Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.782501-25-1,1-Boc-4-Chlorosulfonylpiperidine,as a common compound, the synthetic route is as follows.,782501-25-1

Example 128 and 129: tert-Butyl 4-(N-(5-(2-methoxyphenyl)-1,3,4-thiadiazol-2- yl)sulfamoyl)piperidine-1-carboxylate, 128 and N-(5-(2-methoxyphenyl)-1,3,4- thiadiazol-2-yl)piperidine-4-sulfonamide hydrochloride, 129 a) tert- butyl 4-(N-(5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl)sulfamoyl)piperidine-1- carboxylate 128 Lithium bis(trimethylsilyl)amide solution 1.0 M in THF (0.386 mL, 0.386 mmol) was added to a solution of 5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-amine 1109 (0.040 g, 0.193 mmol) in tetrahydrofuran (1.93 mL) at -10 C and the reaction was stirred for 10 min. A solution of tert-butyl 4-chlorosulfonylpiperidine-1-carboxylate (0.066 g, 0.232 mmol) in THF (0.5 mL) was added dropwise, the resulting mixture was warmed to room temperature and stirred overnight. The reaction was quenched with water (5 mL), acidified with 1 M HCI and extracted with EtOAc (3 x 10 mL). The combined organics were washed with brine, dried (MgS04) and concentrated. Purification by column chromatography (4 g silica cartridge, 50- 90% ethyl acetate in petroleum benzine 40-60 C) gave the title compound (0.013 g, 15% yield) as a pale yellow oil. LCMS-C: rt 6.14 min, m/z 453.2 [M-H]-, NMR (400 MHz, CDCIs) d 8.07 (dd, J = 7.9, 1.7 Hz, 1H), 7.47 (ddd, J = 8.4, 7.4, 1.7 Hz, 1H), 7.07 (td, J =7.6, 1.0 Hz, 1H), 7.02 (d, J = 8.4 Hz, 1H), 4.34-4.18 (m, 2H), 3.98 (s, 3H), 3.16 (tt, J = 1 1.9, 3.6 Hz, 1H), 2.80-2.69 (m, 2H), 2.17 (dd, J = 13.6, 3.6 Hz, 2H), 1.77 (qd, J = 12.5, 4.5 Hz, 2H), 1.46 (s, 9H).

As the paragraph descriping shows that 782501-25-1 is playing an increasingly important role.

Reference£º
Patent; CTXT PTY LIMITED; STUPPLE, Paul, Anthony; LAGIAKOS, Helen, Rachel; FOITZIK, Richard, Charles; CAMERINO, Michelle, Ang; NIKOLAKOPOULOS, George; BOZIKIS, Ylva, Elisabet, Bergman; KERSTEN, Wilhelmus, Johannes, Antonius; WALKER, Scott, Raymond; HUBERT, Jonathan, Grant; (0 pag.)WO2020/2587; (2020); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

91419-49-7, 1-Boc-3-Carbamoylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91419-49-7, 3(B) 3-Cyano-piperidine-1-carboxylic acid tert-butyl ester Phosphorus oxychloride (0.64 mL, 6.89 mmol) was added dropwise at 0 C. to a solution of 3-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester (1.58 g, 6.89 mmol) in pyridine (15 mL), under nitrogen atmosphere. After stirring overnight at room temperature, ethyl acetate was added and the solution was washed with 10% HCl (2 times). The phases were separated and the organics were dried over sodium sulphate and evaporated to dryness under reduced pressure. The title compound was used for the next step without further purification. Yield: quantitative; LCMS (RT): 4.48 min (Method A); MS (ES+) gave m/z: 211.1.

The synthetic route of 91419-49-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NIKEM RESEARCH SRL; ADDEX PHARMA SA; US2009/215822; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

103816-19-9, [1,4′-Bipiperidine]-1′-carbonyl chloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

SN-38B-11 (1.22 g, 2.08 mmol, yield 89%, enantiopurity 99.8%ee) was obtained from SN-38 (0.91 g, 2 .32 mmol) synthesized in Example 9 by the reported procedure (Sawada, S.; Okajima, S.; Aiyama, R.; Nokata, K.; Furuta, T.; Yokokura, T.; Sugino, E.; Yamaguchi, K.; Miyasaka, T. Chem. Pharm. Bull. 1991, 39, 1446.).Chiral HPLC operation conditions Column: DAICEL CHIRALCEL OD-H, 0.46cmID¡Á25cm (No.ODH0CE-AK031) Guard cartridge: DAICEL CHIRALCEL OD-H, 0.4cmIDxlcm Injection amount:10mug/10muL Temperature: constant temperature about 40C Flow rate: 1mL/min Mobile phase: dimethylamine : hexane : ethanol mixture(1 : 250 : 250) Detect: 254nm

103816-19-9, As the paragraph descriping shows that 103816-19-9 is playing an increasingly important role.

Reference£º
Patent; Kabushiki Kaisha Yakult Honsha; EP1378505; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

143900-44-1, (S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,143900-44-1

Step 3. To a stirred mixture of 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (5.9 g, 22.6 mmol, 1.00 equiv), (S)-tert-butyl 3-hydroxypiperidine-1-carboxylate (10 g, 50 mmol, 2.2 equiv) and triphenylphosphine (11.8 g, 45 mmol, 2.0 equiv) in tetrahydrofuran (300 mL) at 10 C. was added a solution of diisopropyl azodicarboxylate in tetrahydrofuran (30 mL) dropwise in 30 min. The resulting mixture was stirred at room temperature for 12 h and then concentrated under vacuum. The residue was purified on a silica gel column eluted with dichloromethane/methanol (100/1) to give 3 g (33%) of (R)-tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate as yellow solid.

As the paragraph descriping shows that 143900-44-1 is playing an increasingly important role.

Reference£º
Patent; Taunton, JR., John William; Brameld, Kenneth Albert; Goldstein, David Michael; Mcfarland, Jesse; Krishnan, Shyam; Choy, Jonathan; US2014/323464; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

173186-91-9, 1-Benzyl-3,3-dimethylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 11 4-Methylamino-3,3-dimethylpiperidine Potassium hydroxide (12.85 g, 230 mmol) was added to the stirred solution of methylamine hydrochloride (15.5 g, 230.0 mmol) in methanol (100 ml) and stirring was continued for 30 min at 30 C. 1-Benzyl-3,3-dimethyl-4-piperidone (5 g, 23.0 mmol), was added to the resulting mixture and stirred for 6 hr. Sodium cyanoborohydride (1.45 g, 23.0 mmol) was added to it and reaction mixture was stirred for 15 hr. The reaction mixture was concentrated to dryness, triturated with water, extracted with chloroform, dried (Na2SO4) and concentrated to give 1-benzyl-4-methylamino-3,3-dimethylpiperidine. Yield 5.3 g (99%), C15H24N2, m/z 233 (M+1), PMR (CDCl3): 0.9 (s, 3H), 1.0 (s, 3H), 1.38 (m, 2H), 1.54 (bs, 1H, D2O exchangeable), 1.68-2.1 (m, 4H), 2.4 (s, 3H), 2.86 (m, 1H), 3.4 (dd, 2H), 7.3 (m, 5H)., 173186-91-9

The synthetic route of 173186-91-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wockhardt Limited; US6878713; (2005); B2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.614731-04-3,1-Boc-4-fluoro-4-piperidinecarboxylic Acid,as a common compound, the synthetic route is as follows.

tert-Butyl 4-carbamoyl-4-fluoropiperidine-1-carboxylate (0414) In a 250-mL round-bottom flask were combined 1-[(tert-butoxy)carbonyl]-4-fluoropiperidine-4-carboxylic acid (3 g, 12.13 mmol, 1.00 equiv), DMF (50 mL), NH4Cl (1.75 g, 32.72 mmol, 1.50 equiv), HATU (9.23 g, 24.27 mmol, 2.00 equiv), and iPr2NEt (3.13 g, 24.22 mmol, 2.00 equiv). The resulting solution was stirred overnight at 25 C. The resulting solution was extracted with 200 mL of EtOAc and the organic layers were combined, washed with 5¡Á50 mL of H2O, then applied onto a silica gel column with ethyl acetate/petroleum ether, affording 2.7 g (90%) of the product as a white solid., 614731-04-3

614731-04-3 1-Boc-4-fluoro-4-piperidinecarboxylic Acid 21050397, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Imago Biosciences, Inc.; Rienhoff, JR., Hugh Y.; McCall, John M.; Clare, Michael; Celatka, Cassandra; Tapper, Amy E.; (226 pag.)US2016/237043; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.479630-08-5,1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine,as a common compound, the synthetic route is as follows.

Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-l-carboxylate (1.00 g, 3.34 mmol, 1.5 eq), 6-fluoro- lH-indazol-3-ylamine (337 mg, 2.27 mmol, 1 eq) and potassium phosphate (945 mg, 4.45 mmol, 2 eq) were suspended in l-methoxy-2-propanol (11 mL) in a 20 mL microwave vial. The vial was capped and the mixture was heated in a microwave to 180C for 15 min. After cooling to RT, the suspension was diluted with 20 mL dichloromethane/methanol (4: 1), filtered through a short pad of silica gel with 100 mL dichloromethane/methanol (4: 1) and evaporated in vacuo. The residue was triturated with 4 mL MTBE/ethyl acetate (1 : 1), filterered, washed with ethyl acetate (2 mL) and dried for 16 h at 50C in vacuo to yield the title compound (66 mg, 7% of theory) as colorless solid. LC-MS (Method IB): Rt = 1.01 min, MS (ESIPos): m z = 387 [M+H]+

479630-08-5, The synthetic route of 479630-08-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HASSFELD, Jorma; KINZEL, Tom; KOeBBERLING, Johannes; CANCHO-GRANDE, Yolanda; BEYER, Kristin; ROeHRIG, Susanne; KOeLLNBERGER, Maria; SPERZEL, Michael; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; ELLERMANN, Manuel; WO2015/67549; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

225240-71-1, Ethyl 4-methylpiperidine-4-carboxylate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

400 mg of [5-({[6- (trifluoromethyl)pyridin-2- yl]carbonyl}amino)-2H- indazol-2-yl]acetic acid were reacted with 296 mg of ethyl 4-methylpiperidine-4- carboxylate hydrochloride (1:1) in the presence of EDC, HOBt and triethylamine. This gave 544 mg of ethyl 4-methyl-1-{[5-({[6-(trifluoromethyl)pyridin-2-yl]carbonyl}amino)- 2H-indazol-2-yl]acetyl} piperidine-4-carboxylate as a crude product. Ethanol and THF and 348 mg of lithium hydroxide monohydrate in water were added, and the mixture was stirred overnight and acidified with citric acid solution. Extraction with ethyl acetate and purification by HPLC gave 89 mg of 4-methyl-1-{[5-({[6-(trifluoro-methyl)pyridin-2-yl]carbonyl}amino)-2H-indazol-2-yl]acetyl}piperidine-4- carboxylic acid. 49 mg of thiswere reacted with 15 mg of 1-methylpiperazine in the presence of EDC, HOBt and triethylamine in THF. Purification by HPLC gave 29 mg of N-[2-(2-{4-methyl-4-[(4-methylpiperazin-1-yl)carbonyl]piperidin-1-yl}-2-oxoethyl)-2H-indazol- 5-yl]-6-(trifluoromethyl) pyridine-2-carboxamide. 1H-NMR (300 MHz,DMSO-d6, selected signals): delta = 1.25 (s, 3H), 1.36-1.57 (m, 2H), 1.98-2.22 (m, 5H), 2.27 (br. s., 4H), 3.13 (t), 3.54 (s), 3.60-3.80 (m, 2H), 5.35-5.50 (m, 2H), 7.51-7.63 (m, 2H), 8.17 (dd, 1H), 8.26-8.42 (m, 4H), 10.37 (s, 1H)., 225240-71-1

225240-71-1 Ethyl 4-methylpiperidine-4-carboxylate hydrochloride 19361804, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Pharma Aktiengesellschaft; BOTHE, Ulrich; SIEBENEICHER, Holger; SCHMIDT, Nicole; ROTGERI, Andrea; BOeMER, Ulf; RING, Sven; IRLBACHER, Horst; GUeNTHER, Judith; STEUBER, Holger; LANGE, Martin; SCHAeFER, Martina; (191 pag.)US2016/311833; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

143900-44-1, (S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Diisopropyl diazodicarboxylate (DAID, 1.2 ml) was added to a solution of 1-tert-butyloxycarbonyl-3-(S)-hydroxypiperidine ( 1.0 g,) and triphenylphosphine (2.59g) in tetrahydrofuran (50.0ml). To the resulting yellow solution, 3-(p-phenoxyphenyl)-1,2,5,7-tetraza-1H-inden-4-ylamine (1.0g). was added and warmed till dissolution, and stirred overnight at room temperature. The reaction mixture was filtered and the solvent was distilled under vacuum to get an oily residue, which was further purified by flash chromatography (30-50 % ethyl acetate/ hexane) on silicagel to give 0.3 g (0.3 w/w) of tert-butyloxycarbonyl-(1S)-1-[(3R)-3-piperidyl]-3-(p-phenoxyphenyl)-1,2,5,7-tetraza-1H-inden-4-ylamine as a light brown solid. The resulting solid was dissolved in dichloromethane (5 ml) and trifluoroacetic acid (0.6 ml) was added to it. After completion of reaction, water was added to reaction mass, followed by addition of methyl tert-butyl ether (20.0 ml). The layers were separated and the aqueous layer was basified with potassium carbonate and extracted with dichloromethane (15.0 ml x 2). The organic layer dried over sodium sulfate, filtered and evaporated to yield 0.2 g (0.6 w/w) of title compound as light yellow oil., 143900-44-1

As the paragraph descriping shows that 143900-44-1 is playing an increasingly important role.

Reference£º
Patent; IND-SWIFT LABORATORIES LIMITED; ARUL, Ramakrishnan; SARIN, Gurdeep Singh; WAS, Sandeep; KUMAR, Vishal; (26 pag.)WO2017/163257; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1038866-44-2, Spiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 54(S)-1-(6-(4-methyl-2-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-6-yloxy)pyrimidin-4-yl)-spiro[piperidin-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one; 59 mg (0.23 mmol) spiro[piperidin-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one hydrochloride, 70 mg (0.21 mmol) (S)-6-(6-chloropyrimidin-4-yloxy)-4-methyl-2-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazole and 0.12 mL (0.70 mmol) DIPEA in 2.0 mL DMF were stirred overnight at 40 C. The reaction mixture was purified by preparative HPLC-MS. The fractions containing product were partially evaporated down i.vac. and neutralised with 4M sodium hydroxide solution. The precipitate formed was suction filtered, washed and dried.Yield: 21 mg (18% of theory)ESI-MS: m/z=514 (M+H)+ Rt (HPLC): 1.09 min (method B)

1038866-44-2, As the paragraph descriping shows that 1038866-44-2 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/88755; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem