Tag: M.W:200-300

150008-24-5, tert-Butyl 4-(hydroxyimino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of sodium hydride (0.268 g, 7.00 mmol) in DMF (3 ml_) the title compound from Step A above (0.500 g, 2.33 mmol) was added drop wise (dissolved in DMF 5 mL) at 0 (0833) C, then stirred at room temperature for 60 min. After that 2-fluoropyridine (0.340 g, 3.50 mmol) was added dropwise at 0 C (dissolved in DMF 2 mL) and then stirred at room temperature for 3 h. After completion of the reaction by TLC, the reaction mixture was quenched with ice water followed by extraction using ethyl acetate (30 mL). The organic layer was separated, dried over sodium sulphate, filtered and then concentrated to obtain tert-butyl 4-oxo-3-(2-oxo-1 ,2-dihydropyridin-3-yl)piperidine-1-carboxylate (300 mg, crude) as a pale brown solid. The crude product was taken as such for next step. (0834) MS: 293.2 (M+H)+., 150008-24-5

The synthetic route of 150008-24-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (220 pag.)WO2019/134978; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

147539-41-1, tert-Butyl 4-(methylamino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Cbz-protected tert-leucine (500 mg, 1.9 mmol) in dichloromethane (10 ml) was added PyAOP (1. 08 g, 2.1 mmol), HOAt (26 mg, 0. 19 mmol), triethylamine and 4-Methylamino-piperidine-1-carboxylic acid tert-butyl ester (606 mg, 2.8 mmol). The reaction mixture was stirred for 18 h at Rt. The solvent was removed in vacuo and the yellow residue was redissolved in dichloromethane (80 ml) and was washed with 1 M hydrochloric acid (2 x 80 ml), 1 M sodium carbonate (2 x 80 ml), brine (1 x 80 mi) and dried over anhydrous magnesium sulphate to yield a clear oil (2 g). Flash chromatography (2percent MeOH, dichloromethane) yielded the title compound as a white foam (870 mg, 100percent) which contained a slight impurity. HPLC. 6.9 min (85percent); LRMS: +ve ion 462 (M+1, 5percent), 484 (M+Na, 20percent). The compound was progressed to the next step without any further purification.

147539-41-1, 147539-41-1 tert-Butyl 4-(methylamino)piperidine-1-carboxylate 15380702, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BRITISH BIOTECH PHARMACEUTICALS LTD; WO2003/89412; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

163271-08-7, tert-Butyl (4-methylpiperidin-4-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromo-2-(2,3-dichlorophenyl)sulfanyl-3-[(4- methoxyphenyl)methoxy]pyrazine (1.40 g, 2.96 mmol, 1.00 equiv) and tert-butyl N-(4-methyl-4- piperidyl)carbamate (824.66 mg, 3.85 mmol, 1.30 equiv) in toluene (10.00 mL) was added NaOt-Bu (568.91 mg, 5.92 mmol, 2.00 equiv), BINAP (184.3 mg, 0.296.00 mmol, 0.10 equiv) and Pd2(dba)3 (135.53 mg, 0.148 mmol, 0.05 equiv) at 20 C. The mixture was stirred at 130 C by microwave heating for 3 hours under N2. The residue was purified by column chromatography to give tert-butyl N-[l-[5-(2, 3-dichlorophenyl) sulfanyl-6-[(4-methoxyphenyl) methoxy] pyrazin-2-yl]-4-methyl-4-piperidyl] carbamate (500 mg, 0.825 mmol, 27%) as a yellow oil., 163271-08-7

163271-08-7 tert-Butyl (4-methylpiperidin-4-yl)carbamate 19691370, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; REVOLUTION MEDICINES, INC.; JOGALEKAR, Ash; WON, Walter; KOLTUN, Elena S.; GILL, Adrian; MELLEM, Kevin; AAY, Naing; BUCKL, Andreas; SEMKO, Christopher; KISS, Gert; (496 pag.)WO2018/13597; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.147804-30-6,tert-Butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate,as a common compound, the synthetic route is as follows.

A 70% solution of hydrofluoric acid in pyridine (12 mL) was added drop-wise to a solution of intermediate 16 (10 [G)] in anhydrous DCM (200 mL) previously cooled to-40C under a Nitrogen atmosphere. After 1.5 hours, further hydrofluoric acid in pyridine (6 mL) was added. After stirring for further 15 minutes, a saturated sodium hydrogen carbonate solution was added. The layers were separated and the aqueous phase was extracted three times with further DCM. The combined organic extracts were washed with brine, dried and concentrated [IN VACUO] to a residue which was purified by flash chromatography (CH/AcOEt 6: 4) to give the pure title compound (990 mg) and a fraction of title compound (6.01 [G)] impure of pyridine. Thus, this material was diluted with AcOEt and washed three times with a pH3 buffer solution and brine. The organic layer was dried and concentrated in vacuo to give a further amount of title compound (5.12 g). T. [I.] c.: CH/AcOEt 1: 1, [RF=0.] 35. NMR [(D6-DMSO)] : [8] (ppm) 4.99 (t, [1H)] ; 3.79 (m, 2H); 3.43 (dd, 2H); 3.01 (bt, 2H); 1.8-1. 4 (m, 4H); 1.43 (s, 9H)., 147804-30-6

147804-30-6 tert-Butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate 22135564, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/5255; (2004); A1;,
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Piperidine | C5H11N – PubChem

477600-70-7, (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4,6-dichloro-5-methoxy-pyrimidine (0.66g, 3.68mmol) and (3R, 4R) -1- benzyl -N, 4- dimethyl-piperidin-3-amine (0.80g, 3.68 mmol) was dissolved in DMF (5mL), was added potassium carbonate (1.02g, 7.36mmol), 70 reaction was stirred overnight under nitrogen.Water was added (100 mL) to quench the reaction, extracted with ethyl acetate (80mL ¡Á 3), the organic phase was washed with water (50 mL) washed with saturated aqueous sodium chloride solution (50 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure, subjected to column chromatography (eluent: PE / EtOAc (v / v) = 1/1), to give the product 1.13g, yield: 85.0%.

477600-70-7, 477600-70-7 (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 44630604, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Liu, Bing; Huang, Jiuzhong; Ren, Xingye; Li, Zhi; Zhang, Yingjun; Zhang, Changchun; (55 pag.)CN105566321; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

454713-13-4, (R)-tert-Butyl (1-benzylpiperidin-3-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

R-3-(tert-butoxycarbonylamino)-1-benzylpiperidine (20g) was dissolved in 96g of absolute ethanol, added with 5 mass% Pd/C (2g), passed into 20MPa hydrogen, and reacted at 20-25 C. After 20 h, filtration and ethanol washing, the filtrate was combined and evaporated to dryness to give R-3-(tert-butoxycarbonylamino)piperidine (13.4 g), yield 97%., 454713-13-4

454713-13-4 (R)-tert-Butyl (1-benzylpiperidin-3-yl)carbamate 25417446, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Huzhou Fuhuachun Bio-pharmaceutical Technology Co., Ltd.; Feng Lichun; Yang Jianying; (18 pag.)CN110078657; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54288-70-9,4-Bromopiperidine hydrobromide,as a common compound, the synthetic route is as follows.

54288-70-9, To a solution of 4-bromopiperidine hydrobromide (3.0 g, 12.2 mmol) in tetrahydrofuran (30 ml) were added 1-{[(benzyloxy)carbonyl]oxy}-2,5-pyrrolidinedione (3.20 g, 12.9 mmol), N-methylmorpholine (1.62 ml, 14.7 mmol) and 4-N,N-dimethylaminopyridine (30 mg) at room temperature, and stirred at room temperature for 16 hours. The reaction solution was poured into water and extracted with ethyl acetate. The organic layer was washed with a 1N-aqueous hydrochloric acid solution, dried over anhydrous magnesium sulfate and distilled under reduced pressure to remove the solvent, and the resulting residue was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate = 1/1) to obtain benzyl 4-bromo-1-piperidinecarboxylate (3.58 g, 98percent).

The synthetic route of 54288-70-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1403255; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

146093-46-1, 4-(Aminoethyl)-1-N-Boc-piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

146093-46-1, Example 14 (compound No. 234)2,2,2-Trifluoro-1 -(trifluoromethyl)ethyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine- 1 -carboxylate14.1 . ie f-Butyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine-1 -carboxylate; A mixture of 1.12 g (7.15 mmol) of 5-chloropyrazine-2-carboxamide, 1.95 g (8.58 mmol) of ie f-butyl 4-(2-aminoethyl)piperidine-1 -carboxylate and 1 .18 g (8.58 mmol) of potassium carbonate in 1 .4 ml of dimethyl sulphoxide is heated during 5 hours at 100C under an argon atmosphere and with stirring. After cooling to ambient temperature, 25 ml of ethyl acetate and 25 ml of water are added. The organic phase is separated by settling and washed 3 times with 25 ml of water and then 25 ml of a saturated aqueous sodium chloride solution. It is dried over sodium sulphate and evaporated to dryness. The residue is purified by chromatography on silica gel, elution being carried out with a 97:3, then 95:5 and 93:7 mixture of dichloromethane and methanol, in order to obtain 1 .99 g (5.69 mmol) of product in the form of a light-yellow paste.1H NMR (CDCI3, delta ppm, 200 MHz): 8.65 (s, 1 H), 8.10 (s, 1 H), 7.55 (m, 1 H), 5.75 (m, 1 H), 4.85 (m, 1 H), 4.15 (m, 2H), 3.45 (m, 2H), 2.75 (t, 2H), 1 .80-1 .60 (m, 5H), 1 .50 (s, 9H), 1 .35-1 .10 (m, 2H).

As the paragraph descriping shows that 146093-46-1 is playing an increasingly important role.

Reference£º
Patent; SANOFI; BARTSCH, Regine; CHEURET, Dorothee; EVEN, Luc; HOORNAERT, Christian; JEUNESSE, Jean; MARGUET, Frank; WO2011/151808; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1158759-03-5,tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate,as a common compound, the synthetic route is as follows.

Step b: To a solution of 6-chloro-1-methylpyridin-2(1H)-one (55 mg, 0.383 mmol), DIPEA (200 jiL, 1.15 mmol), and tert-butyl ((4-methylpiperidin-4-yl)methyl)carbamate (96 mg, 0.42 1 mmol) in DMF (1 mL) was radiated in a microwave reactor for 2 h at 140 C. After cooling to RT, the reaction mixture was diluted with EtOAc. The organic layer was washed with sat. aq. NH4C1 (2 x) followed by brine. The organic layer was dried over Mg504, filtered, and the volatiles were removed under reduced pressure. The residue was purified by silica chromatography (0 to 100% gradient of EtOAc/heptane) to give tert-butyl ((4-methyl-i -(1- methyl-6-oxo- 1 ,6-dihydropyridin-2-yl)piperidin-4-yl)methyl)carbamate (53 mg, 0.158 mmol). ?H NMR (400 MHz, DMSO-d6) oe ppm 7.33 (dd, J=8.9, 7.4 Hz, 1 H), 6.94 (t, J=6.3 Hz, 1 H), 6.10- 6.04 (m, 1 H), 3.35 (s, 3 H), 2.95-2.85 (m, 4 H), 2.77 (s, 2 H), 1.56-1.47 (m, 2 H), 1.42-1.30 (m, ii H), 0.89 (s, 3 H). MS m/z 336.6 (M+H)

1158759-03-5, As the paragraph descriping shows that 1158759-03-5 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79098-85-4,3-(Piperidin-4-yl)indolin-2-one hydrochloride,as a common compound, the synthetic route is as follows.,79098-85-4

EXAMPLE 179 4-(2-Oxo-2,3-dihydroindol-3-yl)-1-(3-phenoxypropyl)piperidine STR215 From a mixture of 4-[2-oxo-2,3-dihydroindol-3-yl)piperidine hydrochloride (198 mg, 0.73 mmol), 3-phenoxy-propyl chloride (476 mg, 2.22 mmol) and K2 CO3 (138 mg) in toluene (15 mL) was obtained 170 mg (70%) of the title compound as a yellow oil, 1 H NMR (CDCl3): 1.42-1.50 (m, 2H), 1.79-2.03 (m, 6H), 2.10-2.15 (m, 1H), 2.47-2.52 (m, 2H), 2.90-3.04 (m, 2H), 3.408 (d, 1H, J=3.5), 7.001 (t, 1H, J=7.5), 7.022 (t, 1H, J=7.5), 7.23-7.29 (m, 3H), 7.909 (s, 1H). The hydrochloride mp 182-3 C.

The synthetic route of 79098-85-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Warner-Lambert Company; Cocensys, Incorporated; US6124323; (2000); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem