Tag: M.W:200-300

71233-25-5,71233-25-5, 1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Na (4.24 g, 184 mmol, 4.37 mL, 2.50 eq) in EtOH (400 mL) was added 1 -tert- butyl 4-ethyl 3-oxopiperidine-l,4-dicarboxylate (20.0 g, 73.7 mmol, 1.00 eq) and acetic acid methanimidamide (11.5 g, 111 mmol, 1.50 eq) under N2. The mixture was stirred at 70 ¡ãC for 5 hours. The reaction mixture was adjusted to pH 7 with HCl (IN), extracted with DCM (3 x 200 mL), washed with brine (1 chi 400 mL), dried over Na2S04, filtered and concentrated under vacuum to give tert-butyl 4-hydroxy-6,8-dihydro-5H-pyrido [3,4-d]pyrimidine-7-carboxylate (16.0 g, 63.7 mmol, 86.4 percent yield) as a brown solid. ESI MS m/z 274.0 [M+H]+.

71233-25-5 1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate 15852989, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA, INC.; FISCHER, John, P.; FELL, Jay, Bradford; BLAKE, James, F.; HINKLIN, Ronald, Jay; MEJIA, Macedonio, J.; HICKEN, Erik, James; CHICARELLI, Mark, Joseph; GAUDINO, John, J.; VIGERS, Guy, P.A.; BURGESS, Laurence, E.; MARX, Matthew, Arnold; CHRISTENSEN, James, Gail; LEE, Matthew, Randolf; SAVECHENKOV, Pavel; ZECCA, Henry, J.; (529 pag.)WO2017/201161; (2017); A1;,
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Piperidine | C5H11N – PubChem

1312412-87-5, tert-Butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0148] Method H-Step d: Tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4-c]pyridine- 5(4H)-carboxylate [0149] A mixture of tert-butyl 3-bromo-2,4-dioxopiperidine-l-carboxylate (292 mg, 1 mmol), thiourea (76 mg, 1 mmol) and NaHCC>3 (84 mg, 1 mmol) in ethanol (4 mL) was heated at 80C for 2 hours. The reaction mixture was then cooled to room temperature and the solids were filtered off. The filtrate was evaporated in vacuo to give a residue that was crystallized from EtOH. The white crystals thus obtained were filtered off and dried to yield 200 mg (74.3% for two steps). *H NMR (400 MHz, DMSO-i5) delta 8.08 (s, 2H), 3.89 (t, J Hz, 2H), 2.75 (t, / = 6.4 Hz, 2H), 1.44 (s, 9H)., 1312412-87-5

1312412-87-5 tert-Butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate 69919790, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ZHANG, Xiaohu; WO2014/113191; (2014); A1;,
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Piperidine | C5H11N – PubChem

138022-02-3, tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(E)-3-(4-Chloro-2-((5-methyl-2 H-tetrazol-2-yl) methyl)phenyl)acrylic acid (Intermediate A)(200 mg, 0.718 mmol) and tert-butyl 4-((methylamino)methyl)piperidine-1-carboxylate (154mg, 0.718 mmol) were dissolved in DMF (3 ml). DIPEA (501 ul, 2.87 mmol) was added followed by 50percent T3P? solution in DMF (838 ul, 1.435 mmol) and the mixture was stirred at room temperature overnight. The resulting mixture was concentrated in vacuo. The residue was dissolved in EtOAc and washed with 10percent citric acid, saturated bicarbonate solution,brine, dried over MgSO4, filtered and concentrated in vacuo. Purification by chromatography on silica eluting with a gradient of EtOAc in iso-hexane afforded the title compound; LCMS: Rt 1.26 mins MS mlz 389.5 [M+H-Boc]+ Method 2minLowpHvol., 138022-02-3

138022-02-3 tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate 21934652, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; BAETTIG, Urs; BEATTIE, David; LEGRAND, Darren Mark; LISTER, Andrew Stuart; MCKENNA, Jeffrey; PEARCE, David William; SANDHAM, David Andrew; STANLEY, Emily; STEWARD, Oliver Ross; THOMSON, Christopher; WO2015/8229; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.625471-18-3,(S)-tert-Butyl 3-aminopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.,625471-18-3

Amino derivative 43a (1.05 g, 5.24 mmol), 2,5-diamino-4,6-dichloropyrimidine 17 (1.03 g, 5.76 mmol), and triethylamine (3.1 ml, 22.53 mmol) were suspended in n-butanol (80 ml) and heated to 140 ¡ãC in a pressure vessel over 48 h. After the reaction was completed, the solvent was evaporated and the residue chromatographed on a silica gel using a linear gradient of ethyl acetate in toluene. The product was obtained in a 54percent yield (969 mg, 2.82 mmol) as a light orange foam.1H NMR, 13C NMR, and IR spectra were identical to those of 33b. HRMS (ESI) C14H24O2N6Cl (M+H)+ calcd 343.1644, found 343.1645; [alpha]D20 -31.1 (c 0.106, EtOH).

625471-18-3 (S)-tert-Butyl 3-aminopiperidine-1-carboxylate 1501975, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Kovac?kova?, Son?a; Drac?i?nsky?, Martin; Rejman, Dominik; Tetrahedron; vol. 67; 7; (2011); p. 1485 – 1500;,
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161491-24-3, 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In the reaction flask,N-Boc-3-carboxylate-4-piperidone 25 g (0.1 mol)Added to methanol 300mL,Ammonium acetate 22g (0.3 mol) was further added,Reaction overnight,TLC monitoring raw material reaction is complete, dry methanol, add water 900mL,The reaction mixture was extracted with 300 mL of dichloromethane three times,The combined organic phases were dried over anhydrous sodium sulfate,Dried to get a red oily liquidN-Boc-3- carboxylateAmino-3-ene-piperidine 25g

161491-24-3, As the paragraph descriping shows that 161491-24-3 is playing an increasingly important role.

Reference£º
Patent; Mao Jiajing; (22 pag.)CN107286160; (2017); A;,
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Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.782501-25-1,1-Boc-4-Chlorosulfonylpiperidine,as a common compound, the synthetic route is as follows.

782501-25-1, A solution of tert-butyl 4-(chlorosulfonyl)piperidine-1-carboxylate (3.000 g, 10.572 mmol) in dichloromethane (50 mL) was mixed at the room temperature with 3-chloroaniline (1.618 g, 12.686 mmol) and triethylamine (2.210 mL, 15.858 mmol), and stirred at the same temperature for 18 hr. Then, water was added to the reaction mixture, followed by extraction with dichloromethane. The organic layer was washed with aqueous saturated sodium chloride solution, dried with anhydrous Mg504, filtered, and concentrated in vacuo. The residue was chromatographed (5i02, 40 g cartridge; ethyl acetate / hexane = 20 % to 50 %) to give the concentrate, and then the concentrate was dissolved in ethyl acetate (10 mL) and hexane (100 mL) and stirred. The resulting precipitates were collected by filtration, washed by hexane, and dried to give tert-butyl 4-(N-(3-chlorophenyl)sulfamoyl)piperidine- 1-carboxylate as white solid(0.860 g, 21.7 %).

782501-25-1 1-Boc-4-Chlorosulfonylpiperidine 45789737, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Jaekwang; HAN, Younghue; KIM, Yuntae; CHOI, Daekyu; MIN, Jaeki; BAE, Miseon; YANG, Hyunmo; KIM, Dohoon; (644 pag.)WO2017/18803; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129888-60-4,tert-Butyl 3-((methylsulfonyl)oxy)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

[0373] Step1. A 20 mL vial fitted with a magnetic stir bar was charged with pyrimidine 1(303 mg), mesylate 9 (300 mg) (tert-Butyl3-(methylsulfonyloxy)piperidine-1-carboxylate (9) was prepared according toCosta, et al, J. Med. Chem. 1992, 35, 4334-4343), cesium carbonate (450 mg),and DMF (2 mL). The reaction mixture was heated to 50 C. and stirred for 3 d.The reaction mixture was diluted with water (20 mL) and extracted with EtOAc(3¡Á20 mL). The organic layers were combined, washed with water (3¡Á20 mL) andbrine (1¡Á20 mL). The organic layer was dried over Na2SO4, filtered, andconcentrated under reduced pressure. The resulting residue was redissolved inDCM (3 mL), and treated with TFA (1 mL) and water (0.5 mL). The reactionmixture was stirred for 5 minutes at room temperature and the solutionconcentrated under reduced pressure. The residue was treated with TFA (1 mL)and stirred for 5 minutes and concentrated twice more. The residue was thendiluted with EtOAc and washed with 5% NaHCO3. The organic layer was thenextracted with 1 M HCl. The acid washes were neutralized with NaOH andextracted with EtOAc. The resulting organic layer was dried over Na2SO4,filtered, and concentrated under reduced pressure. The resulting residue wasredissolved in DCM (5 mL) and combined with cyanoacetic acid (170 mg), HOBt(130 mg), DIPEA (0.2 mL), and EDC (250 mg). The reaction mixture was stirredovernight at room temperature. The reaction mixture was diluted with EtOAc,washed with 5% citric acid, followed by 5% NaHCO3, and then brine. The organiclayer dried over Na2SO4, filtered, and concentrated under reduced pressure. Theresulting residue was partially purified by Si-gel chromatography to give3-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperi-din-1-yl)-3-oxopropanenitrile (10) 156 mg (34% yield over 3 steps).

129888-60-4, 129888-60-4 tert-Butyl 3-((methylsulfonyl)oxy)piperidine-1-carboxylate 568122, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Taunton, JR., John William; Brameld, Kenneth Albert; Goldstein, David Michael; Mcfarland, Jesse; Krishnan, Shyam; Choy, Jonathan; US2014/323464; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.189442-92-0,1-Boc-4-Formyl-4-methylpiperidine,as a common compound, the synthetic route is as follows.

Step 3. Synthesis of 4-aminomethyl-1-t-butoxycarbonyl-4-methylpiperidine To a solution of 367 mg of N-t-butoxycarbonyl-4-methylpiperidine-4-carbaldehyde in 5 ml of methanol, 1.2 g of ammonium acetate and 130 mg of sodium cyanoborohydride, followed by stirring for 1 hour at room temperature. The reaction mixture was diluted with chloroform, washed sequentially with a 3N sodium hydroxide aqueous solution and brine, and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to give the title compound., 189442-92-0

189442-92-0 1-Boc-4-Formyl-4-methylpiperidine 22248051, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Banyu Pharmaceutical Co Ltd; US6140333; (2000); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.940890-90-4,(S)-tert-Butyl 3-((methylsulfonyl)oxy)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

3-(4-phenoxyphenyl) lH-pyrazolo [3,4-d] pyrimidin-4-amine (1.14g, 3.76mmol)was dissolved DMF (30mL) in, and then the reaction solution was added (S)-tert-butyl 3-((methylsulfonyl) oxy) piperidine-1-carboxylate (4.2g, 15.04mmol), cesium carbonate(0.64mL, 8.21 mmol), 4- dimethylaminopyridine pyridine (3.67g, 11.28mmol). Was stirredat 90 deg.] C 8h, the reaction was completed, distilled under reduced pressure of DMF,and extracted with dichloromethane (150mL ¡Á 3), brine (60mL), dried over anhydroussodium sulfate, the solvent was distilled off under reduced pressure, the crude productwas silica gel column Analysis of separation and purification (methylene chloride /methanol (V / V) = 40/1), to give the product (1.28g, 70percent)., 940890-90-4

The synthetic route of 940890-90-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangdong HEC Pharmaceutical Co., Ltd; LIU, BING; BAI, SHUN; ZHANG, YINGJUN; ZHENG, CHANGCHUN; YANG, TIPING; ZHOU, YOUBAI; (33 pag.)CN105399756; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1038866-44-2, Spiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 581-(6-(7-methyl-2-(tetrahydrofuran-3-yl)-1H-benzo[d]imidazol-5-yloxy)pyrimidin-4-yl)spiro-[piperidin-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one; 138 mg (0.54 mmol) spiro[piperidin-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one hydrochloride, 180 mg (0.54 mmol) 5-(6-chloropyrimidin-4-yloxy)-7-methyl-2-(tetrahydrofuran-3-yl)-1H-benzo[d]imidazole and 280 muL (1.62 mmol) DIPEA in 5.0 mL DMF were stirred overnight at 60 C. The reaction mixture was combined with ice water. The precipitate formed was suction filtered and purified by chromatography. The fractions containing product were combined and evaporated down i.vac. to leave the aqueous residue. This was neutralised with an aqueous NaHCO3 solution and extracted with ethyl acetate. The organic phase was dried and evaporated down i.vac.Yield: 50 mg (18% of theory)ESI-MS: m/z=514 (M+H)+ Rt(HPLC): 2.88 min (method L)

1038866-44-2, As the paragraph descriping shows that 1038866-44-2 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/88755; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem