.79 g, 4.42 mmol) were stirred in toluene (45 niL) and the mixture heated to 62 C for 4 hours. The mixture was treated with 5 g of silica gel and 15 mL of methanol, and evaporated to dryness. The solid residue was chromatographed over 30 g of silica gel, eluting with CH2Cl2IMeOH (96:4). The product was chromatographed again, eluting with CH2CbMeOH (97:3) and dried to 1.33 g of 92 as a white foam. MS (ESI) m/z 283 [M+K]+. 1H NMR (CDCl3) delta 1.30-1.50 (m, 10 H), 1.55-1.65 (bs, IH), 1.9-2.0 (m, IH), 2.0-2.2 (m, IH), 2.60-2.75 (bs, IH), 3.0-3.2 (bs, IH), 3.3-3.45 (bs, IH), 3.6-3.95 (m, 2H), 7.43 (bs, 2H).

As the paragraph descriping shows that 91419-49-7 is playing an increasingly important role.

Reference£º
Patent; MITHRIDION, INC.; TWOSE, Trevor, M.; ABRAHAM, Brent, D.; COPP, Richard, R.; FARNHAM, James, G.; HANSON, Seth, A.; HENDRICKSON, Michael, L.; OCKULY, Jeffrey, C.; VERDONE, Melinda, L.; WO2010/102218; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

184637-48-7, tert-Butyl 3-aminopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

184637-48-7, A mixture of tert-butyl piperi din-3 -ylcarbamate (70 A) (1.5 g, 7.29 mmol), 4- (trifluoromethoxy)phenylboronic acid (1.5 g, 7.29 mmol), Cu(OAc)2 (1.57 g, 8.75 mmol), and K3PO4 (3.09 g, 14.58 mmol) in DMSO (30 mL) was stirred at 80 C overnight. The mixture was cooled down to room temperature, diluted with water (100 mL), and extracted with EtOAc (50mL x 3). The combined extracts were concentrated under reduced pressure. The residue was purified with column chromatography on silica gel (ethyl acetate in petroleum ether, 10% v/v) to furnish Compound 70B. LC-MS (ESI) m/z: 361 [M+H]+.

The synthetic route of 184637-48-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHAO, Qi; (737 pag.)WO2019/133770; (2019); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.143900-44-1,(S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

(S)-tert-butyl 3-(tosyloxy)piperidine-1-carboxylate: To a stirred solution of (S)-tert-butyl 3-hydroxypiperidine-1-carboxylate (50 g, 1.0 eq), TsC1 (4-methylbenzene-1- sulfonyl chloride, 52 g, 1.1 eq) and DMAP (4-dimethylamiopryidine, 2.5g) in 500 mL CH2C12 at 0 C was added Et3N (51 g, 2.0 eq). After addition was completed, the reaction mixture was warmed to r.t. and stirred at that temperature for 40 hours. The organic layer was washed with water and brine, dried with anhydrous Na2SO4, and purified by flash chromatography to give the product as a white solid (80 g, 9 1%). ?H NMR (400 MHz, CDC13) oe 7.80 (d, J = 8.0 Hz, 2H), 7.34 (d, J = 8.0 Hz, 2H), 4.46 (brs, 1H), 3.54-3.58 (m, 1H), 3.31-3.40 (m, 3H), 2.45 (s, 3H), 1.80-1.88 (m, 1H), 1.65-1.79 (m, 2H), 1.47-1.52 (m, 1H), 1.43 (s, 9H).

143900-44-1, The synthetic route of 143900-44-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CENTAURUS BIOPHARMA CO., LTD.; HAN, Yongxin; YU, Rong; WANG, Zanping; LIANG, Zhi; HU, Quan; ZHU, Li; HU, Yuandong; SUN, Yinghui; ZHAO, Na; PENG, Yong; ZHAI, Xiaofeng; LUO, Hong; XIAO, Dengming; WO2014/82598; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

159874-38-1, Benzyl 4-(ethylamino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Benzyloxycarbonyl-4-(N-ethylformamido)piperidine. A stirred solution of 1-benzyloxycarbonyl-4-(N-ethylamino)piperidine (1.5 g) in triethyl orthoformate (10 mL) containing a catalytic amount of p-toluenesulfonic acid was heated at 90 C. for 12 hours. The reaction mixture was diluted with 1.0 N hydrochloric acid (10 mL), stirred for 30 minutes, diluted with water, and extracted with dichloromethane. The organic extracts were washed (aqueous sodium bicarbonate, water), dried, and evaporated to an oil that slowly solidified. The solid was suspended in ether and filtered to give the formamido compound (1.0 g) as a white solid; MS: m/z=291(M+1); NMR: ca. 1.5:1 mixture of rotamers, 8.15 (s,0.6), 8.11 (s,0.4), 7.36 (m,5), 5.14 (m,2), 4.30 (m,2.4), 3.43 (m,0.6), 3.25 (m,2), 2.82 (m,2), 1.73 (m,4), 1.21 (t,1.2, J=7.2), 1.15 (t,1.8, J=7.1).

159874-38-1, As the paragraph descriping shows that 159874-38-1 is playing an increasingly important role.

Reference£º
Patent; Zeneca Limited; US5576333; (1996); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

181269-69-2, tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

NaBH4 (2.18 g, 57.7 mmol) was added to a solution of compound 27B (6.10 g, 28.8 mmol) in ethanol (200 ml) at 0 C. over a period of 20 min. After 30 min, the reaction mixture was concentrated. EtOAc (150 ml) was added, and the mixture was washed with brine, dried (Na2SO4), filtered, and concentrated to provide 5.45 g (25.5 mmol, 88%) of compound 38 as a colorless oil. MS: m/e 160 (M-56).

181269-69-2, 181269-69-2 tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate 22644642, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; SCHERING CORPORATION; US2005/182095; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

158407-04-6, tert-Butyl 4-(bromomethyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-butyl 4-((2S)-8-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-6-oxo-2-trifluoromethyl-3,4-dihydro-2H,6H-pyrimido[1,2-a]pyrimidin-1-ylmethyl)piperidine-1-carboxylate 788 mg (2.84 mmol) of tert-butyl 4-bromomethylpiperidine-1-carboxylate and 425 mg (2.84 mmol) of sodium iodide are added to a solution of 690 mg (2.18 mmol) of (8S)-2-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-8-trifluoromethyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 2.13 g (6.54 mmol) of cesium carbonate in 10 mL of acetonitrile. The reaction mixture is heated in a Biotage microwave reactor at 100 C. for 3 hours. The reaction medium is evaporated to dryness and the residue is taken up in EtOAc and washed with water and with saturated NaCl. The organic phase is dried over magnesium sulfate and evaporated to dryness. The residue is purified by chromatography on silica gel (eluent: 95/5 DCM/MeOH) to give 510 mg of tert-butyl 4-((2S)-8-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-6-oxo-2-trifluoromethyl-3,4-dihydro-2H,6H-pyrimido[1,2-a]pyrimidin-1-ylmethyl)piperidine-1-carboxylate, the characteristics of which are as follows: LC/MS (method G): ESI+ [M+H]+: m/z 514 tr (min)=2.45 1H NMR (300 MHz, delta in ppm, DMSO-d6): 0.93-1.03 (m, 1H), 1.11-1.32 (m, 3H), 1.38 (s, 9H), 1.44-1.64 (m, 2H), 1.76-1.91 (m, 2H), 1.99-2.39 (m, 3H), 2.78-3.32 (m, 5H), 3.60 (m, 1H), 3.71 (m, 1H), 3.86-3.99 (m, 2H), 4.06-4.19 (m, 2H), 4.48-4.92 (m, 3H).

158407-04-6, The synthetic route of 158407-04-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; El-Ahmad, Youssef; Filoche-Romme, Bruno; Ganzhorm, Axel; Marciniak, Gilbert; Muzet, Nicolas; Ronan, Baptiste; Vivet, Bertrand; Zerr, Veronique; US2015/183804; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.309956-78-3,(R)-tert-Butyl piperidin-3-ylcarbamate,as a common compound, the synthetic route is as follows.

Reaction of l-[4-chloro-6-(4-morpholinyl)-l,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-lH-benzimidazole with ter/-butyl (3lambda)-piperidinylcarbamate gave tert-butyl (3R)- 1 -[4-[2-(difluoromethyl)-4-methoxy- 1 H-benzimidazol- 1 -yl]-6-(4- morpholinyl)-l,3,5-triazin-2-yl]piperidinylcarbamate in 94 % yield: mp (Ceta2Cl2/hexanes) 115-118 0C; 1H nuMR (DMSO-^6) (retainers) delta 8.00 and 7.89 (2d, J = 8.1, 8.4 Hz, IH), 7.72 and 7.69 (t, JH? = 52.6, 52.7 Hz, lH),7.43-7.36 (m, IH), 6.95 (d, J = 7.9 Hz, IH), 6.95 (br, exchangeable with D2O, IH), 4.53-4.43,4.37-4.31 and 4.21-4.13 (3m, IH), 3.97 (s, 3H), 3.79 (m, 4H), 3.69 (m, 4H), 3.42-3.36 (m, 2H), 3.16-3.10 and 3.02-2.96 (2m, 2H) 1.88-1.79 (m, 2H), 1.55-1.40 (m, 2H), 1.40 and 1.38 (2s, 9H)., 309956-78-3

The synthetic route of 309956-78-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AUCKLAND UNISERVICES LIMITED; WO2009/120094; (2009); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem