Brief introduction of 236406-39-6

236406-39-6 8-Boc-2,8-Diazaspiro[4.5]decane 23282900, apiperidines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.236406-39-6,8-Boc-2,8-Diazaspiro[4.5]decane,as a common compound, the synthetic route is as follows.

General procedure: To a stirring solution of tert-butyl piperazine-1-carboxylate 5(3 mmol) or tert-butyl 2,8-diazaspiro[4.5]decane-8-carboxylate 8or in CH3CN (50 mL) was added 1-bromopropan-2-one or but-3-en-2-one (4 mmol) and K2CO3 (5 mmol) at room temperature.The mixturewas stirred for 3e4 h at room temperature and filtered.The filtrate was diluted by H2O (250 mL) and extracted by DCM(100 mL 3). The combined organic layer was washed by brine,dried over anhydrous MgSO4, filtered, and concentrated. The residuewas purified over silica gel column (DCM: MeOH 40: 1) toyield oils compounds 6a-b or 9a-b (yield, 52%e61%)., 236406-39-6

236406-39-6 8-Boc-2,8-Diazaspiro[4.5]decane 23282900, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Apeng; Lv, Kai; Tao, Zeyu; Gu, Jian; Fu, Lei; Liu, Mingliang; Wan, Baojie; Franzblau, Scott G.; Ma, Chao; Ma, Xican; Han, Bing; Wang, Aoyu; Xu, Shijie; Lu, Yu; European Journal of Medicinal Chemistry; vol. 181; (2019);,
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Simple exploration of 1016258-66-4

1016258-66-4, The synthetic route of 1016258-66-4 has been constantly updated, and we look forward to future research findings.

1016258-66-4, 1-tert-Butyl 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To an ice-cold solution of O1-tert-butyl O4-ethyl 4-cyanopiperidine-1,4-dicarboxylate (0.4 g, 1.41 mmol) in 1,4-dioxane (10 mL) was added HCl-dioxane (4 M, 5 mL) solution. The resulting mixture was stirred at rt for 30 minutes. After completion of reaction (by TLC), solvent was evaporated to obtain the product as a solid (0.28 g). MS: 183.27 [M+H]+.

1016258-66-4, The synthetic route of 1016258-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIOTA EUROPE LTD.; US2012/88750; (2012); A1;,
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Brief introduction of 216854-23-8

The synthetic route of 216854-23-8 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216854-23-8,(S)-tert-Butyl piperidin-3-ylcarbamate,as a common compound, the synthetic route is as follows.

General procedure: A test tube equipped with a stir bar was charged with (S)-tert-butyl piperidin-3-ylcarbamate (205 mg, 1.02 mmol) and potassium carbonate (281 mg, 2.03 mmol). 1-(2-Bromoethyl)-2-fluorobenzene (170 muL, 1.22 mmol) and acetonitrile (3.0 mL) were added, and the mixture was heated in an 80 C oil bath. After heating overnight (~18 h), the reaction was partitioned between EtOAc and H2O, and the aqueous layer was extracted with EtOAc. The combined organics were concentrated under reduced pressure. The crude material was purified by silica gel chromatography (Rf in 60:40 hexanes:EtOAc = 0.24) to give the product as a colorless, viscous oil that slowly crystallized on standing (238 mg, 72%)., 216854-23-8

The synthetic route of 216854-23-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hennessy, Edward J.; Saeh, Jamal C.; Sha, Li; MacIntyre, Terry; Wang, Haiyun; Larsen, Nicholas A.; Aquila, Brian M.; Ferguson, Andrew D.; Laing, Naomi M.; Omer, Charles A.; Bioorganic and Medicinal Chemistry Letters; vol. 22; 4; (2012); p. 1690 – 1694;,
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Some tips on 22065-85-6

22065-85-6 1-Benzylpiperidine-4-carbaldehyde 89584, apiperidines compound, is more and more widely used in various fields.

22065-85-6, 1-Benzylpiperidine-4-carbaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 20 Production of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidene]methylpiperidine using a mixed solvent of methanol and toluene and sodium hydroxide and adopting method A Into a 50-mL four-necked flask were charged 2.0 g (10.4 mmol) of 5,6-dimethoxy-1-indanone, 2.5 g (12.3 mmol, 1.2 equivalents) of 1-benzyl-4-formylpiperidine and 24 mL of a mixed solvent (methanol: toluene = 16: 14). After the air in the system was replaced with nitrogen, 0.5 g (12.5 mmol, 1.2 equivalents) of sodium hydroxide was added to the reaction solution with refluxing (65C). After completion of the addition, stirring was continued with refluxing for 1 hour to complete the reaction. Then, the reaction solution was air-cooled until crystals were precipitated. After the precipitation, the reaction solution was further cooled (cooling rate: 36C/hour) and the crystals precipitated at 4C or higher were collected by filtration. The crystals began to be precipitated at 49C. The crystals collected by filtration were washed with water (30 mL) and 6 mL of methanol and dried at 50C (drying time: 2 hours and 35 minutes) to obtain 3.31 g of the crystals of the title compound (yield: 84.3%). 1H-NMR data of these crystals agreed with those obtained in Example 1., 22065-85-6

22065-85-6 1-Benzylpiperidine-4-carbaldehyde 89584, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Eisai R&D Management Co., Ltd.; EP1911745; (2008); A1;,
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Analyzing the synthesis route of 287952-67-4

Big data shows that 287952-67-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.287952-67-4,4-(4-Trifluoromethoxyphenoxy)piperidine,as a common compound, the synthetic route is as follows.

Example 25; Production of (5) -4- [4- (trifluoromethoxy) phenoxy] -l-{ 4- [ (2, 2, 4- trimethyl-1, 3-dioxolane-4-ly) methoxy] phenyl }piperidine; (S) -4- (4-Bromophenoxy)methyl-2, 2, 4-trimethyl-l, 3- dioxolane (2.32 g, 7.7 mmol), 4- [4-(trifluoromethoxy) phenoxy] piperidine (2.0 g, 7.7 mmol),tris (dibenzylideneacetone) dipalladium (0) (0.141 g, 0.15 mmol), 2- dicyclohexylphosphino-2′ – (N, N-dimethylamino) biphenyl (0.145 g, 0.37 mmol), potassium hydroxide (0.864 g, 15.4 mmol),tributylamine (5 mL) , and xylene (46 ml) were mixed, followed by stirring under a nitrogen atmosphere at 80 C for 8 hours. Using HPLC, it was confirmed that (S) -4- [4- (trifluoromethoxy) phenoxy] – l-{4- [ (2,2, 4-trimethyl-l, 3-dioxolane-4- ly) methoxy] phenyl }piperidine was produced with the inversion rate of 99%., 287952-67-4

Big data shows that 287952-67-4 is playing an increasingly important role.

Reference£º
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; YAMAMOTO, Akihiro; SHINHAMA, Koichi; FUJITA, Nobuhisa; AKI, Shinji; OGASAWARA, Shin; UTSUMI, Naoto; WO2011/93529; (2011); A1;,
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Downstream synthetic route of 146093-46-1

As the paragraph descriping shows that 146093-46-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.146093-46-1,4-(Aminoethyl)-1-N-Boc-piperidine,as a common compound, the synthetic route is as follows.

To a solution of 2-(4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-2-yl)benzofuran-7- carboxylic acid (1.0 eq) and 4-(2-Amino-ethyl)-piperidine-l -carboxylic acid tert-butyl ester (1.1 eq) in Nu,Nu-dimethylformamide were added N,N-diisopropylethylamine (2.0 eq) and HATU (1.2 eq). The mixture was allowed to stir for 30 min. It was diluted with brine and extracted with ethyl’ acetate twice. The combined organic extract was washed with brine twice and dried over magnesium sulfate (or extracted with UCT SPE CUBCX -cartr-idge)r4t- was concentrated- and- purified by combi-flashr~or~preparative^ HPLC., 146093-46-1

As the paragraph descriping shows that 146093-46-1 is playing an increasingly important role.

Reference£º
Patent; DONG-A SOCIO HOLDINGS CO., LTD.; KIM, Myeong-seop; PARK, Taesun; YOON, Taeyoung; YANG, Seung Min; KIM, Hae-Sun; KIM, Jun Gyu; (285 pag.)WO2016/68580; (2016); A2;,
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Analyzing the synthesis route of 614730-97-1

614730-97-1 1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine 22248400, apiperidines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.614730-97-1,1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine,as a common compound, the synthetic route is as follows.

614730-97-1, Step B The product from Step A (1.44 g, 6.17 mmol) was dissolved in 6 ml of pyridine and the solution was cooled to 0C. p-Toluenesulfonyl chloride (1.29 g, 6.79 mmol) was added and the mixture was stirred at room temperature for 4 hours. The reaction mixture was diluted with dichloromethane (250 mL) and washed with water (50 mL). The organic phase was dried over Na2SO4, filtered and the solvent was removed. The residue was purified using a Biotage flash chromatography system (ethyl acetate/n-heptane: 20 to 50%) to give a yellowish oil (2.2 g, 92%). 1H-NMR (400 MHz, CDCl3): delta = 7.79 (d, 2H), 7.36 (d, 2H), 3.96 (brs, 2H), 3.03 (m, 2H), 2.46 (s, 3H), 1.80 (m, 2H), 1.63-1.49 (m, 4H), 1.47 (s, 9H)

614730-97-1 1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine 22248400, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; AC Immune S.A.; EP2377860; (2011); A1;,
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New learning discoveries about 252882-61-4

As the paragraph descriping shows that 252882-61-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.252882-61-4,Spiro[indoline-3,4′-piperidin]-2-one,as a common compound, the synthetic route is as follows.

Process 2Production of 1′-{2-(2-trifluoromethoxyphenoxy)acetyl}spiro(indole-3,4′-piperidine)-2(1H)-oneTo a methylene chloride solution (5 mL) of spiro (indole-3,4′-piperidine)-2(1H)-one (50.0 mg, 0.247 mmol), 2-trifluoromethoxyphenoxyacetic acid (58.4 mg, 0.247 mmol), PyBOP (142 mg, 0.272 mmol), and diisopropylethylamine (63.9 mg, 0.494 mmol) were added sequentially at room temperature. The mixture was stirred at the same temperature for 5 hours. The reaction solution was added with water and then extracted with chloroform. The organic layer was dried with anhydrous sodium sulfate, followed by a vacuum concentration. The resultant residue was purified by preparative thin-layer chromatography (hexane:ethyl acetate=1:2) and 1′-{2-(2-trifluoromethoxyphenoxy)acetyl}spiro(indole-3,4′-piperidine)-2(1H)-one (33.0 mg, 31.8%) was obtained as a colorless amorphous solid.1H-NMR (400 MHz, CDCl3) delta; 1.83-1.91 (m, 4H), 3.80-3.86 (m, 1H), 3.90-3.97 (m, 1H), 4.03 (quint, J=6.8 Hz, 1H), 4.24-4.30 (m, 1H), 4.79 (d, J=12.9 Hz, 1H), 4.87 (d, J=12.9 Hz, 1H), 6.91 (t, J=7.8 Hz, 1H), 7.00-7.30 (m, 7H), 8.58 (s, 1H).IR(ATR); 3217,1711,1632,1471,1223,755 cm-1.EI-MS m/z; 420(M+)., 252882-61-4

As the paragraph descriping shows that 252882-61-4 is playing an increasingly important role.

Reference£º
Patent; KOWA CO., LTD.; US2008/306102; (2008); A1;,
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Brief introduction of 1023595-19-8

1023595-19-8, As the paragraph descriping shows that 1023595-19-8 is playing an increasingly important role.

1023595-19-8, 9-Boc-2,9-diazaspiro[5.5]undecane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (2R,6R)-4-(7-cyanopyrazolo[1,5-a]pyridin-4-yl)-6-methyl-morpholin-2- yl]methyl trifluoromethanesulfonate (compound 67c, 30 mg, 71 mumol), tert-butyl 2,9- diazaspiro[5.5]undecane-9-carboxylate (27 mg, 0.11 mmol) in ACN (4 mL) was added K2CO3 (20 mg, 0.14 mmol). After being stirred at rt for 3 hrs, the reaction mixture was diluted with ACN, and filtered through celite. The filtrate was concentrated to give a yellow solid. The solid was dissolved in DCM (2 mL), and TFA (1 mL) was added dropwise. The reaction mixture was stirred at rt for 1.5 hrs, then concentrated to give a crude product which was purified by prep- HPLC to afford Example 67 (34 mg) as a light yellow powder. MS: calc?d 427 (MH+), measured 427 (MH+).1H NMR (400 MHz, METHANOL-d4) d 8.02 (d, J = 3.5 Hz, 1H), 7.45 (d, J = 7.8 Hz, 1H), 6.56 (d, J = 7.9 Hz, 1H), 4.39 (br t, J = 9.4 Hz, 1H), 4.14 – 3.98 (m, 1H), 3.81 – 3.52 (m, 4H), 3.43 – 3.35 (m, 1H), 3.32 – 3.23 (m, 5H), 3.14 – 2.86 (m, 2H), 2.81 – 2.63 (m, 2H), 2.20 – 1.62 (m, 7H), 1.57 – 1.39 (m, 1H), 1.31 (d, J = 6.2 Hz, 3H).

1023595-19-8, As the paragraph descriping shows that 1023595-19-8 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; LIU, Haixia; SHEN, Hong; ZHU, Wei; HU, Taishan; ZHANG, Zhiwei; DEY, Fabian; (91 pag.)WO2020/52738; (2020); A1;,
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New learning discoveries about 157327-41-8

The synthetic route of 157327-41-8 has been constantly updated, and we look forward to future research findings.

157327-41-8, 1-Boc-3-[(Dimethylamino)methylene]-4-oxopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,2-Dimethyl-1 -(2-(methylsulfonyl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)- yl)propan-1-one[00138]To a solution of crude fe/f-butyl 3-((dimethylamino)methylene)-4-oxopiperidine- 1 -carboxylate (see Preparation 2) (10.70 g, 42.1 mmol) and methyl carbamimidothioate hemisulfate (14.05 g, 50.5 mmol, 1 .2 eq.) in DMSO (200 ml_) is added 4M HCI solution in dioxane (1 .1 ml_, 4.2 mmol, 0.1 eq.). The mixture is heated at 130 C overnight. After cooling down to room temperature EtOAc (330 ml_) and DEE (660 ml_) are added, and the organic layer is washed with water (1 L), brine (3 x, each 1 L), dried over Na2S04, and concentrated in vacuo. Purification by flash column chromatography (silica, gradient 100% heptane to 40% EtOAc/heptane) affords 4.6 g (35%, purity 90%) of theintermediate product fe/f-butyl 2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5/-/)- carboxylate., 157327-41-8

The synthetic route of 157327-41-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERZ PHARMA GMBH & CO. KGAA; ABEL, Ulrich; KRUEGER, Bjoern; KUBAS, Holger; MEYER, Udo; ZEMRIBO, Ronalds; SMITS, Gints; WO2012/85167; (2012); A1;,
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