Tag: M.W:200-300

479630-08-5, 1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 47A Tert-butyl 4-[10-nitro-2-oxo-8-(trifluoromethyl)-1,2-dihydropyrimido[1,2-b]indazol-4-yl]piperidine-1-carboxylate Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate (1.00 g, 3.34 mmol, 1.5 eq), 4-nitro-6-(trifluoromethyl)-1H-indazol-3-amine (548 mg, 2.23 mmol, 1 eq) and potassium phosphate (945 mg, 4.45 mmol, 2 eq) were suspended in 1-methoxy-2-propanol (10 mL) in a 20 mL microwave vial. The vial was capped and the mixture was heated in a microwave to 180 C. for 15 min After cooling to RT, the suspension was diluted with 20 mL dichloromethane/methanol (4:1), filtered through a short pad of silica gel with 100 mL dichloromethane/methanol (4:1) and evaporated in vacuo. The residue was purified by preparative HPLC (Method 1A). The combined product fractions were concentrated in vacuo to remove acetonitrile. The resulting suspension was filtered, the residue was washed with water (2 ml) and dried for 16 h at 50 C. in vacuo to give the title compound (90.8 mg, 8% of theory). LC-MS (Method 1B): Rt=1.16 min, MS (ESIPos): m/z=482 [M+H]+

479630-08-5, As the paragraph descriping shows that 479630-08-5 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; Hassfeld, Jorma; KINZEL, Tom; Koebberling, Johannes; CANCHO GRANDE, Yolanda; BEYER, Kristin; Roehrig, Susanne; Koellnberger, Maria; SPERZEL, Michael; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; ELLERMANN, Manuel; US2015/126449; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

140645-23-4, (R)-1-Boc-3-(Aminomethyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(R)-tert-butyl 3-(((3-amino-6-bromopyrazine-2-yl)amino)methyl)piperidine- 1 -carboxylate._10239] (R)-tert-butyl 3-(aminomethyl)piperidine-1 -carboxylate (4.97 g, 22.40 mmol) was dissolved in DMSO (80 ml), and then 3,5-dibromopyrazine-2-amine (8.5 g, 33.60 mmol) and Et3N (6.3 ml) were added, followed by stirring at 130 C. overnight. Afier the completion of the reaction, the reaction mixture was extracted with H20, EA, and brine, followed by drying (Na2SO4), filtration, and concentration under reduced pressure, and the residue was purified by column chromatography (EA:Hex=1:1), to give (R)-tert-butyl 3-(((3-amino-6-bromopyrazine-2-yl)amino)methyl)piperi- dine-i-carboxylate (2.19 g, two steps: 26%).10240] ?H-NMR (300 MHz, CDC13) oe 7.39 (s, 1H), 4.64-4.23 (m, 2H), 3.79-2.92 (m, 5H), 2.25-1.19 (m, 4H), 1.46 (s, 9H)

140645-23-4, 140645-23-4 (R)-1-Boc-3-(Aminomethyl)piperidine 1502023, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.; Jung, Hee Jung; Ha, Jae Du; Cho, Sung Yun; Kim, Hyoung Rae; Lee, Kwang Ho; Lee, Chong Ock; Choi, Sang Un; Park, Chi Hoon; US2015/259350; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

138022-02-3, tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-{[(4-Cyano-benzoyl)-methyl-amino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester To a stirred solution of 4-cyanobenzoic acid (322 mg, 2.19 mmol) in CH2Cl2 (10 mL) was added TBTU (702 mg, 2.19 mmol) and N,N-diisopropylethylamine (1.14 mL, 6.54 mmol) and the reaction mixture stirred at RT for 10 min. 4-Methylaminomethyl-piperidine-1-carboxylic acid tert-butyl ester (500 mg, 2.19 mmol) in DMF (4 mL) was added and the reaction mixture was stirred at RT for 2 h. The crude material was concentrated in vacuo and purified by silica gel column chromatography, eluting with isohexane and increasing the polarity to 100percent EtOAc to afford 4-{[(4-cyano-benzoyl)-methyl-amino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester as a orange solid (700 mg, 89percent). AnalpH2_MeOH-4 min(1): Rt 2.73 min; m/z 358 [M+1]+.

138022-02-3, The synthetic route of 138022-02-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ashworth, Alan; Lord, Christopher James; Elliot, Richard James Rowland; Niculescu-Duvaz, Dan; Porter, Roderick; Boffey, Raymond John; Bayford, Melanie Jayne; Firth-Clark, Stuart; Jarvis, Ashley Nicholas; Perrior, Trevor Robert; Key, Rebekah Elisabeth; US2015/99732; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1454-53-1,Ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

A suspension of ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (5a) (19.5 g, 68.7 mmol) and guanidine carbonate (19.5 g, 41.23 mmol) in ethanol (170 mL) was heated for 16 hours at 120C. The solvent was removed under reduced pressure, reconstituted in acetonitrile where the crude precipitated and was isolated by filtration. The solid was used as such in the next step without further purification. 1H NMR (300 MHz, DMSO-d6) d ppm 2.35 – 2.46 (m, 2 H), 2.57 – 2.65 (m, 2 H), 3.04 (s, 2 H), 3.60 (s, 2 H), 6.28 (br. s., 2 H), 7.27 (dt, J=8.7, 4.5 Hz, 1 H), 7.31 – 7.36 (m, 4 H), 10.74 (br. s., 1 H). MS m/z: 257 [M+H]+.

1454-53-1, The synthetic route of 1454-53-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; McGowan, David C.; Herschke, Florence; Khamlichi, Mourad D.; Rosauro, Mari Luz; Benedicto, Sara M. Perez; Pauwels, Frederik; Stoops, Bart; Pande, Vineet; Scholliers, Annick; Van Schoubroeck, Bertrand; Mostmans, Wendy; Van Dijck, Kris; Thone, Tine; Horton, Helen; Fanning, Gregory; Jonckers, Tim H.M.; Raboisson, Pierre; Bioorganic and Medicinal Chemistry Letters; vol. 28; 19; (2018); p. 3216 – 3221;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71233-25-5,1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate,as a common compound, the synthetic route is as follows.,71233-25-5

Intermediate 1, Step a: tert-Butyl 4-hydroxy-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate To a solution of 1-tert-butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate (2.00 g, 7.39 mmol) in EtOH (37 mL) was added formamidine hydrochloride (910 mg, 11.08 mmol) followed by NaOEt (6.89 mL, 2.68 M in EtOH) dropwise. The mixture was then heated to reflux overnight. The mixture was concentrated in vacuo and then dissolved in a minimum amount of water. The pH was adjusted to pH 7 with 1 N HCl. The aqueous layer was then saturated with solid NaCl and extracted with a combination of EtOAc and DCM. The combined organic extracts were dried over Na2SO4, filtered and concentrated in vacuo. Chromatography on SiO2 eluting with IPA/EtOAc afforded the desired product as a white solid (993 mg, 53percent). MS (ESI) mass calcd. C12H12N3O3, 251.13. m/z found 252.1 [M+H]+. 1H NMR (500 MHz, CDCl3): 8.05 (s, 1H), 4.42 (s, 2H), 3.69-3.61 (m, 2H), 2.63 (s, 2H), 1.49 (s, 9H).

As the paragraph descriping shows that 71233-25-5 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; Alcazar Vaca, Manuel Jesus; Andres Gil, Jose Ignacio; Letavic, Michael A.; Rudolph, Dale A.; Shireman, Brock T.; Stenne, Brice M.; Ziff, Jeannie M.; US2014/275120; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.135632-53-0,tert-Butyl (piperidin-4-ylmethyl)carbamate,as a common compound, the synthetic route is as follows.

General procedure: NaBH(OAc)3 (typically 1.4 eq) was added to a solution of amine 5 (typically 1.0 eq) and aldehyde (typically 1.0 eq) in 1,2-dichloroethane (DCE). The mixture was stirred at rt until the conversion was finished as judged by TLC and LC/MS analyses. The reaction mixture was quenched with 10% K2CO3 aqueous solution. The product was extracted with dichloromethane (DCM) (3x). The combined organic layers were washed with brine (1x). Subsequently, the organic layer was dried with anhydrous Na2SO4. The solvent was removed in vacuo to give crude product which was purified by flash column chromatography. Unless mentioned otherwise, cyclohexane/5% TEA: EtOAc/5%TEA and a gradient flow from 100-0% to 50-50% were used.

135632-53-0, The synthetic route of 135632-53-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Adlere; Sun; Zarca; Roumen; Gozelle; Viciano Perpina; Caspar; Arimont; Bebelman; Briddon; Hoffmann; Hill; Smit; Vischer; Wijtmans; de Graaf; de Esch; Leurs; European Journal of Medicinal Chemistry; vol. 162; (2019); p. 631 – 649;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141699-59-4,tert-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a stirred solution of 4-bromo-pyrazole (10.44 g, 71.03 mmol) in anhydrous DMF (96 mL), cooled to 0¡ã C., was slowly added NaH (60percent in mineral oil) (3.13 g, 78.133 mmol). The solution was stirred for 1 hour at 0¡ã C. 4-Methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester (19.82 g, 71.03 mmol) was added slowly and the reaction was heated to 100¡ã C. overnight or until consumption of the pyrazole by NMR. The reaction was cooled to room temperature and water added (20 mL) followed by extraction with EtOAc. The combined extracts were washed with saturated aqueous NaCl (4*20 mL), dried with Na2SO4 and concentrated to afford 4-(4-bromo-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester as an orange oil. The oil was purified using silica gel chromatography eluding with 10percent EtOAc/hexanes to 25percent EtOAc/hexanes to provide 4-(4-bromo-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester as a white solid (10.55 g, 45percent yield) with a Rf=0.4 (25percent EtOAc/hexanes, using iodine as the stain). 1H NMR (CDCl3, 400 MHz) delta 7.46 (s, 1H), 7.43 (s, 1H), 4.23 (m, 3H), 2.88 (m, 2H), 2.10 (m, 2H), 1.88 (m, 2H), 1.47 (s, 9H)., 141699-59-4

141699-59-4 tert-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate 4184869, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; AGOURON PHARMACEUTICALS, INC.; US2006/46991; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

373604-28-5, tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Sodium hydride (40 mg, 1.0 mmol) was added to a 0C solution of tert-butyl 3-fluoro-4- hydroxypiperidine-1-carboxylate (200 mg, 0.9 12 mmol) in DMF (3.0 mL). The reaction mixture was stirred at 0C for 5 minutes, and then iodomethane (63 jiL, 1.0 mmol) was added. The mixture was slowly warmed to room temperature and stirred for 16 h. The mixture was dilutedwith EtOAc and washed with water and then brine. The organic layer was dried over sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by colunm chromatography on silica gel (0 – 70% EtOAc/Hexanes) to afford tert-butyl 3-fluoro-4- methoxypiperidine-1-carboxylate as an oil.

373604-28-5, As the paragraph descriping shows that 373604-28-5 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; FISCHER, Christian; BOGEN, Stephane, L.; CHILDERS, Matthew, L.; LLINAS, Francesc Xavier Fradera; ELLIS, J. Michael; ESPOSITE, Sara; HONG, Qingmei; HUANG, Chunhui; KIM, Alexander, J.; LAMPE, John, W.; MACHACEK, Michelle, R.; MCMASTERS, Daniel, R.; OTTE, Ryan, D.; PARKER, Dann, L., Jr.; REUTERSHAN, Michael; SCIAMMETTA, Nunzio; SHAO, Pengcheng, P.; SLOMAN, David, L.; UJJAINWALLA, Feroze; WHITE, Catherine; WU, Zhicai; YU, Yang; ZHAO, Kake; GIBEAU, Craig; BIFTU, Tesfaye; BIJU, Purakkattle; CHEN, Lei; CLOSE, Joshua; FULLER, Peter, H.; HUANG, Xianhai; PARK, Min, K.; SIMOV, Vladimir; WITTER, David, J.; ZHANG, Hongjun; (297 pag.)WO2016/89797; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.138227-63-1,tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Reference Example 6 N-[4-(1-t-Butoxycarbonylpiperidin-4-yloxy)phenyl]ethanesulfonamide To a solution of 4-(1-t-butoxycarbonylpiperidin-4-yloxy)aniline (10.6 g) and pyridine (8 ml) in dichloromethane (75 ml) was added dropwise ethanesulfonyl chloride (4.1 ml) in an ice bath and the mixture was stirred at room temperature for 5 hours. After addition of methanol (1 ml), the reaction mixture was concentrated in vacuo. The residue was purified by chromatography on a silica gel column using hexane/ethyl acetate=3/2 as an eluant to give the desired compound (11.7 g, yield 84%) as a pale pink solid. 1H NMR (400 MHz, CDCl3) delta ppm: 1.38 (3H, t, J=8.0), 1.47 (9H, s), 1.74 (2H, m), 1.90 (2H, m), 3.07 (2H, q, J=8.0), 3.34 (2H, m), 3.69 (2H, m), 4.42 (1H, m), 6.88 (2H, d, J=9.0), 7.17 (2H, d, J=9.0)., 138227-63-1

138227-63-1 tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate 22181157, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Sankyo Company, Limited; US6555556; (2003); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1205-72-7, 1-Benzylpiperidin-4-amine dihydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of (i?)-tetrahydro-2-furoic acid (58.5 g, 504 mmol) and oxalyl chloride(86 mL, 1.0 mol) in 100 mL CH2CI2 were refluxed for 2 hours in a flask equipped with a CaCl2 guard tube. After the solution was cooled to room temperature the solvents and excess oxalyl chloride were removed by evaporation under reduced pressure. The resulting acid chloride was dissolved in 200 mL CH2CI2 and added dropwise to a solution of 1 -benzyl-4-amino piperidine dihydrochloride (142 g, 539 mmol) and triethylamine (240 mL, 1.7 mol) in 300 mL CH2C12 cooled in an ice bath. The resulting mixture was stirred for 2 hours at room temperature and subsequently washed twice with 300 mL portions of 5% aq. NaHC03 and 300 mL saturated aq. NaCl solution, dried over Na2S04, filtered, and evaporated to dryness under reduced pressure. The solid residue was triturated with 500 mL heptanes, collected by filtration, and washed twice with 200 mL portions of heptanes. The solid was air-dried at 45 C to yield (i?)-tetrahydrofuran-2-carboxylic acid (l-benzyl-piperidin-4-yl)-amide (128 g, 88%) as an off-white solid. ^-NMR (300 MHz, CDCI3): 8 7.35-7.20 (m, 5H), 6.58 (bs, 1H), 4.29 (dd, J= 5.9, 8.4 Hz, 1H), 3.92-3.77 (m, 2H), 3.48 (s, 2H), 2.82-2.74 (m, 2H), 2.32-2.21 (m, 1H), 2.19-1.95 (m, 3H), 1.94-1.78 (m, 4H), 1.58-1.40 (m, 2H) ppm., 1205-72-7

As the paragraph descriping shows that 1205-72-7 is playing an increasingly important role.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2006/28904; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem