Tag: M.W:200-300

236406-39-6, 8-Boc-2,8-Diazaspiro[4.5]decane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: tert-butyl 2- [6-(Methylsulfonyl)pyridin-3 -yll-2,8-diazaspiro [4.5 ldecane-8-carboxvlate:A stirred solution of 5-bromo-2-(methylsulfonyl)pyridine (0.1 g, 0.5 mmol), tert-butyl 2,8- diazaspiro [4.5] decane-8-carboxylate (commercially available from multiple vendors, for example AstaTech, Inc. catalog 11097; 0.1 g, 0.4 mmol), Pd2dba3 (0.02 g, 0.02 mmol), 5-Phos (0.03 g, 0.08 mmol), and Cs2CO3 (0.4 g, 1.2 mmol) in THF (20 mL) were heated to reflux for 12h. The solution was diluted with H20 and stirred vigorously. The organic layer was removed,dried over MgSO4, filtered and concentrated giving rise to an oil. The oil was purified using a 25 g Biotage SNAP cartridge (7-60% EtOAc:hexanes) giving rise to title compound. LCMS: m/z 396.20 (M+H)., 236406-39-6

As the paragraph descriping shows that 236406-39-6 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP; TANG, Haifeng; PIO, Barbara; JIANG, Jinlong; PASTERNAK, Alexander; DONG, Shuzhi; FERGUSON, Ronald Dale, II; GUO, Zack Zhiqiang; CHOBANIAN, Harry; FRIE, Jessica; GUO, Yan; WU, Zhicai; YU, Yang; WANG, Ming; WO2015/17305; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.187834-88-4,1-Boc-isonipecoticacidhydrazide,as a common compound, the synthetic route is as follows.

To triphosgene (355 mg) was added methylene chloride (3 ml) . To the mixture were added dropwise 3- chloroindazole (458 mg) and triethylamine (1.95 ml) dissolved in methylene chloride (3 ml) with stirring at 0C The reaction solution was warmed to room temperature, stirred for 30 minutes, and then cooled to 0C again. To the reaction solution were added dropwise tert-butyl 4- (hydrazinecarbonyl) iperidine-l-carboxylate (730 mg) and triethylamine (0.63 ml) dissolved in methylene chloride (3 ml) , and the mixture was stirred at room temperature for 4 hours. To the reaction solution was added saturated sodium carbonate aqueous solution, and the resultant solution was extracted with chloroform. The organic layer was dried over sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica-gel chromatography (developing solvent: chloroform / methanol = 95/5) to give tert-butyl 4-({2-[.(3- chloro-lH-indazol-1- yl) carbonyl] hydrazinyljcarbonyl) piperidine-l-carboxylate (519 mg) .LC-MS, m/z; 422 [M+H] +, 187834-88-4

The synthetic route of 187834-88-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAINIPPON SUMITOMO PHARMA CO., LTD.; MIZUNO, Kazuhiro; IKEDA, Junya; NAKAMURA, Takanori; IWATA, Masato; OTAKA, Hiromichi; GOTO, Nana; WO2012/169649; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10315-07-8, 1-Benzylpiperidine-4-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2-bromo-5,6-dimethoxy-1-indanone 64 (0.30 g,1.11 mmol, 1.0 eq.), silver (I) oxide (0.26 g, 1.13 mmol,1.5 eq.), and 1-benzylpiperidin-4- carboxylic acid 66 (0.32 g, 1.46 mmol, 1.3 eq.) inacetonitrile (25 ml) was stirred overnight at 60 C. The reaction mixture was cooled to 20 C and filtered through a pad of celite, and the solvent was removed in vacuo. To the crude product mixture was added ethyl acetate (30 ml) and the organic layer was washedwith 3M aqueous hydrochloric acid (3 x 25 ml). The acidic aqueouslayers were combined and basified with solid potassium carbonate.Dichloromethane (20 ml)was then added and the organic layerwasseparated. Finally the aqueous layer was washed with additionaldichloromethane (2 x 20 ml). The organic fractions were combined,dried over anhydrous sodium sulfate, filtered and evaporatedin vacuo to yield 5,6-dimethoxy-1-oxo-2,3-dihydro-1Hinden-2-yl 1-benzylpiperidine-4-carboxylate 67, as a light brownoil (0.39 g, 85%). The product was used without any further purification.Rf 0.12 (3:1 ethyl acetate: hexane); numax (neat)/cm-1 2949, 1736, 1698, 1593, 1499, 1454, 1305, 1261, 1113, 1072, 1007, 853, 739,698; 1H NMR (300 MHz, CDCl3); delta 7.50e7.43 (m, 2H, ArH’s),7.40e7.30 (m, 3H, ArH’s), 7.16 (s, 1H, ArH), 6.84 (s, 1H, ArH), 5.43(dd, 1H, J 4.3 & 7.7 Hz, COCHOCO), 3.96 (s, 3H, OCH3), 3.89 (s, 3H,OCH3), 3.84 (s, 2H, CH2Ph), 3.52 (dd, 1H, J 7.7 & 16.8 Hz,CH2aCHCO), 3.08e2.98 (m, 2H, CH2N & CHCO2), 2.93 (dd, 1H, J 4.2& 16.8 Hz, CH2bCHCO), 2.65 (s, 2H, CH2N), 2.29e2.14 (m, 2H, CH2 &CH2N), 2.12e2.01 (m, 3H, CH2); 13C NMR (75 MHz, CDCl3); delta 199.10,173.61, 156.70, 150.13, 146.10, 130.54, 128.85, 128.75, 127.18, 107.57,104.80, 74.40, 61.90, 56.47, 56.28, 51.10, 33.07, 26.08, 26.04; HRMSm/z (ESI) 410.1961 ([M + H] requires 410.1962).

10315-07-8, The synthetic route of 10315-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; van Greunen, Divan G.; Cordier, Werner; Nell, Margo; van der Westhuyzen, Chris; Steenkamp, Vanessa; Panayides, Jenny-Lee; Riley, Darren L.; European Journal of Medicinal Chemistry; vol. 127; (2017); p. 671 – 690;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

89151-44-0,89151-44-0, N-Boc-4-Piperidineethanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(viii) 4-(2-Bromo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester A mixture of 4-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (94.0 Og 0.41 mol), carbon tetrabromide (198.7 g 0.6 mol) and dichloromethane (1500 ml) at 0 under nitrogen was treated portionwise, over 45 min, with triphenylphosphine (135.2 g 0.515 mol). The mixture was stirred for 1 h at 10 and 1 h at 25 and then evaporated in vacuo. The residue was purified by flash column chromatography on silica gel (Merck 9385), eluant cyclohexane: ethyl acetate (15:1, gradient to 10:1) to give the title compound as a clear liquid (81.8 g, 0.28 mol, 68%).

89151-44-0 N-Boc-4-Piperidineethanol 854140, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Glaxo Group Limited; US5861414; (1999); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.123855-51-6,tert-Butyl 4-(hydroxymethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

A solution of 1 g (4.41 mmol) of tert-butyl 4-hydroxymethylpiperidine-1-carboxylate in 25 mL of THF is cooled to 0 C. 1.34 g (5.07 mmol) of triphenylphosphine and 2.02 g (5.96 mmol) of carbon tetrabromide are then added. The reaction mixture is stirred at room temperature over the weekend. The solution is taken up in ethyl ether, the insoluble matter is filtered off and the organic phase is evaporated to dryness. The residue is purified by chromatography on silica gel (eluent: 80/20 EtOAc/heptane) to give 960 mg of tert-butyl 4-bromomethylpiperidine-1-carboxylate, the characteristics of which are as follows: LC/MS (method G): ESI+ [M+H]+: m/z 279 tr (min)=2.13 1H NMR (300 MHz, delta in ppm, CDCl3): 1.09-1.29 (m, 2H), 1.47 (s, 9H), 1.71-1.88 (m, 3H), 2.62-2.78 (m, 2H), 3.31 (d, 2H), 4.07-4.25 (m, 2H).

123855-51-6, 123855-51-6 tert-Butyl 4-(hydroxymethyl)piperidine-1-carboxylate 2764081, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; El-Ahmad, Youssef; Filoche-Romme, Bruno; Ganzhorm, Axel; Marciniak, Gilbert; Muzet, Nicolas; Ronan, Baptiste; Vivet, Bertrand; Zerr, Veronique; US2015/183804; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1155-56-2,1-Benzyl-N-phenylpiperidin-4-amine,as a common compound, the synthetic route is as follows.

Reference Example 3 To a mixture of N-(1-benzyl-4-piperidinyl)aniline (1.8 g), diisopropyl ether (20 ml) and triethylamine (0.87 g) is added dropwise a solution of beta-n-butoxyacrylic acid chloride (1.4 g) in diisopropyl ether (5 ml) with stirring and heating at 70 C. After completion of dropwise addition, the mixture is further stirred with heating at the same temperature for 0.5 hour. After cooling, water is added to the reaction mixture and the mixture is subjected to extraction with ethyl acetate. The extract is washed with water and dried over magnesium sulfate. The solvent is distilled off under reduced pressure and the resulting residue is purified by silica gel column chromatography to give N-(beta-n-butoxyacryloyl)-N-(1-benzyl-4-piperidinyl)-aniline (2.6 g). NMR (CDCl3) delta: 0.86 (3H, t, J=7.1 Hz), 1.2-1.4 (1H, m), 1.4-1.6 (2H, m), 1.6-1.9 (2H, m), 2.1-2.3 (1H, m), 2.4-2.6 (3H, m), 2.7-2.9 (1H, m), 3.4-3.7 (4H, m), 4.86 (1H, d, J=12 Hz), 5.1-5.3 (1H, m), 7.1-7.5 (10H, m), 7.47 (1H, d, J=12 Hz)

1155-56-2, The synthetic route of 1155-56-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Otsuka Pharmaceutical Co., Ltd.; US5225402; (1993); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98977-34-5,1-tert-Butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

98977-34-5, To a stirred solution of 4-oxo-piperidine-1 ,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (14 g) in MeOH (300 mL) was added NaBhU (12 g) in 12 lots over 1 h period. After completion of addition, the reaction mixture was stirred for 30 min. Removed solvent under reduced pressure, to the residue was added saturated NH4CI solution (300 mL) and was extracted with EtOAc (300 mL). The organic layer was dried, filtered and concentrated under reduced pressure. The residue was purified by flash silica gel column chromatography by eluting with ethyl acetate to give 4-hydroxy-3-hydroxymethyl- piperidine-1-carboxylic acid tert-butyl ester (10.1 g, cis/trans mixture).

As the paragraph descriping shows that 98977-34-5 is playing an increasingly important role.

Reference£º
Patent; TRANSTECH PHARMA, INC.; GOHIMUKKULA, Devi, Reddy; JONES, David; QABAJA, Ghassan; ZHU, Jeff, Jiqun; COOPER, Jeremy, T.; BANNER, William, Kenneth; SUNDERMANN, Kurt; BONDLELA, Muralidhar; RAO, Mohan; WANG, Pingzhen; GOWDA, Raju, Bore; ANDREWS, Robert, C.; GUPTA, Suparna; HARI, Anitha; WO2011/103091; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91419-53-3,1-N-Boc-3-Cyanopiperidine,as a common compound, the synthetic route is as follows.

91419-53-3, Step 4. Piperidine-3-carbonitrile hydrochloride; A 250-mL 3-necked round-bottomed flask was charged with tert-butyl 3-cyanopiperidine-1-carboxylate (5.8 g, 27.07 mmol, 1.00 equiv, 98%) in 1,4-dioxane (60 mL). The mixture was cooled down to at 0 C. and treated with HCl (g). The mixture was stirred for 2 hours at 0 C. resulting in a precipitate that was collected by filtration to afford piperidine-3-carbonitrile hydrochloride as white solid (1.9 g, 48%).

91419-53-3 1-N-Boc-3-Cyanopiperidine 2756785, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Kalypsys, Inc; US8080566; (2011); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39945-51-2,Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Example 8 Synthesis of 3-formyl-piperidine-1-carboxylic acid benzyl ester (9) To a stirring, 0 C. solution of 0.303 g (1.20 mmol) of 3-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester (8) in CH2Cl2 (4.0 mL) was added 0.630g (1.44 mmol) of Dess-Martin periodinane, and the solution was stirred under N2. When the reaction was complete by TLC (about 30 min.), the reaction was concentrated, and then Et2O was added. After standing for about 15 min., the reaction was filtered through Celite wet with Et2O, rinsed with Et2O, and concentrated. The crude reaction was purified by column chromatography (florisil, 100-200 mesh, 2:1 Hexane: EtOAc) to achieve pure 9.

39945-51-2, The synthetic route of 39945-51-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Aquila, Brian M.; Bannister, Thomas D.; Cuny, Gregory C.; Hauske, James R.; Heffernan, Michele L.R.; Hoemann, Michael Z.; Kessler, Donald W.; Shao, Liming; Wu, Xinhe; Xie, Roger L.; US2002/177721; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.138163-07-2,1-Benzyl 4-methyl piperidine-1,4-dicarboxylate,as a common compound, the synthetic route is as follows.

Step (iii): Benzyl 4-formylpiperidine-1-carboxylate A solution of 1-benzyl 4-methyl piperidine-1,4-dicarboxylate (10 g) in toluene (100 ml) under nitrogen was cooled to -78 C. DIBAL-H (60.9 ml) was then added dropwise at -78 C. and the mixture was stirred at this temperature for 1 h (TLC control). Because the reaction was incomplete, a further 0.2 eq. of DIBAL-H was added and the mixture was stirred for a further 30 min (TLC control: some educt and the corresponding alcohol were to be detected). Methanol (40 ml), followed by sat. sodium chloride solution (40 ml) were added slowly to the reaction mixture at -78 C. The mixture was filtered over Celite and the solvent was removed in vacuo. The residue was extracted with ethyl acetate (3*75 ml) and the extract was dried (Na2SO4) and concentrated in vacuo. The crude product obtained in this way was purified by column chromatography (silica gel, 20% ethyl acetate/hexane). Yield: 4.3 g (49%)

138163-07-2, The synthetic route of 138163-07-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gruenenthal GmbH; US2010/249095; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem