Tag: M.W:200-300

73874-95-0, tert-Butyl piperidin-4-ylcarbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

73874-95-0, 10 g (0.050 mol, 1 eq) of 4-boc-amino-piperidine, 6 g (0.060 mol, 1.2 eq) of tetrahydro- 4H-pyran-4-one, 16 g (0.075 mol, 1.5 eq) of sodium triacetoxyborohydride, and 3 g (0.050 mol, 1 eq) of acetic acid were combined in 600 mL of dichloroethane and stirred at ambient temperature. After two days, the reaction was washed with 2 x 200 mL saturated sodium bicarbonate. The organic layer was separated, dried with sodium sulfate, and evaporated to yield 9.2 g (65% yield) of 1 ,1-dimethylethyl [1-(tetrahydro-2H-pyran-4-yl)-4- piperidinyl]carbamate as a white solid. 1H-NMR (400 MHz, DMSO-Of6): delta 6.73 (d, J = 7.6 Hz, 1 H), 3.86 (m, 2H), 3.24 (app t, 2H), 3.16 (m, 1 H), 2.81 (m, 4H), 2.37 (m, 1 H), 2.07 (app t, 2H), 1.73-1.59 (m, 4H), 1.44-1.24 (m, 4H), 1.37 (s, 9H).

The synthetic route of 73874-95-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/36711; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.324769-03-1,(3S,5R)-1-Benzyl-3,5-dimethylpiperidin-4-one,as a common compound, the synthetic route is as follows.

(3R,5S)-1-Benzyl-3,5-dimethyl-piperidin-4-one (from preparation 14) was dissolved in ethanol (200 mL) and di-tert-butyl dicarbonate (5.08 g, 23 mmol) was added, followed by palladium hydroxide on carbon (20% on carbon, 200 mg) and the reaction mixture placed under 40 atmosphere pressure of hydrogen and stirred overnight at room temperature. The reaction mixture was then filtered through a pad of Celite and Arbocel and concentrated in vacuo to afford a yellow oil which crystallised on standing to afford the title compound (5.2 g, 90%) of sufficient purity to use directly in the next stage (preparation 10). 1H NMR (400 MHz, CDCl3) delta 1.03 (6H, d), 1.49 and 1.52 [9H, 2¡Ás (Rotamers)], 2.48-2.76 (4H, m), 4.24-4.53 (2H, m).

324769-03-1, The synthetic route of 324769-03-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc; US2005/176772; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.211108-50-8,tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Sodium hydride in mineral oil (60percent, 0.18 g, 4.6 mmol) was suspended in THF (12 mL) and methyl 2-(dimethoxyphosphoryl)acetate (0.84 g, 4.6 mmol) was added drop wiseat 0 C. The reaction mixture was stirred at 0 00 for 1 h then tert-butyl-3-fluoro-4-oxo- piperidine-1-carboxylate (1.0 g, 4.6 mmol) in THF (5 mL) was added drop wise at 0 C. The reaction mixture was stirred at rtfor 16 h, then quenched with water (10 mL). The reaction mixture was extracted with EtOAc (3 x 20 mL), the organic layers were combined and washed with sat. NaHCO3 sol. (20 mL) and brine (20 mL) then dried(Na2504). The solvents were removed in vacuo and the residue was purified by column chromatography (normal phase, [Biotage SNAP cartridge KP-sil 25 g, 40-63 tim, 60 A, 25 mL per mm, gradient 0percent to 35percent EtOAc in Isohexane]) to give teit-butyl 3-fluoro-4-(2-methoxy-2-oxoethyl idene)pi peridine- 1 -carboxylate (0.94 g, 75percent).1H NMR: (400 MHz, DMSO-d6) oe: 1.39 (d, J = 2.5 Hz, 9 H), 2.20 – 2.35 (m, 1 H), 2.74 -2.96 (m, 2 H), 3.64 (d, J= 2.0 Hz, 3 H), 4.02-4.20 (m, 1 H), 4.22-4.43 (m, 1H), 5.05(ddd, J= 47.5, 4.5, 3.5 Hz, 1 H), 5.98 (5, 1 H), 6.19 (5, 0.5H), 6.31 (5, 0.5H)

211108-50-8, The synthetic route of 211108-50-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; BROWN, Giles Albert; TEHAN, Benjamin Gerald; PICKWORTH, Mark; CANSFIELD, Julie Elaine; (105 pag.)WO2015/140559; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

896464-16-7, tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,896464-16-7

Step 1: To a solution of compound 24a (1 equivalent) in dichloromethane, compound 11a (1.5 eq.) was added sequentially.HOAT (1.5 eq.), HATU (2 eq.), DIPEA (6 eq.), stirred at room temperature for 12 hours.The solvent is then sparged off and directly isolated by column chromatography to afford intermediate 24b.

As the paragraph descriping shows that 896464-16-7 is playing an increasingly important role.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Chinese Academy Of Sciences Shanghai Life Sciences Institute; Zhang Ao; Gao Daming; Ni Jiabin; Hu Hongli; Ding Chunyong; (55 pag.)CN107814792; (2018); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

387827-19-2, tert-Butyl 4-(3-aminophenyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 4 M HCl in dioxane (25 mL) was added to tert-butyl 4-[3-(amino)phenyl]-1-piperidinecarboxylate (2.60 g, 9.00 mmol) in dichloromethane (250 mL). The reaction mixture was stirred at room temperature overnight, concentrated in vacuo, and the residue was dissolved in water (50 mL). The mixture was nuetralized using KOH pellets and extracted with methylene chloride (3¡Á50 mL). The combined organic extracts were dried (MgSO4), concentrated and chromatographed to give the desired product (1.03 g). 1H NMR (400 MHz, CDCl3) delta 7.01 (t, 1H, J=7.6 Hz), 6.62-6.54 (m, 3H), 3.16 (br d, 2H, J=10.3 Hz), 2.75 (dt, 2H, J=2.7, 12.3 Hz), 2.56 (tt, 1H, J=3.6, 12.3 Hz), 1.81 (br d, 2H, J=12.3 Hz), 1.65 (dq, 2H, J=4.0, 12.3 Hz); ESMS m/e: 177.2 (M+H)+.

387827-19-2, 387827-19-2 tert-Butyl 4-(3-aminophenyl)piperidine-1-carboxylate 22049268, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Synaptic Pharmaceutical Corporation; US6727264; (2004); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

85275-45-2, tert-Butyl 3-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The solution of N-Boc-3-hydroxypiperidine (2.1 g, 10 mmol, 1.0 eq) and DIPEA (2.1 mL, 15 mmol, 1.5 eq) in 20 mL DCM was stirred. To the solution was slowly added dropwise methanesulfonyl chloride (1.0 mL, 13 mmol, 1.3 eq) after cooling to 0 C., and mixture was allowed to raise to room temperature. Then the reaction mixture was washed successively with a 1 M HCl solution, saturated aqueous sodium bicarbonate solution, saturated aqueous sodium chloride solution and water. The obtained DCM layer was dried over anhydrous magnesium sulfate, filtered and evaporated to dryness to give the product as a yellow solid (2.65 g, 95.1% yield). MS m/z (ESI): 280.1 [M+H]., 85275-45-2

As the paragraph descriping shows that 85275-45-2 is playing an increasingly important role.

Reference£º
Patent; Si Chuan University; Yang, Shengyong; Wei, Yuquan; (168 pag.)US2017/305920; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

84964-24-9, 1-(3-Bromophenyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

84964-24-9, In the reaction tube by sequentially adding a 1 e (0.5 mmol, 120 mg), 2 a (0.5 mmol, 75 mg), acetonitrile (3 ml), ferric chloride (0.05 mmol, 8.1 mg), di-tert-butyl peroxide (0.5 mmol, 92 mul) and 4 – dimethylamino pyridine (0.05 mmol, 6.1 mg), in oxygen (1 atm) atmosphere at 60 C stirring reaction 24 h. Then, by adding 10 ml saturated salt water quenching reaction, extracted with ethyl acetate (10 ml ¡Á 3), combined with the organic phase, dried with anhydrous sodium sulfate. Filtering, turns on lathe does, too separating by silica gel column (petroleum ether/ethyl acetate=10/1) to obtain white solid product 3 e (101 mg, 55%). The compound of the characterization data are as follows:

As the paragraph descriping shows that 84964-24-9 is playing an increasingly important role.

Reference£º
Patent; Henan Normal University; Fan Xuesen; Shi Xiaonan; Zhang Xinying; He Yan; (18 pag.)CN107501278; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

324769-06-4, 1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Stage (ii): tert-Butyl 4-(4-methoxybenzylamino)-3,3-dimethylpiperidine-1-carboxylate tert-Butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate (3.3 g, 14.53 mmol, 1 eq) and 4-methoxybenzylamine (3.98 g, 29.07 mmol, 2 eq) were dissolved in dichloromethane (40 ml), and stirring was carried out for 2 h at RT. The reaction mixture was cooled to 0 C., and Na(OAc)3BH (9.24 g, 43.61 mmol, 3 eq) was added in portions. Then stirring was carried out for 16 h at RT. The reaction mixture was diluted with dichloromethane (150 ml), washed with water and sat. NaCl solution (in each case 100 ml), dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (Alox neutral, 10% ethyl acetate in hexane) (colourless oil). Yield: 38% (1.948 g, 5.59 mmol).

324769-06-4, 324769-06-4 1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine 22278899, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; GRUENENTHAL GmbH; US2012/71461; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

203662-51-5, 4-Allyl-1-Boc-4-hydroxypiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

9.83 g of tert-butyl 4-allyl-4-hydroxy-1-piperidinecarboxylate was dissolved in 60 ml tetrahydrofuran/water (9:1), a solution (2.5 wt %, 2 ml) of osmium tetraoxide in tert-butyl alcohol and 6.68 g of N-methylmorpholine-N-oxide were added thereto, and the mixture was stirred at room temperature overnight. The reaction solution was evaporated, and the resulting residue was partitioned into ethyl acetate and water, washed with brine and dried over magnesium sulfate. After filtration, the solvent was evaporated, and the resulting residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give 9.11 g of tert-butyl 4-(2,3-dihydroxypropyl)-4-hydroxy-1-piperidinecarboxylate., 203662-51-5

As the paragraph descriping shows that 203662-51-5 is playing an increasingly important role.

Reference£º
Patent; Eisai Co., Ltd.; US6498159; (2002); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1454-53-1, Ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1454-53-1, Preparation of 1-benzyl-4-trifluorornethanesulfonyloxy-1 , 2,5,6- tetrahvdro-rhoyridine-3-carboxylic acid ethyl ester; A solution of 15% sodium carbonate (6L) was prepared and to this was added ethyl N-benzyl-3-oxo-piperidine carbalphaxylate hydrochloride (1800 g, 6.06 mol). The slurry was allowed to stir for one hour at which time most of the solids had dissolved. To this was added MTBE (6L). The organic layer was removed and the aqueous layer was extracted twice more with MTBE (2 L each extraction). The combined organic layers were dried over sodium sulfate, filtered, and the solvent was removed by rotary evaporation giving an orange oil (1422 g, 90%). The oil was used without any further purification, To a room temperature suspension of sodium hydride (120 g, 3.0 mol) in diethyl ether (9 L) was added the free ethyl N-benzyl-3-oxo-piperidine carboxylate (711 g, 2.72 mol) as a solution in diethyl ether (1 L). Once the addition was complete the reaction mixture was allowed to stir at room temperature for one hour. Trifluoromethanesulfonic anhydride (460 mL, 2.72 mol) was then added carefully and the reaction mixture was allowed to stir overnight. The reaction was quenched with saturated ammonium chloride and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate, filtered, and the solvent was removed by rotary evaporation giving 1-benzyl-4-trifluoromethanesulfonyloxy-1 ,2,5,6-tetrahydro- pyridine-3-carboxylic acid ethyl ester as an orange oil (940 g, 88%). The crude product was used without any further purification.

The synthetic route of 1454-53-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER INC.; WO2008/120093; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem