Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123855-51-6,tert-Butyl 4-(hydroxymethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

156 6-(4-Imidazol- 1 – ylmethyl-piperidin- 1 -ylmethyl)-2-( 1 H-indazol-4- yl)-4- mophiholin-4-yl-thieno[3,2-dlpyrimidine.Via 2-chloro-6-(4-imidazol- 1 -ylmethyl-piperidin- 1 -ylmethyl)-4-morpholin-4- yl-thieno[3,2-d]pyrimidine, prepared from 4-imidazol-l-ylmethyl-piperidine.Amine preparation: To a solution of 4-hydroxymethyl-piperidine-l- carboxylic acid tert-butyl ester (250mg), in dry THF (15mL), was added carbon tetrabromide (769mg), and triphenyl phosphine (609mg). The reaction mixture was stirred at room temperature for 24 h, and then the solvents were evaporated in vacuo to give a residue which was purified by flash chromatography to give 4- bromomethyl-piperidine-1-carboxylic acid tert-butyl ester (279mg), as a colourless oil. To a solution of 4-bromomethyl-piperidine-l-carboxylic acid tert-butyl ester (240mg), in dry DMF (5.OmL), was added imidazole (129mg). The reaction mixture was heated in a sealed reaction vial at 1000C for 24 h, then cooled and the contents evaporated onto flash silica for purification. Treatment of this compound with HCl in DCM/MeOH yielded the desired amine, isolated as the hydrochloride salt. 1H NMR (400 MHz, 123855-51-6, 123855-51-6 tert-Butyl 4-(hydroxymethyl)piperidine-1-carboxylate 2764081, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; PIRAMED LIMITED; WO2006/46031; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1029413-55-5,tert-Butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

[0554j A mixture of 2-chloro-4-methoxypyrimidine (970 mg, 6.7 mmol), tert-butyl 4-(4- amino-1H-pyrazol-1-yl)piperidine-1-carboxylate (1.8 g, 6.77 mmol), S-phos (548 mg, 1.35 mmol), Pd2(dba)3 (577 mg, 0.63 mmol) and NaOtBu (1.9 g, 20.2 mmol) in 1,4-dioxane (18 mL) was stirred at 115 C for 2 h under nitrogen. After dilution with EtOAc (200 mL), the mixture was washed with water and brine. The organic phase was concentrated and the residue was purified by silica gel colunm (petroleum ether: EtOAc , 4:1 to 2:1) to give the compound ten?butyl 4-(4-((4-methoxypyrimidin-2-yl)amino)- 1H-pyrazol- 1 -yl)piperidine- 1 -carboxylate (1.15 g, yield: 48%) as a gray solid. ESI-MS (M+H): 375.2.

1029413-55-5, As the paragraph descriping shows that 1029413-55-5 is playing an increasingly important role.

Reference£º
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; MA, Bin; CHAN, Timothy, Raymond; SUN, Lihong; ZHANG, Lei; KUMARAVEL, Gnanasambandam; LYSSIKATOS, Joseph, P.; KOCH, Kevin; MIAO, Hua; WO2015/89337; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

163271-08-7, tert-Butyl (4-methylpiperidin-4-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 6-chloro-3-(2,3-dichlorophenyl)pyrazine-2-carbonitrile (50 mg, 176 mupiiotaomicron, 1 equiv) and ter/-butyl(4-methylpiperidin-4-yl)carbamate (56.5 mg, 264 mupiiotaomicron, 1.5 equiv) in dioxane (1 mL) and DIPEA (1 mL) was warmed to 120 C and stirred for 2 hours. The mixture was then concentrated under reduced pressure to give ter/-butyl(l-(6-cyano-5-(2,3- dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)carbamate (80 mg, crude) as a yellow oil which was used directly in the next step without further purification. LC-MS (ESI): m/z: [M + H] calculated for C22H25C12N502: 462.14; found 462.0., 163271-08-7

The synthetic route of 163271-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; REVOLUTION MEDICINES, INC.; JOGALEKAR, Ash; WON, Walter; KOLTUN, Elena S.; GILL, Adrian; MELLEM, Kevin; AAY, Naing; BUCKL, Andreas; SEMKO, Christopher; KISS, Gert; (496 pag.)WO2018/13597; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

98977-34-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98977-34-5,1-tert-Butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

1-(tert-Butyl) 3-ethyl 4-oxopiperidine-1,3-dicarboxylate (10 g, 36.86 mmol) was suspended in EtOH (200 mL) and cooled to 0¡ãC under a nitrogen atmosphere. Sodiumborohydride (0.7 g, 18.43 mmol) was then added portionwise over 15 minutes and the reaction mixture was stirred for 0.5 h at 25¡ãC. The mixture was evaporated to dryness, the residue was partitioned between EtOAc (200 mL) and saturated aqueous sodium bicarbonate solution (200 mL), then the aqueous layer was washed with EtOAc (2 x 100 mL). The combined organic layers were washed with brine (200 mL), dried overmagn1-(tert-Butyl) 3-ethyl 4-oxopiperidine-1,3-dicarboxylate (10 g, 36.86 mmol) was suspended in EtOH (200 mL) and cooled to 0¡ãC under a nitrogen atmosphere. Sodiumborohydride (0.7 g, 18.43 mmol) was then added portionwise over 15 minutes and the reaction mixture was stirred for 0.5 h at 25¡ãC. The mixture was evaporated to dryness, the residue was partitioned between EtOAc (200 mL) and saturated aqueous sodium bicarbonate solution (200 mL), then the aqueous layer was washed with EtOAc (2 x 100 mL). The combined organic layers were washed with brine (200 mL), dried overmagnesium sulfate and concentrated. The residue was purified by FCC, eluting with 0-100percent EtOAc in heptane, to afford the title compound (7.26 g, 85percent) as a clear yellow oil.OH (500 MHz, CDC13) 4.32-4.25 (m, 1H), 4.19 (q, J7.12 Hz, 2H), 4.13-3.85 (m, 1H), 3.71(dt, J 13.35, 3.62 Hz, 1H), 3.51-3.34 (m, 1H), 3.21-2.82 (m, 1H), 2.67-2.56 (m, 1H), 1.89-1.76 (m, 1H), 1.73-1.60 (m, 1H), 1.46 (s, 9H), 1.28 (t,J7.17 Hz, 3H).esium sulfate and concentrated. The residue was purified by FCC, eluting with 0-100percent EtOAc in heptane, to afford the title compound (7.26 g, 85percent) as a clear yellow oil.OH (500 MHz, CDC13) 4.32-4.25 (m, 1H), 4.19 (q, J7.12 Hz, 2H), 4.13-3.85 (m, 1H), 3.71(dt, J 13.35, 3.62 Hz, 1H), 3.51-3.34 (m, 1H), 3.21-2.82 (m, 1H), 2.67-2.56 (m, 1H), 1.89-1.76 (m, 1H), 1.73-1.60 (m, 1H), 1.46 (s, 9H), 1.28 (t,J7.17 Hz, 3H).

The synthetic route of 98977-34-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UCB PHARMA S.A.; BENTLEY, Jonathan Mark; BROOKINGS, Daniel Christopher; BROWN, Julien Alistair; CAIN, Thomas Paul; CHOVATIA, Praful Tulshi; FOLEY, Anne Marie; GALLIMORE, Ellen Olivia; GLEAVE, Laura Jane; HEIFETZ, Alexander; HORSLEY, Helen Tracey; HUTCHINGS, Martin Clive; JACKSON, Victoria Elizabeth; JOHNSON, James Andrew; JOHNSTONE, Craig; KROEPLIEN, Boris; LECOMTE, Fabien Claude; LEIGH, Deborah; LOWE, Martin Alexander; MADDEN, James; PORTER, John Robert; QUINCEY, Joanna Rachel; REED, Laura Claire; REUBERSON, James Thomas; RICHARDSON, Anthony John; RICHARDSON, Sarah Emily; SELBY, Matthew Duncan; SHAW, Michael Alan; ZHU, Zhaoning; WO2014/9295; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161491-24-3,1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

161491-24-3, A solution of O1-tert-butyl O3-methyl 4-oxopiperidine-1,3-dicarboxylate (1 g, 3.88 mmol) in DMF (100 mL) was cooled to 0¡ã C. followed by portion wise addition of NaH (60percent dispersion of mineral oil, 0.16 g, 3.88 mmol). The resulting mixture was stirred at the same temperature for 15 min followed by addition of MeI (0.7 mL, 11.64 mmol) at 0¡ã C. then stirred at rt for 44 h. After completion of reaction (by TLC), water (100 mL) was added and extracted with EtOAc (3.x.100 mL). The combined organics were washed with brine, dried (Na2SO4), filtered and concentrated under reduced pressure to obtain the product as a yellow oil (0.9 g). MS: 272.12 [M+H]+.

As the paragraph descriping shows that 161491-24-3 is playing an increasingly important role.

Reference£º
Patent; BIOTA EUROPE LTD.; US2012/88750; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.495414-64-7,1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

2-Bromo-1 -(4-fluoro-3-methyl-phenyl)-ethanone (2633.06 mg; 1 1.40 mmol; 1 .00 eq.) was added to a solution of 4-hydroxy-piperidine-1 ,4-dicarboxylic acid 1 -tert-butyl ester (2796.0 mg; 1 1 .40 mmol; 1 .00 eq.) and triethylamine (1 .92 ml; 13.67 mmol; 1 .20 eq.) in acetonitile (30 ml) at rt in one portion. The resulting mixture was stirred at RT for 100 min. The reaction mixture was diluted with 100 ml of ethyl acetate and washed with saturated NaHC03 once and brine twice. The organic layer was dried over MgS04 and then concentrated to yield the title compound as a light brown solid, which was used directly for the next step reaction. LC-MS (M+H = 396, obsd = 396), 495414-64-7

The synthetic route of 495414-64-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK PATENT GMBH; LAN, Ruoxi; CHEN, Xiaoling; XIAO, Yufang; HUCK, Bayard R.; GOUTOPOULOS, Andreas; WO2014/143612; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4876-59-9,4-(Dimethylamino)piperidine dihydrochloride,as a common compound, the synthetic route is as follows.

Dimethyl-piperidin-4-yl-amine dihydrochloride (Aldrich, 2.0 g, 9.95 mmol) and 4-fluoro-nitrobenzene (Aldrich, 2.5 g, 17.7 mmol) were added to methanol (30 mL). The mixture was heated to 90 C. and stirred for 3.5 hours. The mixture was treated with 1 N HCl to pH=1 and then extracted with diethyl ether (2*10 mL). The aqueous layer was treated with saturated sodium carbonate to pH=10 and then extracted with methylene chloride (2*20 mL). The organic layer was dried with sodium sulfate and the solvent was removed to give the desired product. 1.25 g, 50%. MS (m+H)+: 250.

4876-59-9, 4876-59-9 4-(Dimethylamino)piperidine dihydrochloride 22591440, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Ding, Qingjie; Jiang, Nan; Kim, Kyungjin; Lovey, Allen John; McComas, Warren William; US2005/239843; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

352673-16-6, 1-(2-Chlorobenzoyl)piperidine-4-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of1-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetyl)piperidine-4-carboxylic acid(900.00 mg, 2.71 mmol, 1.05eq) and HOBt (488.23 mg, 3.61 mmol, 1.40eq) in DCM (100.00 mL) was added EDCI (692.68 mg, 3.61 mmol, 1.40eq) . The reaction mixture was stirred for 15 min, at which time a solution of(3S)-tert-butyl 3-amino-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy) pentanoate(911.00 mg, 2.58 mmol, 1.00eq) and NMM (783.19 mg, 7.74 mmol, 851.29 uL, 3.00eq) in DCM (100.00 mL) was added and then the mixture was stirred for an additional 60 h at 25 C . The solution was diluted with DCM (100 mL) and washed with saturated aqueous sodium hydrogen carbonate (2 * 50 mL), saturated aqueous sodium chloride (1*100 mL), dried (MgSO4) and concentrated under reduced pressure. The residue was purified by flash silica gel chromatography (ISCO; 12 g SepaFlash Silica Flash Column, Eluent of 0~30%EtOAc/Petroleum ether gradient 36 mL/min) to give(3S)-tert-butyl 3-(1-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetyl)piperidine- 4-carboxamido)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoate(16)(1.24 g, 1.71 mmol, 66% yield) as a yellow oil., 352673-16-6

352673-16-6 1-(2-Chlorobenzoyl)piperidine-4-carboxylic acid 778084, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Mou, Jianfeng; Wu, Songliang; Luo, Zhi; Guo, Fengying; He, Haiying; Wang, Jianhua; Lin, Fusen; Guo, Fengxun; Sun, Jianping; Shen, Liang; Zeng, Minggao; Wang, Chuan; Xu, Deming; Gu, Zhengxian; Tian, Xin; Zhang, Aiming; Xu, Hongjiang; Yang, Ling; Zhang, Xiquan; Li, Jian; Chen, Shuhui; Bioorganic and Medicinal Chemistry Letters; vol. 28; 10; (2018); p. 1874 – 1878;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

134441-61-5, (R)-N-Boc-Piperidine-2-methanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The (2R)-piperidin-2-ylmethanol used as starting material was prepared as follows: Trifluoroacetic acid (3 ml) was carefully added to a stirring solution of tert-butyl (2R)-2- (hydroxymethyl)piperidine-l-carboxylate (1.15 g, obtained as described in Tetrahedron, 58 (2002), 1343 – 1354) in DCM (3 ml) and stirred at room temperature for 1 hour. Volatiles were removed in vacuo and the oil thus obtained dissolved in methanol (60 ml), and neutralized by addition of MP-Carbonate resin (polymer supported carbonate reagent ex. Argonaut Technologies Inc.) (approximately 1 g) whilst stirring at room temperature for 2 hours. The resin was filtered, washed with methanol (3 x 30 ml) and the filtrate concentrated. The resulting oil was dissolved in DCM (30 ml) and dried (MgSO4) before filtration and solvent removal to afford a grey oil (615 mg, 100%); NMR spectrum 1.44 – 1.51 (m, 2H), 1.61 (m, IH), 1.70 – 1.78 (m, 3H), 2.84 (m, IH), 3.03 (m, IH), 3.21 (d, IH), 3.49 (m, IH), 3.57 (dd, IH), 5.01 (bs, IH), 7.65 (bs, IH): Mass spectrum M+ 116., 134441-61-5

134441-61-5 (R)-N-Boc-Piperidine-2-methanol 6933953, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/92574; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39945-51-2,Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Imidazole (3.00 g, 44.0 mmol) and tert-butyldimethylsilyl chloride (6.63 g, 44.0 mmol) were added to 1-(benzyloxycarbonyl)piperidin-3-yl methanol (9.15 g, 36.7 mmol) in N,N-dimethylformamide (40 mL). The solution was stirred at room temperature for 6 hours. Subsequently, water was added and the mixture was extracted with ethyl acetate. The extract was washed with brine and was dried over magnesium sulfate, followed by evaporation of the solvent. Purification of the residue by silica gel column chromatography (hexane: ethyl acetate = 20:1 -> 5:1) gave 13.2 g (99%) of the desired compound as a colorless oil. 1H NMR (400 MHz, CDCl3) delta 0.02 (6H, s), 0.88 (9H, s), 1.11-1.25 (1H, m), 1. 40-1. 53 (1H, m), 1. 61-1.71 (2H, m), 1. 72-1. 80 (1H, m), 2.54-2.66 (1H, m), 2.79 (1H, td, J = 11. 6, 3.1 Hz), 3.34-3.51 (2H, m), 3.99-4.09 (1H, m), 4.12-4.19 (1H, m), 5.12 (2H, s), 7.29-7.39 (5H, m)., 39945-51-2

39945-51-2 Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate 2776577, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; KYORIN PHARMACEUTICAL CO., LTD.; EP1780210; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem