Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.188869-05-8,tert-Butyl 3-bromo-4-oxopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

188869-05-8, General procedure: Enolate 4 (485 mg, 2.5 mmol) was stirred in EtOH (12 mL) with NH4OAc (578 mg, 7.5 mmol). After 5 min the solids had fully dissolved. At this point, chloroacetylaldehyde (50percent in H2O, 0.48 mL, 3.75 mmol) was added and the reaction was warmed to 80 ¡ãC for 1 h. Following cooling to room temperature, AcOH-H2O (4:1, 10 mL) was added and stirring was continued for 30 min. The volatiles were removed under vacuum and the residue was dissolved in CH2Cl2 and washed with H2O. The aqueous was extracted once with CH2Cl2, and the combined organics were dried over Na2SO4 and concentrated. The dark residue was purified by silica gel chromatography [heptane/EtOAc, 9:1-3:1] to give 2-formylpyrrole-3-carbonitrile (1) as an off-white solid, 153.5 mg, 51percent.

As the paragraph descriping shows that 188869-05-8 is playing an increasingly important role.

Reference£º
Article; Moss, Thomas A.; Nowak, Thorsten; Tetrahedron Letters; vol. 53; 24; (2012); p. 3056 – 3060;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.154775-43-6,3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid,as a common compound, the synthetic route is as follows.

Step (a) 3-[1-(tert-Butoxycarbonyl)piperidin-4-yl]propionic acid (4.6 g, 18 mmol), prepared as in Example 1, was dissolved in HMPA (10 mL) and THF (10 mL), and this solution was added to a -20 solution of lithium diisopropylamide (60 mmol). The mixture was warmed to 0 C., stirred for 30 minutes, and then cooled to -40 C. N-Methoxy-N-methyl-4-amino-5-chloro-2-methoxybenzamide (4.9 g, 20 mmol), prepared as in Example 2, was dissolved in HMPA (10 mL) and THF (10 mL) and this solution was added to the mixture. The mixture was allowed to warm to 0 C. over 1 hour, then diluted with water, washed with ether, acidified with hydrochloric acid, and extracted into methylene chloride. The methylene chloride extract was concentrated in vacuo and the residue was heated in an oil bath to 140 C. for 30 minutes. The mixture was cooled, partitioned between water and ethyl acetate. The ethyl acetate layer was separated, washed with 5% sodium hydroxide and then brine, dried over sodium sulfate, and evaporated. Purification by silica gel chromatography (40% ethyl acetate-hexane) gave 1-(4-amino-5-chloro-2-methoxyphenyl)-3-[1-(tert-butoxycarbonyl)piperidin-4-yl]-propan-1-one (1.5 g, 3.8 mmol), m.p. 133-134 C., 154775-43-6

As the paragraph descriping shows that 154775-43-6 is playing an increasingly important role.

Reference£º
Patent; Syntex (U.S.A.) Inc.; US5763458; (1998); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1029413-55-5, tert-Butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2,4-dichioro-i ,3,5-triazine (0.62 g, 4.1 mmol) inN,N-dimethylformamide (DMF, 10 mE) at 0C. were added sequentially N,N-diisopropylethylamine (DIEA, 0.75 mE, 4.3 mmol) and tert-butyl 4-(4-amino-1H-pyrazol–yl)piperidine- 1 -carboxylate (Combi-l3locks, 1.0 g, 3.8 mmol). The mixture was allowed to warm to room temperature. The mixture was diluted with ethyl acetate and water. The aqueous phase basified with saturated aqueous sodium hydrogen carbonate solution and then was extracted thrice with ethyl acetate. The combined extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel) to provide tert-butyl 4-(4-((4- chloro-i ,3,5-triazin-2-yl)amino)- 1H-pyrazol-i -yl)piperidine-i -carboxylate. ECMS-ESI (m/z): [M+H] calcd for C,5H23C1N702: 380.2. found: 379.8

1029413-55-5, As the paragraph descriping shows that 1029413-55-5 is playing an increasingly important role.

Reference£º
Patent; Gilead Sciences, Inc.; Du, Zhimin; Guerrero, Juan A.; Kaplan, Joshua A.; Knox, JR., John E.; Lo, Jennifer R.; Mitchell, Scott A.; Naduthambi, Devan; Phillips, Barton W.; Venkataramani, Chandrasekar; Wang, Peiyuan; Watkins, William J.; Zhao, Zhongdong; (593 pag.)US2016/96827; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161491-24-3,1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

In a reaction flask, methyl N-Boc-3-methylcarboxylate-4-pyridinone 25g (0.1mol) was added to methanol 300mL, then add ammonium acetate 22g (0.3mol), the reaction overnight, TLC monitoring The reaction of raw materials was complete, spin the methanol, add water 900mL, the reaction mixture was extracted three times with 300mL of dichloromethane, the combined organic phase was dried over anhydrous sodium sulfate, and dried to give a red oily liquid N-Boc-3-carboxylic acid methyl ester Amino-3-ene-piperidine 22g, 161491-24-3

161491-24-3 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate 11276893, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Wang Huiqin; (16 pag.)CN107151247; (2017); A;,
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Piperidine | C5H11N – PubChem

159635-22-0, tert-Butyl 3-hydroxy-4-methylenepiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2) 1-t-Butoxycarbonyl-3,4-didehydro-4-(chloromethyl)piperidine To 1-t-butoxycarbonyl-3-hydroxy-4-methylenepiperidine (5.329 g, 25.1 mmol) in toluene (120 mL) and 2,6-lutidine (3.1 mL, 26 mmol) at 0 C. was added SOCl2 (2.0 mL, 26 mmol). The reaction was heated at 40 C. for 30 min, cooled to 0 C., washed with 0 C. 1N HCl (100 mL), 0.1 N HCl (100 mL), H2 O (100 mL), brine (50 mL), dried (MgSO4), and concentrated in vacuo to afford 5.18 g (89%) of allylic chloride as a yellow oil. 1 H NMR (400 MHz, CDCl3) delta 5.78 (s, 1H), 4.04 (s, 2H), 3.95 (s, 2H), 3.55 (t, 2H, J=6 Hz), 2.24 (s, 2H), 1.45 (s, 9H) ppm.

159635-22-0, The synthetic route of 159635-22-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck & Co., Inc.; US6013652; (2000); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79098-75-2,3-Piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one,as a common compound, the synthetic route is as follows.,79098-75-2

EXAMPLE 12 1-[3,5-dibromo-N-[[4-[3,4-dihydro-2(1H)-oxoquinazolin-3-yl]-1-piperidinyl]cyanoiminomethyl]-D-tyrosyl]-4-(4-methyl-1-piperazinyl)piperidine Prepared analogously to Example 7 from N-cyanoiminodiphenylcarbonate, 3,4-dihydro-3-(4-piperidinyl)-2(1H)-quinazolinone and 1-[3,5-dibromo-D-tyrosyl]-4-(4-methyl-1-piperazinyl)-piperidine in a yield of 13% of theory. Colorless, amorphous substance. IR (KBr): 1674 (C=O), 2173 (CN) cm-1 Rf: 0.30 (eluant dichloromethane/methanol/conc. ammonia 8/2/0.2 v/v/v) ESI-MS: (M+H)+=784/786/788 (Br2)

As the paragraph descriping shows that 79098-75-2 is playing an increasingly important role.

Reference£º
Patent; Boehringer Ingelheim Pharma KG; US6313097; (2001); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19395-41-6,Ritalinic acid,as a common compound, the synthetic route is as follows.

Example 8 Conjugation of RA to BTG To a solution of RA (29.6mg, 0.135mmol) in DMF (1.0ml) was added N,N-dicyclohexylcarbodiimide (DCC) (31.0mg, 0.149mmol) and N-hydroxysuccinimide (17.13mg, 0.149mmol) and the mixture was stirred at room temperature overnight. The dicyclohexylurea formed was removed by filtration and the solution was added dropwise to a solution of BTG (150mg) in 50mM sodium bicarbonate solution (pH 8.5) (10ml)., 19395-41-6

19395-41-6 Ritalinic acid 86863, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Randox Laboratories Ltd.; Benchikh, Elouard; Fitzgerald, Peter; Lowry, Philip; McConnell, Ivan; EP2769994; (2014); A2;,
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Piperidine | C5H11N – PubChem

336191-17-4, tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 24 (300.00 mg, 1.25 mmol, 1.00 eq.) and benzoic acid (183.18 mg, 1.50 mmol, 1.20 eq.) in DCM (6 mL) was added NMM (252.88 mg, 2.50 mmol, 2.00 eq.) and T3P (1.19 g, 1.88 mmol, 1.50 eq.). The mixture was stirred at 25 C for 4 hrs.Then the mixture was purified by TLC (PE:EtOAc=1:1) to compound 25 (310.00 mg, 899.99 umol, 72.00% yield). To a solution of compound 25 (310.00 mg, 899.99 umol, 1.00 eq.) in DCM (2 mL) was added HCl/AcOEt (30mL) at 0 C. The mixture was stirred at 25 C for 2 hrs. Then it was concentrated to dryness to give compound 26 (300.00 mg, crude). To a solution of compound 6 (20.00 mg, 66.39 umol, 1.00 eq.) and compound 26 (19.47 mg, 79.67 umol, 1.20 eq.) in pyridine (3.00 mL) was added EDCI (19.09 mg, 99.59 umol, 1.50 eq.) at 25 C , the mixture was stirred for 3 h our at 25 C. LCMS showed the SM consumed, desired product was formed as major product. The reaction was concentrated, dissolved in to DMF (3 mL), purified by prep-HPLC (base condition) and concentrated to give SC27 (11.00 mg, 20.37 umol,30.68% yield, 97.7% purity) as yellow gum.

336191-17-4, As the paragraph descriping shows that 336191-17-4 is playing an increasingly important role.

Reference£º
Article; Tuyishime, Marina; Lawrence, Rae; Cocklin, Simon; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 228 – 234;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

184637-48-7, tert-Butyl 3-aminopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 6 Intermediate 6.1: 3-tert-Butoxycarbonylamino-1,1-bis-[3-(4-methoxy-phenyl)-propyl]-piperidinium trifluoroacetate Piperidin-3-yl-carbamic acid tert-butyl ester (1 g, 5 mmol) and 1-(3-Bromo-propyl)-4-methoxy-benzene (2.3 ml, 13 mmol), potassium carbonate (1.6 g, 11.6 mmol) and sodium iodide (1.3 g, 8.7 mmol) are dissolved in acetonitril (40 ml) and stirred at reflux for 5 days. The solvent is removed under vacuo and the product purified by preparative HPLC-MS (MeOH/H2O+0.1percent TFA). LC (method F): tR=1.89 min; Mass spectrum (ESI+): m/z=497 [M]+.

184637-48-7, The synthetic route of 184637-48-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WIEDENMAYER, Dieter; HECKEL, Armin; HAMPRECHT, Dieter; US2015/45326; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.137076-22-3,tert-Butyl 4-formylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of tert-butyl 4-formylpiperidine-1-carboxylate (1.00 g, 4.69 mmol) in MeOH (10 mL) was added morpholine (613 mg, 7.04 mmol). The resulting mixture was stirred for 6 hr, then NaBH3CN (444 mg, 7.07 mmol) was added. The resulting solution was stirred at room temperature overnight and quenched with H2O (1 mL). The resulting mixture was concentrated under vacuum. The residue was purified by flash chromatography on silica gel eluting with 3% MeOH in DCM. This resulted in 1.0 g (75%) of tert-butyl 4-(morpholin-4-ylmethyl) piperidine-1-carboxylate as yellow oil. LCMS (Method 25) [M+H]+=285.0, RT=0.59 min., 137076-22-3

The synthetic route of 137076-22-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Genentech, Inc.; Zak, Mark Edward; Ray, Nicholas Charles; Goodacre, Simon Charles; Mendonca, Rohan; Kellar, Terry; Cheng, Yun-Xing; Li, Wei; Yuen, Po-Wai; US2015/336962; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem